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Allergy / Original Article
Clinical features of moderate-to-severe antibiotic allergy in Korea: analysis from the drug allergy safety information sharing system database
Eunsik Bang, Min-Ho Kang, Jee Hyun Kim, Won Jong Song, Su Jeong Song, Eunyoung Sa, Jeong-Min Park, Ji-Hyang Lee, Jeong-Eun Yun, Jiung Jeong, Sujeong Kim, Hwa Young Lee, Kyung Hee Park, Min-Gyu Kang, Sang Min Lee, So Ri Kim, Sae-Hoon Kim, Hye-Ryun Kang
Korean J Intern Med. 2026;41(6):1141-1151. Published online November 1, 2026
Background/Aims: Antibiotics are major causes of drug allergy. Sharing standardized information on culprit agents is essential to prevent recurrent drug allergy. In 2024, the Ministry of Health and Welfare established the Drug Allergy Safety Information Sharing System (DASI), integrated with the Per..
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Infectious diseases / Original Article
Aspergillus positivity in lower respiratory specimens as a predictor of poor prognosis in invasive pulmonary aspergillosis
Ka Eun Kim, Jung Soo Son, Hyeon Jae Jo, Chan Mi Lee, Jae Hyeon Park, Chang Kyung Kang, Taek Soo Kim, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim
Korean J Intern Med. 2026;41(6):1126-1137. Published online November 1, 2026
Background/Aims: In patients with invasive pulmonary aspergillosis (IPA), the clinical significance of culture positivity is unclear. Here we evaluated whether Aspergillus isolation from lower respiratory tract (LRT) specimens was associated with greater disease severity and higher mortality ..
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Pulmonology / Original Article
Pleural fluid cytokines in malignant pleural effusion: associations with lung expandability and prediction of pleurodesis outcome
Jarudul Phocharoen, Pimpayao Sodsai, Virissorn Wongsrichanalai, Vorawut Thanthitaweewat, Thitiwat Sriprasart, Nophol Leelayuwatanakul
Korean J Intern Med. 2026;41(6):1104-1113. Published online November 1, 2026
Background/Aims: Lung expandability is a key determinant of successful pleurodesis in malignant pleural effusion (MPE). Although pleural elastance is widely used to assess expandability, pleurodesis may still fail in some patients with low elastance. This study investigated pleural fluid cytokines as..
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Gastroenterology / Original Article
Association of age-adjusted skeletal muscle index and modest alcohol intake with hepatic steatosis and fibrosis in males
Janghan Jung, Jin Lee, Dong Hee Koh, Jung Hee Kim
Korean J Intern Med. 2026;41(6):1065-1076. Published online November 1, 2026
Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern linked to obesity, insulin resistance, and metabolic syndrome. Although body composition and alcohol intake influence disease progression, their specific associations with hepatic ste..
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Infectious diseases / Review
Diagnosis and treatment of extrapulmonary tuberculosis in HIV-infected patients: a persistent challenge
Jihwan Bang
Korean J Intern Med. 2026;41(6):1010-1019. Published online November 1, 2026
This review summarizes the current knowledge regarding the epidemiology, diagnostic challenges, and therapeutic considerations of extrapulmonary tuberculosis (EPTB) in HIV-infected patients. Individuals with advanced HIV infection are particularly vulnerable to EPTB and disseminated disease; extrapu..
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Pulmonology / Review
Gastroesophageal reflux disease as a comorbidity in chronic lung diseases: mechanism, clinical impacts and therapeutic uncertainty
Jin-Young Huh, Jin Woo Song
Korean J Intern Med. 2026;41(6):995-1009. Published online November 1, 2026
Chronic lung diseases, particularly chronic obstructive pulmonary disease and interstitial lung disease, are major contributors to global morbidity and mortality. Gastroesophageal reflux disease (GERD) is highly prevalent in these populations and has been implicated in exacerbations and disease prog..
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Pulmonology / Review
Epidemiology of interstitial lung diseases in Asia
Hee-Young Yoon, Felicia S. W. Teo, Ju Hyun Oh, Jin Woo Song
Korean J Intern Med. 2026;41(6):969-981. Published online November 1, 2026
The epidemiology of interstitial lung diseases (ILDs) in Asia has gained increasing attention with the emergence of new population- based datasets and national registries. Current evidence demonstrates that the burden and subtype distribution of ILDs vary considerably across regions, reflecting diff..
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Endocrinology-metabolism / Original Article
Parathyroid hormone–related protein–mediated hypercalcemia of malignancy: insights from a multicenter clinical data warehouse
Jinyoung Kim, Yuri Shin, Jeonghoon Ha, Chaiho Jeong, Jeongmin Lee, Kwanhoon Jo, Jang Won Son, Jae-Seung Yun, Ihnsuk Lee, Dong-Jun Lim, Hyuk-Sang Kwon, Ki-Ho Song, Ki-Hyun Baek
Korean J Intern Med. 2026;41(5):907-915. Published online September 1, 2026
Background/Aims: Parathyroid hormone–related protein (PTHrP) is a major mediator of hypercalcemia in patients with malignancy; however, understanding of PTHrP-mediated hypercalcemia remains limited because available evidence has largely been derived from small case series.
Methods: We retrospectiv..
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Cardiology / Original Article
Prognostic implications of functional significance, high-risk plaque and vessel characteristics in patients with diabetes mellitus
Jin-Eun Song, Seokhun Yang, Masahiro Hoshino, Taishi Yonetsu, Jinlong Zhang, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Jianan Wang, Shaoliang Chen, Nobuhiro Tanaka, Hitoshi Matsuo, Takashi Kubo, Hyuk-Jae Chang, Tsunekazu Kakuta, Bon-Kwon Koo
Korean J Intern Med. 2026;41(5):873-883. Published online September 1, 2026
Background/Aims: We investigated the prognostic value of high-risk plaque (HRP) and high-risk vessel (HRV) characteristics on coronary computed tomography angiography (CCTA) alongside fractional flow reserve (FFR) in patients with diabetes mellitus (DM).
Methods: We analyzed 307 vessels from 184 dia..
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Gastroenterology / Original Article
Clinical feasibility of deep learning-assisted classification of Helicobacter pylori infection in endoscopic imagery: a reader study
Jun-young Seo, Jiseon Kang, Do Hoon Kim, Namkug Kim
Korean J Intern Med. 2026;41(5):862-872. Published online September 1, 2026
Background/Aims: Detecting Helicobacter pylori infection through endoscopic imaging is a preferred method to address the limitations of invasive diagnostics. We have developed a deep learning (DL) model to classify these images based on their H. pylori infection status and to evaluate its pot..
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Pulmonology / Review
Health effects of air pollution on chronic respiratory diseases
Yong Suk Jo, Jin Woo Song
Korean J Intern Med. 2026;41(5):831-846. Published online September 1, 2026
Exposure to both outdoor and indoor air pollution poses significant global public health challenges at all life stages. As the respiratory system serves as the primary entry route for inhaled pollutants, extensive evidence has demonstrated the detrimental effects of various air pollutants on respira..
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Cardiology / Review
Heart failure with preserved ejection fraction in women: a sex-specific clinical review
Soo-Jin Kim, Mi-Seung Shin
Korean J Intern Med. 2026;41(5):819-830. Published online September 1, 2026
Heart failure with preserved ejection fraction (HFpEF) affects approximately half of the current heart failure population and demonstrates marked sex-related differences in pathophysiology, clinical presentation, and therapeutic response. These distinctions reflect the divergent biological pathways ..
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Rheumatology / Original Article
Tumor necrosis factor inhibitor prescribing and persistence by specialty in radiographic axial spondyloarthritis: a Korean claims study
Bon San Koo, Ye-Jee Kim, Yeo-Jin Lee, Yong-Gil Kim, Tae-Hwan Kim
Korean J Intern Med. 2026;41(4):766-778. Published online July 1, 2026
Background/Aims: Although several studies have shown that specialist care may be associated with better outcomes, methodological limitations have made it difficult to draw definitive conclusions. Therefore, we examined real-world patterns of tumor necrosis factor inhibitor (TNFi) use for radiographi..
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Hemato-oncology / Original Article
Restrictive lung function and smoking increase lung cancer risk in tuberculosis survivors: a cohort study
Yun-Gyoo Lee, Hyun-Il Gil, Dayeon Seo, Bo-Guen Kim, Hyunjoo Lee, Young Hwan Kim, Heerim Nam, Soo-Youn Ham, Du-Young Kang, Jae-Uk Song
Korean J Intern Med. 2026;41(4):721-730. Published online July 1, 2026
Background/Aims: Individuals with prior tuberculosis (TB) infection represent a high-risk group for lung cancer due to chronic pulmonary damage. Although associations between TB and lung cancer have been established, this study aimed to explore specific risk factors of lung cancer development in TB ..
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Cardiology / Original Article
Prognostic significance of 1-year versus baseline high-sensitivity C-reactive protein after acute myocardial infarction: nationwide landmark results
Seok-Woo Seong, Hyun Woong Park, Jae-Hwan Lee, Jin-Ok Jeong, Mi Joo Kim, Pil Sang Song, Seon-Ah Jin, Kye Taek Ahn, Myung Ho Jeong, Sang Hyun Park, Jin-Yong Hwang; KAMIR Investigators
Korean J Intern Med. 2026;41(4):690-705. Published online July 1, 2026
Background/Aims: Residual inflammatory risk after acute myocardial infarction (AMI) remains an important determinant of long-term outcomes despite optimal lipid-lowering therapy. The prognostic significance of serial high-sensitivity C-reactive protein (hs-CRP) measurements beyond the acute phase re..
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Gastroenterology / Review
Recent advances in the management of small bowel Crohn’s disease
Kwangwoo Nam, Hee Seok Moon
Korean J Intern Med. 2026;41(4):563-571. Published online July 1, 2026
Crohn’s disease (CD) is a chronic inflammatory disorder of the bowel characterized by alternating periods of remission and relapse. Although CD can affect any part of the gastrointestinal tract, small bowel involvement is particularly common and generally considered a more challenging subtype than..
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Endocrinology-metabolism / Original Article
Does physical activity reduce cardiovascular risk associated with knee osteoarthritis in type 2 diabetes? A nationwide cohort study
Dojoon Park, Kyuho Kim, Hae-Seok Koh, Kyungdo Han, Youn-Ho Choi
Korean J Intern Med. 2026;41(3):485-500. Published online May 1, 2026
Background/Aims: Knee osteoarthritis (OA), type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) share overlapping mechanisms but are often managed independently. We evaluated whether knee OA increases CVD risk in Korean T2DM patients and whether physical activity (PA) modifies this risk..
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Gastroenterology / Original Article
Incidence and risk factors of rebleeding in Crohn’s disease patients with acute lower gastrointestinal bleeding
Gabin Moon, Kyeong Ok Kim, Sung Noh Hong, Seong Joon Koh, Sung Hoon Jung, Chang Hwan Choi, Eun Mi Song, Hong Sub Lee, Yoo Jin Lee, Ki Bae Bang; On behalf of the IBD Research Group of the Korean Association for the Study of Intestinal Diseases
Korean J Intern Med. 2026;41(3):454-461. Published online May 1, 2026
Background/Aims: Acute lower gastrointestinal bleeding (LGIB) in Crohn’s disease (CD) is a rare but potentially life-threatening complication. This study aimed to investigate the incidence and risk factors of rebleeding in CD patients with LGIB.
Methods: We retrospectively analyzed 137 CD patient..
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Gastroenterology / Original Article
Association between remnant cholesterol and colorectal cancer risk in Korea: a nationwide population-based study
Minkook Son, Jong Yoon Lee, Chi Hyeon Choi, Yeo Wool Kang, Sang Yi Moon, Myeonseok Koh
Korean J Intern Med. 2026;41(3):443-453. Published online May 1, 2026
Background/Aims: Remnant cholesterol (RC) has emerged as a novel lipid marker with potential implications in cardiovascular and metabolic diseases. However, its association with colorectal cancer (CRC) remains unclear.
Methods: We conducted a retrospective cohort study using data from 364,626 Korea..
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Gastroenterology / Original Article
Comparison between ligation-assisted and precutting endoscopic mucosal resection for small rectal neuroendocrine tumors: a CHASID study
Sunghyeok Ryou, Yunho Jung, Dae Sung Kim, Hee Seok Moon, Hoon Sup Koo, Hyun Deok Shin, Ki Bae Bang, Kyu Chan Huh; Chungcheong-Daejeon Association for the Study of Intestinal Diseases (CHASID)
Korean J Intern Med. 2026;41(3):432-440. Published online May 1, 2026
Background/Aims: Few studies have compared modified endoscopic mucosal resection (EMR) techniques for small rectal neuroendocrine tumors (NETs). This study evaluated the clinical outcomes of ligation-assisted EMR (EMR-L) and precutting EMR (EMR-P) for the treatment of small rectal NETs.
Methods: We..
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