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Geriatrics / Original Article
A link between systemic low-grade inflammation and frailty in older adults: clinical evidence from a nationwide population-based study
Min-gu Kang, Hee-Won Jung, Beom-Jun Kim
Korean J Intern Med. 2024;39(6):1011-1020. Published online July 23, 2024
Background/Aims: Despite the possible role of systemic low-grade inflammation on frailty, the majority of previous studies have focused solely on the phenotypic frailty with limited participant numbers, thereby weakening the evidence supporting the notion that circulating C-reactive protein (CRP) co..
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Geriatrics / Original Article
Effects of aging on accompanying intermittent hypoxia in a bleomycin-induced pulmonary fibrosis mouse model
Heayon Lee, In Kyoung Kim, Jeonghyeon Im, Bae Suk Jin, Hwan Hee Kim, Sei Won Kim, Chang Dong Yeo, Sang Haak Lee
Korean J Intern Med. 2023;38(6):934-944. Published online October 5, 2023
Background/Aims: Obstructive sleep apnea (OSA) is prevalent in older patients with idiopathic pulmonary fibrosis (IPF); however, it is underrecognized. OSA is characterized by intermittent hypoxia (IH) and sleep fragmentation. In this study, we evaluated the effects of IH in an older mouse model of..
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Review
Role of T cells in ischemic acute kidney injury and repair
Kyungho Lee, Hye Ryoun Jang
Korean J Intern Med. 2022;37(3):534-550. Published online April 28, 2022
Ischemic acute kidney injury (AKI) is a common medical problem with significant mortality and morbidity, affecting a large number of patients globally. Ischemic AKI is associated with intrarenal inflammation as well as systemic inflammation; thus, the innate and adaptive immune systems are implicate..
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Review
The role of inflammation in diabetic kidney disease
Su Woong Jung, Ju-Young Moon
Korean J Intern Med. 2021;36(4):753-766. Published online July 1, 2021
Diabetic kidney disease (DKD) has been the leading cause of chronic kidney disease for over 20 years. Yet, over these two decades, the clinical approach to this condition has not much improved beyond the administration of glucose-lowering agents, renin-angiotensin-aldosterone system blockers for blo..
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Gastroenterology / Original Article
17β-Estradiol reduces inflammation and modulates antioxidant enzymes in colonic epithelial cells
Hee Jin Son, Nayoung Kim, Chin-Hee Song, Sun Min Lee, Ha-Na Lee, Young-Joon Surh
Korean J Intern Med. 2020;35(2):310-319. Published online October 22, 2018
Background/Aims: Estrogen is known to have protective effect in colorectal cancer development. The aims of this study are to investigate whether estradiol treatment reduces inflammation in CCD841CoN, a female human colonic epithelial cell line and to uncover underlying mechanisms of estradiol effects.
M..
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Rheumatology / Original Article
Clinical features and recurrent attack in gout patients according to serum urate levels during an acute attack
Jung Sun Lee, Oh Chan Kwon, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong
Korean J Intern Med. 2020;35(1):240-248. Published online January 28, 2019
Background/Aims: A substantial portion of gout patients have normal serum urate levels during an acute attack but data on the clinical characteristics and risk of recurrence compared with hyperuricemic patients are limited. Methods: In this retrospective cohort study, clinical features of normourice..
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Hemato-oncology / Original Article
Inflammatory markers as prognostic indicators in pancreatic cancer patients who underwent gemcitabine-based palliative chemotherapy
Hong Jun Kim, Suk-young Lee, Dae Sik Kim, Eun Joo Kang, Jung Sun Kim, Yoon Ji Choi, Sang Cheul Oh, Jae Hong Seo, Jun Suk Kim
Korean J Intern Med. 2020;35(1):171-184. Published online October 26, 2018
Background/Aims: Patients with pancreatic cancer (PC) generally have poor clinical outcomes. Early determination of their prognosis is crucial for developing a therapeutic strategy. Recently, various inflammatory markers have been validated as prognostic indicators for many cancers, including PC. Ho..
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Pulmonology / Original Article
Left ventricular dysfunction in relation with systemic inflammation in chronic obstructive pulmonary disease patients
Sule Tas Gulen, Ufuk Eryilmaz, Mustafa Yilmaz, Fisun Karadag
Korean J Intern Med. 2019;34(3):569-578. Published online October 29, 2018
Background/Aims: Most important cause of mortality in chronic obstructive pulmonary disease (COPD) patients is known to be cardiovascular disease (CVD). The objective of the present study was to evaluate the echocardiographic parameters in COPD patients with or without pre-diagnosed CVD and to inves..
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Pulmonology / Original Article
Association between blood pressure, inflammation and spirometry parameters in chronic obstructive pulmonary disease
Sulhattin Arslan, Gürsel Yildiz, Levent Özdemir, Erdal Kaysoydu, Bülent Özdemir
Korean J Intern Med. 2019;34(1):108-115. Published online November 16, 2018
Background/Aims: Many systems including the cardiovascular system (ischemic heart diseases, heart failure, and hypertension) may act as comorbidities that can be seen during the course of chronic obstructive pulmonary disease (COPD). Comorbidities affect the severity and prognosis of COPD negatively..
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Allergy / Original Article
Effect of the anti-IL-17 antibody on allergic inflammation in an obesity-related asthma model
Lin Liang, Jung Hur, Ji Young Kang, Chin Kook Rhee, Young Kyoon Kim, Sook Young Lee
Korean J Intern Med. 2018;33(6):1210-1223. Published online April 19, 2018
Background/Aims: The co-occurrence of obesity aggravates asthma symptoms. Diet-induced obesity increases helper T cell (TH) 17 cell differentiation in adipose tissue and the spleen. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pravastatin can potentially be used to treat asthma in o..
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Hemato-oncology / Original Article
Chronic kidney disease in the BCR-ABL1-negative myeloproliferative neoplasm: a single-center retrospective study
Seung-Woo Baek, Ji Young Moon, Hyewon Ryu, Yoon-Seok Choi, Ik-Chan Song, Hyo-Jin Lee, Hwan-Jung Yun, Samyoung Kim, Deog-Yeon Jo
Korean J Intern Med. 2018;33(4):790-797. Published online March 17, 2017
Background/Aims: Renal complications related to BCR-ABL1-negative myeloproliferative neoplasms (MPNs) have not been examined fully in Asian populations.
Methods: We analyzed estimated glomerular filtration rate (eGFR) and its changes with time retrospectively in patients with BCR-ABL1..
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Nephrology / Original Article
Long-term prognosis of end-stage renal disease patients with normal myocardial perfusion as determined by single photon emission computed tomography
Gun Ha Park, Jae Won Song, Chang Min Lee, Young Rim Song, Sung Gyun Kim, Hyung Jik Kim, Jwa Kyung Kim
Korean J Intern Med. 2018;33(1):148-156. Published online November 22, 2016
Background/Aims: Normal myocardial perfusion is closely associated with very low rates of cardiac events and better long-term outcomes; however, little is known about its prognostic value in patients with end-stage renal disease (ESRD).
Methods: A total of 286 incident patients underwent baseline c..
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Endocrinology-metabolism / Review
Metabolically healthy obesity: a friend or foe?
Chang Hee Jung, Woo Je Lee, Kee-Ho Song
Korean J Intern Med. 2017;32(4):611-621. Published online June 5, 2017
Obesity is associated with a reduced life expectancy, largely because obese individuals are at an increased risk of type 2 diabetes, cardiovascular disease, and several types of cancer. Much interest has recently focused on the concept of “all obesity is not created equally.” Obese individuals wi..
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Rheumatology / Review
Macrophage migration inhibitory factor: a potential therapeutic target for rheumatoid arthritis
Kyoung-Woon Kim, Hae-Rim Kim
Korean J Intern Med. 2016;31(4):634-642. Published online May 12, 2016
Macrophage migration inhibitory factor (MIF) is originally identified in the culture medium of activated T lymphocytes as a soluble factor that inhibits the random migration of macrophages. MIF is now recognized as a multipotent cytokine involved in the regulation of immune and inf lammatory respons..
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Rheumatology / Original Article
The role of neutrophil lymphocyte ratio to leverage the differential diagnosis of familial Mediterranean fever attack and acute appendicitis
Adem Kucuk, Mehmet Fatih Erol, Soner Senel, Emir Eroler, Havvanur Alparslan Yumun, Ali Ugur Uslu, Asiye Mukaddes Erol, Deniz Tihan, Ugur Duman, Tevfik Kucukkartallar, Yalcin Solak
Korean J Intern Med. 2016;31(2):386-391. Published online February 11, 2016
Background/Aims: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by attacks of fever and diffuse abdominal pain. The primary concern with this presentation is to distinguish it from acute appendicitis promptly. Thus, we aimed to evaluate the role of neutrophil lym..
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Cardiology / Review
Breakthrough in heart failure with preserved ejection fraction: are we there yet?
Shir Lynn Lim, Carolyn Su Ping Lam
Korean J Intern Med. 2016;31(1):1-14. Published online December 28, 2015
Heart failure with preserved ejection fraction (HFPEF) is a global health problem of considerable socioeconomic burden. It is projected to worsen with the aging population worldwide. The lack of effective therapies underscores our incomplete understanding of this complex heterogeneous syndrome. A no..
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Hemato-oncology / Original Article
The prognostic impact of inflammatory factors in patients with multiple myeloma treated with thalidomide in Korea
Cheolsu Kim, Ho Sup Lee, Chang-Ki Min, Je Jung Lee, Kihyun Kim, Dok Hyun Yoon, Hyeon Seok Eom, Hyewon Lee, Won Sik Lee, Ho-Jin Shin, Ji Hyun Lee, Yong Park, Jae-Cheol Jo, Young Rok Do, Yeung-Chul Mun
Korean J Intern Med. 2015;30(5):675-683. Published online August 27, 2015
Background/Aims: The purpose of this study was to determine the correlations between inflammatory factors—including absolute lymphocyte count, lactate dehydrogenase, β2-microglobulin, albumin, C-reactive protein, and ferritin—and the prognosis for survival in patients with multiple myeloma (MM) ..
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Rheumatology / Original Article
Predictive factors of radiographic progression in ankylosing spondylitis
Hyungjin Kim, Jaejoon Lee, Joong Kyong Ahn, Jiwon Hwang, Eun-Jung Park, Hyemin Jeong, Hoon-Suk Cha, Eun-Mi Koh
Korean J Intern Med. 2015;30(3):391-397. Published online April 29, 2015
Background/Aims: The course of ankylosing spondylitis (AS) is rather variable, and the factors that predict radiographic progression remain largely obscure. In this study, we tried to determine the clinical factors and laboratory measures that are useful in predicting the radiographic progression of..
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Cardiology / Original Article
Interleukin-33, matrix metalloproteinase-9, and tissue ınhibitor of matrix metalloproteinase-1 in myocardial infarction
Savas Guzel, Ozden Serin, Eda Celik Guzel, Banu Buyuk, Güzin Yılmaz, Guvenc Güvenen
Korean J Intern Med. 2013;28(2):165-173. Published online February 27, 2013
Background/AimsAcute coronary syndrome (ACS) is characterized by increased inflammatory processes and endothelial activation. We investigated the association between ACS and inflammatory mediators and matrix-degrading enzymes. MethodsWe prospect..
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Original Article
Interleukin-6 -634 C/G and -174 G/C Polymorphisms in Korean Patients Undergoing Hemodialysis
Jung-Hwa Ryu, Seung-Jung Kim
Korean J Intern Med. 2012;27(3):327-337. Published online September 1, 2012
Background/AimsChronic inflammatory status is a possible risk factor for vascular access dysfunction in hemodialysis (HD) patients, but susceptibility differences appear among individuals. Interleukin (IL)-6 is a well-known inflammatory cytokine with various polymorphisms. We ..
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