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Pulmonology / Original Article
Blood eosinophil count and treatment patterns of chronic obstructive pulmonary disease patients in South Korea using real-world data
Chin Kook Rhee, Yu-Fan Ho, Sumitra Shantakumar, Tim Holbrook, Yein Nam, Kwang‑Ha Yoo
Korean J Intern Med. 2025;40(1):78-91. Published online January 1, 2025
Background/Aims: Chronic obstructive pulmonary disease (COPD) management guidelines have increasingly emphasised the importance of exacerbation prevention, and the role of blood eosinophil count (BEC) as a biomarker for inhaled corticosteroids (ICS) response. This study aimed to describe the distrib..
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Allergy / Original Article
Serum potential biomarkers according to sputum inflammatory cell profiles in adult asthmatics
Gyu-Young Hur, Young-Min Ye, Eunmi Yang, Hae-Sim Park
Korean J Intern Med. 2020;35(4):988-997. Published online November 15, 2019
Background/Aims: Asthma is not a single disease but, rather, a heterogeneous inf lammatory disorder with various pathogenic mechanisms. We analyzed the associations between the cellular profile of sputum and the serum levels of inflammatory mediators/cytokines in a cohort of adult asthmatics.
Metho..
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Review
Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications
Youngwoo Choi, Soyoon Sim, Hae-Sim Park
Korean J Intern Med. 2020;35(4):823-833. Published online May 29, 2020
Asthma is commonly recognized as a heterogeneous condition with a complex pathophysiology. With advances in the development of multiple medications for patients with asthma, most asthma symptoms are well managed. Nevertheless, 5% to 10% of adult asthmatic patients (called severe asthma) are in uncon..
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Gastroenterology / Review
Functional dyspepsia: new insights into pathogenesis and therapy
Nicholas J. Talley
Korean J Intern Med. 2016;31(3):444-456. Published online April 6, 2016
One in 10 people suffer from functional dyspepsia (FD), a clinical syndrome comprising chronic bothersome early satiety, or postprandial fullness, or epigastric pain or burning. Postprandial distress syndrome (PDS, comprising early satiety and/or postprandial fullness) and epigastric pain syndrome (..
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Allergy / Original Article
Association of nasal inflammation and lower airway responsiveness in schoolchildren based on an epidemiological survey
Jun-Ho Myung, Hyun-Jeong Seo, Soo-Jeong Park, Bo-Young Kim, Il-Sang Shin, Jun-Hak Jang, Yun-Kyung Kim, An-Soo Jang
Korean J Intern Med. 2015;30(2):226-231. Published online February 27, 2015
Background/Aims: We sought to increase our understanding of the rhinitis-asthma relationship and improve strategies for the treatment of patients with these diseases. The aim of this study was to identify a connection between upper airway inflammation and lower airway responsiveness.
Methods: We co..
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Review
Prostaglandin D2 and TH2 Inflammation in the Pathogenesis of Bronchial Asthma
Masafumi Arima, Takeshi Fukuda
Korean J Intern Med. 2011;26(1):8-18. Published online March 2, 2011
Prostaglandin D2 (PGD2) is a major prostanoid, produced mainly by mast cells, in allergic diseases, including bronchial asthma. PGD2-induced vasodilatation and increased permeability are well-known classical effects that may be involved in allergic inflammation. R..
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Case Report
Eosinophilic Enteritis Presenting as Intussusception in Adult
Woon Geon Shin, Cheol Hee Park, Young Seok Lee, Kyoung Oh Kim, Kyo-Sang Yoo, Jong Hyeok Kim, Choong Kee Park
Korean J Intern Med. 2007;22(1):13-17. Published online March 31, 2007
Eosinophilic gastroenteritis is defined as a disorder that selectively affects the gastrointestinal tract with eosinophil-rich inflammation in the absence of any known causes for eosinophilia. The clinical manifestations vary according to the site of the eosinophilic infiltrated layer of the bowe..
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