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Pulmonology
Effect of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker on the patients with sepsis
Hyun Woo Lee, Jae Kyung Suh, Eunjin Jang, Sang-Min Lee
Korean J Intern Med. 2021;36(2):371-381. Published online April 9, 2020
Background/Aims: Inhibitors of the renin-angiotensin system, angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs), reportedly have anti-inflammatory effects. This study assessed the association of prior use of ACE inhibitors and ARBs with sepsis-related clinical..
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Cardiology
24-Hour blood pressure response to lower dose (30 mg) fimasartan in Korean patients with mild to moderate essential hypertension
Hae-Young Lee, Cheol-Ho Kim, Jae-Kwan Song, Shung Chull Chae, Myung Ho Jeong, Dong-Soo Kim, Byung-Hee Oh
Korean J Intern Med. 2017;32(6):1025-1036. Published online October 17, 2017
Background/Aims: Fimasartan is an angiotensin type 1 receptor blocker (ARB) which has comparable efficacy and tolerability with other ARBs. The aim of this study was to evaluate 24-hour blood pressure (BP) lowering efficacy and the tolerability of the low dose fimasartan compared with valsartan in p..
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Angiotensin II type 1 receptor blockers as a first choice in patients with acute myocardial infarction
Jang Hoon Lee, Myung Hwan Bae, Dong Heon Yang, Hun Sik Park, Yongkeun Cho, Won Kee Lee, Myung Ho Jeong, Young Jo Kim, Myeong Chan Cho, Chong Jin Kim, Shung Chull Chae, Korea Acute Myocardial Infarction Registry Investigators
Korean J Intern Med. 2016;31(2):267-276. Published online December 23, 2015
Background/Aims: Angiotensin II type 1 receptor blockers (ARBs) have not been adequately evaluated in patients without left ventricular (LV) dysfunction or heart failure after acute myocardial infarction (AMI).
Methods: Between November 2005 and January 2008, 6,781 patients who were not receiving a..
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Nephrology
Angiotensin III increases monocyte chemoattractant protein-1 expression in cultured human proximal tubular epithelial cells
Hyung Wook Kim, Young Ok Kim, Sun Ae Yoon, Jeong-Sun Han, Hyun-Bae Chun, Young Soo Kim
Korean J Intern Med. 2016;31(1):116-124. Published online December 28, 2015
Background/Aims: We investigated whether angiotensin III (Ang III) is involved in monocyte recruitment through regulation of the chemokine monocyte chemoattractant protein-1 (MCP-1) in cultured human proximal tubular epithelial cells (HK-2 cells).
Methods: We measured MCP-1 levels in HK-2 cells tha..
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PPARγ Agonist Beyond Glucose Lowering Effect
Akira Sugawara, Akira Uruno, Masataka Kudo, Ken Matsuda, Chul Woo Yang, Sadayoshi Ito
Korean J Intern Med. 2011;26(1):19-24. Published online March 2, 2011
The nuclear hormone receptor PPARγ is activated by several agonists, including members of the thiazolidinedione group of insulin sensitizers. Pleiotropic beneficial effects of these agonists, independent of their blood glucose-lowering effects, have recently been demonstrated in the vasculature...
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