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Geriatrics
Effects of aging on accompanying intermittent hypoxia in a bleomycin-induced pulmonary fibrosis mouse model
Heayon Lee, In Kyoung Kim, Jeonghyeon Im, Bae Suk Jin, Hwan Hee Kim, Sei Won Kim, Chang Dong Yeo, Sang Haak Lee
Korean J Intern Med. 2023;38(6):934-944. Published online October 5, 2023
Background/Aims: Obstructive sleep apnea (OSA) is prevalent in older patients with idiopathic pulmonary fibrosis (IPF); however, it is underrecognized. OSA is characterized by intermittent hypoxia (IH) and sleep fragmentation. In this study, we evaluated the effects of IH in an older mouse model of..
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Pulmonology
Validity and reliability of the Korean version of the Wisconsin Smoking Withdrawal Scale
Hyonsoo Joo, Hyeon Hui Kang, Hwa Sik Moon, Sang Haak Lee
Korean J Intern Med. 2021;36(1):135-144. Published online February 24, 2020
Background/Aims: This study evaluated the validity and reliability of the Korean version of the Wisconsin Smoking Withdrawal Scale (WSWS-K) for use in clinical practice and research on Korean smokers.
Methods: The Wisconsin Smoking Withdrawal Scale was translated into Korean and then back-translate..
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The health-related quality-of-life of chronic obstructive pulmonary disease patients and disease-related indirect burdens
Hye Sook Choi, Dong-Wook Yang, Chin Kook Rhee, Hyoung Kyu Yoon, Jin Hwa Lee, Seong Yong Lim, Yu-Il Kim, Kwang Ha Yoo, Yong-Il Hwang, Sang Haak Lee, Yong Bum Park
Korean J Intern Med. 2020;35(5):1136-1144. Published online February 20, 2020
Background/Aims: Many chronic obstructive pulmonary disease (COPD) patients have physical limitations. We investigated EuroQol five-dimensions five-level (EQ-5D-5L) of COPD patients to assess quality of life, and assessed indirect burden including time expenditure to visit doctor, home care rate, an..
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Clinical significance of nuclear factor erythroid 2-related factor 2 in patients with chronic obstructive pulmonary disease
Woo Ho Ban, Hyeon Hui Kang, In Kyoung Kim, Jick Hwan Ha, Hyonsoo Joo, Jong Min Lee, Jeong Uk Lim, Sang Haak Lee, Chin Kook Rhee
Korean J Intern Med. 2018;33(4):745-752. Published online March 13, 2018
Background/Aims: Several studies have identified a role for nuclear factor erythroid 2-related factor 2 (Nrf2) in the development of chronic obstructive pulmonary disease (COPD). However, the relationship between the plasma Nrf2 level and the extent of systemic inflammation associated with COPD stat..
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Combination of carboplatin and intermittent normobaric hyperoxia synergistically suppresses benzo[a]pyrene-induced lung cancer
Hea Yon Lee, In Kyoung Kim, Hye In Lee, Hwa Young Lee, Hye Seon Kang, Chang Dong Yeo, Hyun Hui Kang, Hwa Sik Moon, Sang Haak Lee
Korean J Intern Med. 2018;33(3):541-551. Published online December 15, 2017
Background/Aims: We explored the effects of intermittent normobaric hyperoxia alone or combined with chemotherapy on the growth, general morphology, oxidative stress, and apoptosis of benzo[a]pyrene (B[a]P)-induced lung tumors in mice.
Methods: Female A/J mice were given a single dose of B[a]P and ..
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Smoking habits and nicotine dependence of North Korean male defectors
Sei Won Kim, Jong Min Lee, Woo Ho Ban, Chan Kwon Park, Hyoung Kyu Yoon, Sang Haak Lee
Korean J Intern Med. 2016;31(4):685-693. Published online March 8, 2016
Background/Aims: The smoking rates and patterns in the North Korean population are not well known. More than 20,000 North Korean defectors have settled in South Korea; thus, we can estimate the current North Korean smoking situation using this group.
Methods: All North Korean defectors spend their ..
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