Gastroenterology / Original Article
Infection of human intestinal epithelial cells by invasive bacteria activates NF-κB and increases ICAM-1 expression through NOD1
Woon Geon Shin, Bum Joon Park, Sung Joong Lee, Jae Gyu Kim
Korean J Intern Med. 2018;33(1):81-90. Published online January 16, 2017
Background/Aims: Nucleotide-binding oligomerization domain 1 (NOD1) is required for primary intestinal epithelial cells (IECs) to respond to natural mucopeptides secreted by gram-negative bacteria. Infection of human IECs with invasive bacteria up-regulates intercellular adhesion molecule-1 (ICAM-1)..
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