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A Case of Severe Coronary Spasm Associated with 5-Fluorouracil Chemotherapy
Sang-Min Kim, Cheol-Hoon Kwak, Bora Lee, Seong Beom Kim, Jung-Ju Sir, Wook-Hyun Cho, Suk-Koo Choi
Korean J Intern Med. 2012;27(3):342-345. Published online September 1, 2012
Cardiotoxicity associated with 5-fluorouracil (FU) is an uncommon, but potentially lethal, condition. The case of an 83-year-old man with colon cancer who developed chest pain during 5-FU infusion is presented. The electrocardiogram (ECG) showed pronounced ST elevation in the lateral leads, and t..
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A Case of Therapy-Related Acute Myeloid Leukemia Following 5-Fluorouracil Chemotherapy
Hye Jeong Park, Jung-Hye Choi, Kyeong A Lee, Hyun Cheol Kim, Young-Soo Nam, Young-Ha Oh, Woong-Soo Lee
Korean J Intern Med. 2012;27(1):115-117. Published online February 28, 2012
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Efficacy and Safety of Hepatic Arterial Infusion of Fluorouracil with Leucovorin as Salvage Treatment for Refractory Liver Metastases from Colorectal Cancer
Hyun Jung Lee, Yoon Soo Lee, Keun-Wook Lee, So Yeon Kim, Chang Jin Yoon, Dong-Yeop Shin, Yun Gyoo Lee, Se Yeon Choi, Sung-Gwon Kang, Sung-Bum Kang, Jee Hyun Kim
Korean J Intern Med. 2011;26(1):82-88. Published online March 2, 2011
Background/AimsLimited options remain for patients with metastatic colorectal cancer (CRC) after failure of standard systemic chemotherapy. Readministration of chemotherapeutic agents by hepatic arterial infusion (HAI) has the rationale of providing higher concentrations of ch..
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Unpredicted Severe Toxicity after 5-Fluorouracil Treatment due to Dihydropyrimidine Dehydrogenase Deficiency
Jin Ho Baek, Jong Gwang Kim, Shi Nae Kim, Dong Hwan Kim, Sang Kyun Sohn, Young Jun Hong, Kyu Bo Lee
Korean J Intern Med. 2006;21(1):43-45. Published online March 30, 2006
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). Thus, patients with a DPD deficiency are at risk of developing severe 5-FU-associated toxicity. A 37-year-old female with gastric cancer underwent a curative operation, ..
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