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Cancer treatment-induced bone loss
Yong Jun Choi
Korean J Intern Med. 2024;39(5):731-745. Published online March 5, 2024
Cancer treatment-induced bone loss (CTBL) is associated with anti-tumor treatments, including endocrine therapies, chemotherapeutic treatments, radiotherapy, glucocorticoids, and tyrosine kinase inhibitors. Osteoporosis, characterized by the loss of bone mass, can increase the risk of fractures, lea..
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Endocrinology-metabolism
Efficacy and safety of denosumab treatment for Korean patients with Stage 3b–4 chronic kidney disease and osteoporosis
Jin Taek Kim, You Mi Kim, Kyong Yeun Jung, Hoonsung Choi, So Young Lee, Hyo-Jeong Kim
Korean J Intern Med. 2024;39(1):148-159. Published online December 22, 2023
Background/Aims: We evaluated the efficacy and safety of denosumab treatment in severe chronic kidney disease (CKD) patients with osteoporosis. We also investigated whether the treatment affects the coronary artery calcifications.
Methods: Twenty-seven postmenopausal women with Stage 3b–4 CKD and..
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Rheumatology
Inflammation is responsible for systemic bone loss in patients with seropositive rheumatoid arthritis treated with rituximab
Mie Jin Lim, Kyong-Hee Jung, Seong-Ryul Kwon, Won Park
Korean J Intern Med. 2023;38(6):912-922. Published online October 23, 2023
Background/Aims: We investigated the effect of rituximab on systemic bone metabolism in patients with seropositive rheumatoid arthritis (RA).
Methods: Twenty seropositive patients with RA were enrolled and administered one cycle of rituximab. If RA became active for > 6 months after the first ritux..
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Endocrinology-metabolism
The efficacy of denosumab in Korean male patients with osteoporosis
Chaiho Jeong, Jeonghoon Ha, Jinyoung Kim, Yejee Lim, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Ho Song, Moo Il Kang, Ki-Hyun Baek
Korean J Intern Med. 2022;37(5):1011-1020. Published online June 3, 2022
Background/Aims: Despite the prominence of denosumab as the number one prescribed anti-osteoporosis drug in Korea, the effects of denosumab in male osteoporosis patients were not researched sufficiently. Moreover, concerns on rebound vertebral fractures associated with poor denosumab adherence exist..
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Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates
Yun Sun Lee, So Jeong Park, Jin Young Lee, Eunah Choi, Beom-Jun Kim
Korean J Intern Med. 2022;37(4):821-829. Published online April 26, 2022
Background/Aims: Lumican, a small leucine-rich proteoglycan, has shown osteoprotective effects by synchronously stimulating bone formation and suppressing bone resorption. To clarify the role of lumican in human bone metabolism, the association between lumican concentrations and osteoporosis-related..
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Rheumatology
The usefulness of trabecular bone score in patients with ankylosing spondylitis
Seoung Wan Nam, Yoon-Kyoung Sung, Dam Kim, Soo-Kyung Cho, Yoonah Song, Yun Young Choi, Yongjin Sim, Tae-Hwan Kim
Korean J Intern Med. 2021;36(5):1211-1220. Published online June 30, 2020
Backgrounds/Aims: This study was performed to reveal the usefulness of the trabecular bone score (TBS) in assessing bone strength in patients with ankylosing spondylitis (AS) in comparison with dual-energy X-ray absorptiometry (DXA) methods.
Methods: A total of 215 AS patients (75.8% male) were enr..
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Hemato-oncology
Assessment of bone marrow involvement in patients with lymphoma: report on a consensus meeting of the Korean Society of Hematology Lymphoma Working Party
Yong Park, Byung Bae Park, Ji Yun Jeong, Wook Youn Kim, Seongsoo Jang, Bong Kyung Shin, Dong Soon Lee, Jae Ho Han, Chan-Jeoung Park, Cheolwon Suh, Insun Kim, Hyun-Sook Chi
Korean J Intern Med. 2016;31(6):1030-1041. Published online November 1, 2016
In September 2011, the Korean Society of Hematology Lymphoma Working Party held a nationwide conference to establish a consensus for assessing bone marrow (BM) involvement in patients with lymphoma. At this conference, many clinicians, hematopathologists, and diagnostic hematologists discussed vario..
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Pulmonology
Relationship between pulmonary function and bone mineral density in the Korean National Health and Nutrition Examination Survey
In Seon Lee, Ah Young Leem, Sang Hoon Lee, Yumie Rhee, Yoon Ha, Young Sam Kim
Korean J Intern Med. 2016;31(5):899-909. Published online September 1, 2016
Background/Aims: Osteoporosis is common in chronic obstructive pulmonary disease (COPD) patients. The relationship between osteoporosis and COPD has been primarily reported in patients with moderate to severe COPD, but there is no report in the general population. The aim of this study is to investi..
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Endocrinology-metabolism
Association between household size, residential area, and osteoporosis: analysis of 2008 to 2011 Korea National Health and Nutrition Examination Survey
Sung-Woo Kim, Kwi-Hyun Bae, Jung-Beom Seo, Jae-Han Jeon, Won-Kee Lee, In-Kyu Lee, Jung-Guk Kim, Keun-Gyu Park
Korean J Intern Med. 2016;31(4):712-721. Published online April 15, 2016
Background/Aims: The prevalence of single-person households has rapidly increased in Korea. Individuals living alone and in rural areas may have a higher risk of various metabolic diseases due to differences in lifestyle. However, few studies have investigated the association of household size and r..
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Biomedical Engineering
Hard tissue regeneration using bone substitutes: an update on innovations in materials
Swapan Kumar Sarkar, Byong Taek Lee
Korean J Intern Med. 2015;30(3):279-293. Published online April 29, 2015
Bone is a unique organ composed of mineralized hard tissue, unlike any other body part. The unique manner in which bone can constantly undergo self-remodeling has created interesting clinical approaches to the healing of damaged bone. Healing of large bone defects is achieved using implant materials..
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Rheumatology
Early effects of tumor necrosis factor inhibition on bone homeostasis after soluble tumor necrosis factor receptor use
Mie Jin Lim, Seong Ryul Kwon, Kowoon Joo, Min Jung Son, Shin-Goo Park, Won Park
Korean J Intern Med. 2014;29(6):807-813. Published online October 31, 2014
Background/Aims: Our aim was to assess whether short-term treatment with soluble tumor necrosis factor (TNF) receptor affects circulating markers of bone metabolism in rheumatoid arthritis (RA) patients.
Methods: Thirty-three active RA patients, treated with oral disease-modifying antirheumatic dru..
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The Progression of Bone Mineral Density Loss in Dialysis Patients Compared with the General Population
Petar Avramovski, Aleksandar Sikole
Korean J Intern Med. 2012;27(4):436-442. Published online November 27, 2012
Background/AimsThe aim of this study was to compare the progression of bone mass loss in chronic hemodialysis patients (CHPs) with that in general population patients (GPPs) over an 18-month period. MethodsThe control group consisted of 60 patien..
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Effects of D-003 (10 mg/day) on Bone Mineral Density of the Lumbar Spine and Femoral Neck in Postmenopausal Women: A Randomized, Double-Blinded Study
Alfredo Ceballos, Gladys Castaño, Sarahí Mendoza, Juan González, Rosa Mas, Lilia Fernández, José Illnait, Meilis Mesa, Rafael Gámez, Julio César Fernández, Ricardo Telles, Duany Marrero, Mainel Gómez Eng, Dalmer Ruiz, Yunaisi Jardines
Korean J Intern Med. 2011;26(2):168-178. Published online June 1, 2011
Background/AimsIncreased osteoclast activity is a pivotal finding in osteoporosis. This increase is mediated via the mevalonate-to-cholesterol pathway, which is involved in producing the intermediates required for osteoclast activity. D-003, a mixture of high molecular weight ..
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Predictive Value of Post-Transplant Bone Marrow Plasma Cell Percent in Multiple Myeloma Patients Undergone Autologous Transplantation
In Hye Hwang, Joo Seop Chung, Ho Jin Shin, Young Jin Choi, Moo Kon Song, Young Mi Seol, Goon Jae Cho, Bo Gwang Choi, Mun Ki Choi, Bo Kyung Choi, Kang Hee Ahn, Kyung Hwa Shin, Hee Sun Lee, Hyung Seok Nam, Jong Min Hwang
Korean J Intern Med. 2011;26(1):76-81. Published online March 2, 2011
Background/AimsAutologous stem cell transplantation (ASCT) has become the treatment of choice for patients with multiple myeloma (MM). Studies have shown that maintenance treatment with interferon-alpha is associated with improved survival rates following ASCT. However, despit..
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Bone Marrow T Cells are Superior to Splenic T Cells to Induce Chimeric Conversion After Non-Myeloablative Bone Marrow Transplantation
Hyun-Sil Park, Seok-Goo Cho, Min-Jung Park, So-Youn Min, Hong-Seok Chang, Hee-Je Kim, Seok Lee, Chang-Ki Min, Jong-Wook Lee, Woo-Sung Min, Chun-Choo Kim, Ho-Youn Kim
Korean J Intern Med. 2009;24(3):252-262. Published online August 26, 2009
Background/AimsThe bone marrow functions not only as the primary B-lymphocyte-producing organ but also as a secondary lymphoid organ for CD4 and CD8 cell responses and a site of preferential homing and persistence for memory T cells. Bone marrow T (BM-T) cells are distinguishe..
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A Case of Nonsecretory Multiple Myeloma with Atypical Imaging Features
Hwa Yeon Lee, Seung Min Yoo, In Sup Song, Hyeon Yu, Jong Beum Lee, Jong Wook Shin, In Won Park
Korean J Intern Med. 2006;21(3):202-205. Published online September 30, 2006
Multiple myeloma usually shows homogeneous enhancement on contrast-enhanced Magnetic Resonance imaging (MRI), and is accompanied by a monoclonal gammopathy in serum or urine. We report a case of nonsecretory myeloma, the diagnosis was difficult due to the absence of a monoclonal gammopathy and th..
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