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Pulmonology / Original Article
The efficacy and safety of DW1601 in patients with acute bronchitis: a multi-center, randomized, double-blind, phase III clinical trial
Young Seok Lee, Seong Yong Lim, Kyung Hoon Min, Do Jin Kim, Kwang Ha Yoo, Tae-Bum Kim, Hak-Ryul Kim, Jae Jeong Shim
Korean J Intern Med. 2022;37(6):1195-1204. Published online September 26, 2022
Background/Aims: DW1601, an oral fixed dose combination syrup composed of DW16011 and Pelargonium sidoides, was developed to enhance the symptom relief effect in patients with acute bronchitis. We evaluated the efficacy and safety of DW1601 compared to DW16011 or P. sidoides for treatm..
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Pulmonology / Original Article
HL301 in the treatment of acute bronchitis: a phase 2b, randomized, double-blind, placebocontrolled, multicenter study
Sang Won Yoon, Myung Jae Park, Chin Kook Rhee, Joo Hun Park, Sang Yeub Lee, Do Jin Kim, Dong Gyu Kim, Jae Yeol Kim
Korean J Intern Med. 2020;35(1):133-141. Published online April 9, 2019
Background/Aims: There is insufficient quality data to recommend the use of herbs for the treatment of acute bronchitis. Small number of randomized trials of plant extracts for this purpose were determined to be low quality and there are concerns for the safety. HL301 is a combined product of seven ..
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Original Article
Efficacy and safety of HL-301 compared with erdosteine in acute bronchitis: a randomized, double-blind, non-inferiority trial
Ji-Yong Moon, Joon Young Choi, Youlim Kim, Hye Jung Park, Yong Bum Park, Seong Yong Lim, Kyung Hoon Min, Deog Kyeom Kim, Chin Kook Rhee, Seung Won Ra, Chang Youl Lee, Yong Il Hwang, Kwang Ha Yoo
Received September 5, 2024 Accepted March 18, 2025 Published online August 26, 2025
Background/Aims: This study evaluated the non-inferiority of HL-301 to erdosteine in terms of symptom relief and the anti- inflammatory effects in acute bronchitis patients not treated with antibiotics.
Methods: In a double-blind, non-inferiority trial, patients were randomized 1:1 to receive eithe..
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