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Nephrology
Therapeutic effect of multiple functional minicircle vector encoding anti-CD25/IL-10/CXCR3 in allograft rejection model
Sun Woo Lim, Yoo Jin Shin, Sheng Cui, Eun Jeong Ko, Seok Ho Yoo, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2022;37(5):1031-1049. Published online June 21, 2022
Background/Aims: We previously proposed minicircle vector technology as the potential platform for the development and production of new biologics. In this study, we have designed a novel target molecule for the treatment of allograft rejection and evaluated its feasibility as the therapeutic agent ..
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Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem cell-derived mesenchymal stem cells
Sun Woo Lim, Kyung Woon Kim, Bo Mi Kim, Yoo Jin Shin, Kang Luo, Yi Quan, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2022;37(2):411-424. Published online September 16, 2021
Background/Aims: Renal ischemia followed by reperfusion (I/R) is a leading cause of acute kidney injury (AKI), which is closely associated with high morbidity and mortality. Studies have shown that induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) exert powerful therapeutic..
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Nicotine exacerbates tacrolimus-induced renal injury by programmed cell death
Yu Ji Jiang, Sheng Cui, Kang Luo, Jun Ding, Qi Yan Nan, Shang Guo Piao, Mei Ying Xuan, Hai Lan Zheng, Yong Jie Jin, Ji Zhe Jin, Jung Pyo Lee, Byung Ha Chung, Bum Soon Choi, Chul Woo Yang, Can Li
Korean J Intern Med. 2021;36(6):1437-1449. Published online October 21, 2021
Background/Aims: Cigarette smoking is an important modifiable risk factor in kidney disease progression. However, the underlying mechanisms for this are lacking. This study aimed to assess whether nicotine (NIC), a major toxic component of cigarette smoking, would exacerbates tacrolimus (TAC)-induce..
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Water-soluble coenzyme Q10 provides better protection than lipid-soluble coenzyme Q10 in a rat model of chronic tacrolimus nephropathy
Sheng Cui, Kang Luo, Yi Quan, Sun Woo Lim, Yoo Jin Shin, Kyung Eun Lee, Hong Lim Kim, Eun Jeong Ko, Ju Hwan Kim, Sang J. Chung, Soo Kyung Bae, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2021;36(4):949-961. Published online January 12, 2021
Background/Aims: Coenzyme Q10 (CoQ10), is a promising antioxidant; however, low bioavailability owing to lipid-solubility is a limiting factor. We developed water-soluble CoQ10 (CoQ10-W) and compared its effects with conventional lipid-soluble CoQ10
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The therapeutic efficacy of water-soluble coenzyme Q10 in an experimental model of tacrolimus-induced diabetes mellitus
Yi Quan, Kang Luo, Sheng Cui, Sun Woo Lim, Yoo Jin Shin, Eun Jeong Ko, Ju Hwan Kim, Sang J. Chung, Soo Kyung Bae, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2020;35(6):1443-1456. Published online April 14, 2020
Background/Aims: Coenzyme Q10 (CoQ10) has antioxidant effects and is commercially available and marketed extensively. However, due to its low bioavailability, its effects are still controversial. We developed a water-soluble CoQ10-based micelle formulation (CoQ10-W) ..
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