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Endocrinology-metabolism / Original Article
Diabetes progression and severe hypoglycemia: a nationwide cohort study of 2,475,605 adults with type 2 diabetes mellitus
Kyu-Na Lee, Bongseong Kim, Mee Kyoung Kim, Sukil Kim
Korean J Intern Med. 2026;41(5):916-926. Published online September 1, 2026
Background/Aims: Severe hypoglycemia (SH) is a major concern in type 2 diabetes mellitus (T2DM). We evaluated whether a composite diabetes progression score could predict incident SH.
Methods: Using the Korean National Health Insurance Service database, we identified 2,475,605 adults with T2DM who und..
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Review
Severe hypoglycemia as a preventable risk factor for cardiovascular disease in patients with type 2 diabetes mellitus
Soo-Yeon Choi, Seung-Hyun Ko
Korean J Intern Med. 2021;36(2):263-270. Published online January 8, 2021
Glucose-lowering medication and lifestyle modification are essential for optimal glycemic control in patients with type 2 diabetes mellitus (T2DM). However, glucose-lowering agents, particularly insulin and insulin secretagogues, may cause hypoglycemia, which has multiple negative effects on the car..
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Endocrinology-metabolism / Review
Is islet transplantation a realistic approach to curing diabetes?
Sang-Man Jin, Kwang-Won Kim
Korean J Intern Med. 2017;32(1):62-66. Published online January 1, 2017
Since the report of type 1 diabetes reversal in seven consecutive patients by the Edmonton protocol in 2000, pancreatic islet transplantation has been reappraised based on accumulated clinical evidence. Although initially expected to therapeutically target long-term insulin independence, islet trans..
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Endocrinology-metabolism / Original Article
Blood electrolyte disturbances during severe hypoglycemia in Korean patients with type 2 diabetes
Mi Yeon Kang
Korean J Intern Med. 2015;30(5):648-656. Published online August 27, 2015
Background/Aims: To investigate abnormalities in blood electrolyte levels during severe hypoglycemia in Korean patients with type 2 diabetes mellitus (T2DM) in a clinical setting.
Methods: Blood electrolyte levels in adult T2DM patients during severe hypoglycemia were collected from January 1, 200..
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Endocrinology-metabolism / Review
Avoiding or coping with severe hypoglycemia in patients with type 2 diabetes
Jae-Seung Yun, Seung-Hyun Ko
Korean J Intern Med. 2015;30(1):6-16. Published online December 30, 2014
Hypoglycemia is a major barrier to achieving the glycemic goal in patients with type 2 diabetes. In particular, severe hypoglycemia, which is defined as an event that requires the assistance of another person to actively administer carbohydrates, glucagon, or take other corrective actions, is a seri..
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Case Report
Type B insulin-resistance syndrome presenting as autoimmune hypoglycemia, associated with systemic lupus erythematosus and interstitial lung disease
Seon Mee Kang, Heung Yong Jin, Kyung Ae Lee, Ji Hyun Park, Hong Sun Baek, Tae Sun Park
Korean J Intern Med. 2013;28(1):98-102. Published online December 28, 2012
We describe an unusual case of systemic lupus erythematosus with pulmonary manifestations presenting as hypoglycemia due to anti-insulin receptor antibodies. A 38-year-old female suffered an episode of unconsciousness and was admitted to hospital where her blood glucose was found to be 18 mg/dL. ..
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