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Gastroenterology
Increasing correlation between oral and gastric microbiota during gastric carcinogenesis
Hee Sang You, Jae Yong Park, Hochan Seo, Beom Jin Kim, Jae Gyu Kim
Korean J Intern Med. 2024;39(4):590-602. Published online June 24, 2024
Background/Aims: Recent research has increasingly focused on the role of the gastric microbiome in the development of gastric cancer. We aimed to investigate the changes in the microbiome during gastric carcinogenesis in structural and functional aspects, with a specific focus on the association bet..
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Clinical risk factors and pattern of initial fungal contamination in endoscopic biopsy-derived gastrointestinal cancer organoid culture
Su Youn Nam, Seung Jin Lee, Hee Jung Lim, Ji Young Park, Seong Woo Jeon
Korean J Intern Med. 2021;36(4):878-887. Published online April 8, 2021
Background/Aims: Because gastrointestinal tract is not sterile, primary culture has contamination risk despite of massive washing with antimicrobial media. Microbial contamination can play a key role in initial failure during biopsy-derived primary tumor culture.
Methods: Tumor tissue was acquired ..
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Hemato-oncology
Association between absolute lymphocyte count and overall mortality in patients with surgically resected gastric cancer
Se Jun Park, Jinsoo Lee, Hyunho Kim, Kabsoo Shin, MyungAh Lee, Jae Myung Park, Myung-Gyu Choi, Cho Hyun Park, Kyo Young Song, Han Hong Lee, In-Ho Kim
Korean J Intern Med. 2021;36(3):679-688. Published online February 19, 2021
Background/Aims: Lymphocytes are an important component of the cell-mediated immune system. As lymphopenia is reportedly associated with poor prognoses in patients with various cancers, we investigated this notion in patients who underwent curative gastrectomy.
Methods: We retrospectively analyzed ..
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Gastroenterology
Current status of endoscopic submucosal dissection for early gastric cancer in Korea: role and benefits
Sang Gyun Kim, Da Hyun Lyu, Chan Mi Park, Na Rae Lee, Jiyoung Kim, Youngju Cha, Hwoon-Yong Jung
Korean J Intern Med. 2019;34(4):785-793. Published online June 21, 2018
Background/Aims: This study was aimed to investigate the current clinical status of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in Korea based on a National Health Insurance (NHI) database between 2011 and 2014.
Methods: The claims data of ESD for EGC in Korean NHI were re..
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Hemato-oncology
Third-line docetaxel chemotherapy for recurrent and metastatic gastric cancer
Ji Hyun Lee, Sung-Hyun Kim, Sung Yong Oh, Suee Lee, Hojin Lee, Hye Jung Lee, Hyo-Jin Kim
Korean J Intern Med. 2013;28(3):314-321. Published online May 1, 2013
Background/AimsTo determine the efficacy and toxicity of docetaxel as a third-line therapy for patients with relapsed gastric cancer who have undergone modified oxaliplatin-fluorouracil (m-FOLFOX)-4 and modified irinotecan-fluorouracil (m-FOLFIRI) regimens.
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S-1 Monotherapy as a Neoadjuvant Treatment for Locally Advanced Gastric Cancer
Jong Yul Jung, Sun Young Rha, Joong Bae Ahn, Woo Ick Yang, Sung Hoon Noh, Hyun Cheol Chung, Hei-Cheul Jeung
Korean J Intern Med. 2008;23(1):37-41. Published online March 20, 2008
S-1, a novel oral fluoropyrimidine, is an effective therapeutic agent for gastric cancer. Herein, we report a case with locally advanced gastric cancer that achieved a curative resection after S-1 monotherapy as neoadjuvant treatment. A 68-year-old man was diagnosed with gastric cancer and massiv..
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Adrenalectomy for Metastatic Disease to the Adrenal Gland from Gastric Cancer: Report of a Case
Young Rok Do, Hong Suk Song, In Ho Kim
Korean J Intern Med. 2007;22(1):18-20. Published online March 31, 2007
Metastases to the adrenal glands are frequently found at autopsy. In practice, adrenal metastases have generally been accepted as evidence of blood-borne systemic disease. So, clinically curable adrenal metastases is a rare malady. The role for surgical resection in adrenal metastases has not bee..
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Capecitabine and Oxaliplatin (XELOX) for the Treatment of Patients with Metastatic Gastric Cancer and Severe Liver Dysfunction
Seung Jae Hwang, Jong Won Park, Sehe Dong Lee, Gyong Jung Kim, Cheol Ho Sin, Seung-Hyun Nam, Bong-Seog Kim
Korean J Intern Med. 2006;21(4):252-255. Published online December 31, 2006
Gastric cancer patients with severe liver dysfunction secondary to hepatic metastases have limited treatment options. Most cytotoxic drugs have a narrow therapeutic index. Although both capecitabine and oxaliplatin have been well tolerated as single agents for patients with severe hepatic dysfunc..
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p53 Genetic Polymorphism of Gastric cancer in Korea
Woo Chul Chung, Kang Moon Lee, Bo In Lee, Ji Sung Chun, So Yeon Lee, U-Im Chang, Soo Heon Park, Jin Mo Yang, Kyu Yong Choi, In-Sik Chung
Korean J Intern Med. 2006;21(1):28-32. Published online March 30, 2006
Background/AimsDeletion or functional loss of the p53 tumor suppression gene plays a role in oncogenic transformation. The codon 72 polymorphism on exon 4 in the p53 gene produces variant proteins with either arginine (Arg) or proline (Pro), a..
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Clinicopathologic Significance of Gastric and Intestinal Phenotypic Marker Expression in Gastric Carcinomas
Gwang Ha Kim, Geun Am Song, Do Youn Park, Dong Hyun Lee, Tae Oh Kim, Seong Hun Lee, Jeong Heo, Dae Hwan Kang, Mong Cho
Korean J Intern Med. 2005;20(3):191-197. Published online September 30, 2005
BackgroundIt is well known that both gastric and intestinal phenotypic cell markers are expressed in gastric cancers. This study was aimed at investigating the correlation between gastric and intestinal phenotypic marker expression patterns of tumors and the clinicopathologic ..
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High Frequency of Microsatellite Instability in Intestinal-type Gastric Cancer in Korean Patients
Won Hyuk Choe, Sun-Young Lee, Jun Haeng Lee, Sang Goon Shim, Young-Ho Kim, Poong-Lyul Rhee, Jong Chul Rhee, Chang-Seok Ki, Jong-Won Kim, Sang Yong Song, Jae J. Kim
Korean J Intern Med. 2005;20(2):116-122. Published online June 30, 2005
BackgroundAlthough there have been some reports on microsatellite alterations in gastric cancer, findings are inconsistent regarding the associations between histological classification and microsatellite instability (MSI). In the present study, we attempted to determine wheth..
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Prognostic Significance of Immunohistochemical Expression of p53 and Retinoblastoma Gene Protein (pRB) in Curatively Resected Gastric Cancer
Hong Suk Song, In Ho Kim, Soo Sang Sohn, Kun Young Kwon, Won Sik Lee
Korean J Intern Med. 2005;20(1):1-7. Published online March 31, 2005
BackgroundThe aim of this study was to determine the prognostic significance of the expression of p53 and retinoblastoma (Rb) gene products in cases of curatively resected gastric adenocarcinoma, by immunohistochemical analysis. Methods</t.. </div>
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