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Nephrology
The optimal anti-phospholipase A2 receptor cutoff for the diagnosis of idiopathic membranous nephropathy: a single-center retrospective study
Chaofan Li, Ping Li, Wenkai Guo, Lei Chen, Jiatong Li, Rong Wang, Bing Chen
Korean J Intern Med. 2022;37(1):154-166. Published online July 22, 2021
Background/Aims: Anti-phospholipase A2 receptor (PLA2R) autoantibody is the main biomarker of idiopathic membranous nephropathy (IMN). We aimed to find a new cutoff value of anti-PLA2R for patients with IMN and to explore the relevance between this antibody and baseline clinical parameters.
Methods..
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Infectious diseases
Can reactogenicity predict immunogenicity after COVID-19 vaccination?
Young Hoon Hwang, Kyoung-Ho Song, Yunsang Choi, Suryeong Go, Su-Jin Choi, Jongtak Jung, Chang Kyung Kang, Pyoeng Gyun Choe, Nam-Joong Kim, Wan Beom Park, Myoung-don Oh
Korean J Intern Med. 2021;36(6):1486-1491. Published online May 28, 2021
Background/Aims: This study aimed to assess the association between local and systemic reactogenicity and humoral immunogenicity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.
Methods: Adverse events were prospectively evaluated using an electronic diary in 135 heal..
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Gastroenterology
Immunological measurement of aspartate/alanine aminotransferase in predicting liver fibrosis and inflammation
Hyun Jeong Kim, Sang Yeol Kim, Suk Pyo Shin, Young Joo Yang, Chang Seok Bang, Gwang Ho Baik, Dong Joon Kim, Young Lim Ham, Eui Yul Choi, Ki Tae Suk
Korean J Intern Med. 2020;35(2):320-330. Published online January 23, 2019
Background/Aims: Enzymatic analysis of aspartate/alanine aminotransferase (AST/ALT) does not exactly represent the progression of liver fibrosis or inflammation. Immunoassay for AST (cytoplasmic [c] AST/mitochondrial [m] AST) and ALT (ALT1/ALT2) has been suggested as one alternatives for enzymatic a..
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The usefulness of fecal calprotectin in assessing inflammatory bowel disease activity
Yang Woon Lee, Kang-Moon Lee, Ji Min Lee, Yoon Yung Chung, Dae Bum Kim, Yeon Ji Kim, Woo Chul Chung, Chang-Nyol Paik
Korean J Intern Med. 2019;34(1):72-80. Published online January 20, 2018
Background/Aims: Fecal calprotectin (FC) is known to correlate with disease activity and can be used as a predictor for relapse or treatment response in inflammatory bowel disease (IBD). We evaluated the usefulness of FC as a biomarker for disease activity in patients with IBD using both enzyme-link..
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Infectious diseases
Serum galactomannan levels in the diagnosis of invasive aspergillosis
Yildiz Okuturlar, Fahir Ozkalemkas, Beyza Ener, Sibel Ocak Serin, Esra Kazak, Tulay Ozcelik, Vildan Ozkocaman, Hasan Atilla Ozkan, Halis Akalin, Meral Gunaldi, Ridvan Ali
Korean J Intern Med. 2015;30(6):899-905. Published online October 30, 2015
Background/Aims: In this study, the sensitivity-specificity of galactomannan-enzyme immunoassay (GM-EIA) with a cut-off value of 0.5 for a single, two, or three consecutive positivity in the diagnosis of invasive pulmonary aspergillosis (IPA) in neutropenic patients with hematological malignancy was inves..
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Kinetics of T-cell-based assays on cerebrospinal fluid and peripheral blood mononuclear cells in patients with tuberculous meningitis
Ki-Ho Park, Mi Suk Lee, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Joong Koo Kang, Sang-Ahm Lee, Sung-Han Kim
Korean J Intern Med. 2014;29(6):793-799. Published online October 31, 2014
Background/Aims: The goal of this study was to monitor tuberculosis (TB)-specific T-cell responses in cerebrospinal f luid-mononuclear cells (CSF-MCs) and peripheral blood mononuclear cells (PBMCs) in patients with tuberculous meningitis (TBM) over the course of anti-TB therapy.
Methods: Adult pati..
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