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Hemato-oncology
Pulmonary toxicities of molecular targeted antineoplastic agents: a single-center 10-year experience
Min-Young Lee, Seug Yun Yoon, Kyoung Ha Kim, Namsu Lee, Ha Youn Kim, Jung Hwa Hwang, Jong-Ho Won
Korean J Intern Med. 2021;36(3):689-698. Published online January 8, 2021
Background/Aims: A better understanding of cancer cell biology has led to the discovery and development of several new targeted agents for cancer. These drugs are widely used in cancer treatment and have good toxicity profiles. However, some patients are extremely sensitive to these drugs and can de..
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Pulmonology
Clinical impact of long-term change in air trapping on pulmonary function and computed tomography parameters in chronic obstructive pulmonary disease
Jeong Uk Lim, Jae Seung Lee, Ji-Hyun Lee, Sang-Do Lee, Yeon-Mok Oh, Chin Kook Rhee; for the Korean Obstructive Lung Disease (KOLD) Study Group
Korean J Intern Med. 2021;36(3):636-646. Published online November 25, 2020
Background/Aims: Air trapping is associated with unfavorable outcomes in chronic obstructive pulmonary disease (COPD). The present study evaluated the association between longitudinal changes in air trapping with pulmonary function, computed tomography (CT) parameters and exacerbation.
Methods: Pat..
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Cut-off value of FEV1/FEV6 to determine airflow limitation using handheld spirometry in subjects with risk of chronic obstructive pulmonary disease
Yong Il Hwang, Youlim Kim, Chin Kook Rhee, Deog Kyeom Kim, Yong Bum Park, Kwang Ha Yoo, Ki-Suck Jung, Chang Youl Lee
Korean J Intern Med. 2021;36(3):629-635. Published online June 24, 2020
Background/Aims: Postbronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) less than 0.7 using spirometry is the golden standard to diagnose airf low limitation of chronic obstructive pulmonary disease (COPD). Recently, measuring FEV6 has been s..
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Cardiology
The relationship between miRNA-26b and connective tissue growth factor in rat models of aortic banding and debanding
Jung Sun Cho, Jongho Lee, Ki Cheol Park, Keum-Jin Yang, Eun Joo Cho
Korean J Intern Med. 2021;36(3):596-607. Published online December 30, 2019
Background/Aims: Connective tissue growth factor (CTGF) is a profibrotic factor implicated in pressure overload-mediated myocardial fibrosis. In this study, we determined the role of predicted CTGF-targeting microRNAs (miRNAs) in rat models of aortic stenosis and reverse cardiac remodeling.
Methods..
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Gastroenterology
Effect of Helicobacter pylori treatment on the long-term mortality in patients with type 2 diabetes
Young-Il Kim, Young Ae Kim, Hak Jin Kim, Su-Hyun Kim, Yul Hwangbo, Jae Gyu Kim, Jae J. Kim, Il Ju Choi
Korean J Intern Med. 2021;36(3):584-595. Published online November 25, 2020
Background/Aims: Meta-analyses of randomized trials reported a non-significant increase in overall mortality risk after Helicobacter pylori eradication. In this study, we investigated whether H. pylori treatment is associated with increased risk of overall mortality in patients with ty..
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Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals
Weitao Shen, Jiayu Sun, Zhiyang Li, Fen Yao, Kaihuang Lin, Xiaoyang Jiao
Korean J Intern Med. 2021;36(3):568-583. Published online November 10, 2020
Background/Aim: It is known that an imbalance in the intestinal f lora plays a crucial role in colorectal cancer (CRC), but the effect of food consumption patterns on the types of intestinal flora remains to be clarified. We aimed to analyze the associations between food intake and intestinal flora ..
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Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
Korean J Intern Med. 2021;36(3):557-567. Published online July 7, 2020
Background/Aims: Metabolic syndrome has been reported to be a risk factor for metachronous colorectal neoplasia (CRN). However, the impact of nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, on the development of metachronous CRN after polypectomy has been rar..
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2020 Korean guidelines for the management of metastatic prostate cancer
In-Ho Kim, Sang Joon Shin, Byung Woog Kang, Jihoon Kang, Dalyong Kim, Miso Kim, Jin Young Kim, Chan Kyu Kim, Hee-Jun Kim, Chi Hoon Maeng, Kwonoh Park, Inkeun Park, Woo Kyun Bae, Byeong Seok Sohn, Min-Young Lee, Jae Lyun Lee, Junglim Lee, Seung Taek Lim, Joo Han Lim, Hyun Chang, Joo Young Jung, Yoon Ji Choi, Young Seok Kim, Jaeho Cho, Jae Young Joung, Se Hoon Park, Hyo Jin Lee
Korean J Intern Med. 2021;36(3):491-514. Published online February 10, 2021
In 2017, Korean Society of Medical Oncology (KSMO) published the Korean management guideline of metastatic prostate cancer. This paper is the 2nd edition of the Korean management guideline of metastatic prostate cancer. We updated recent many changes of management in metastatic prostate cancer in th..
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Cardiology
The effect of antiplatelet drug on coronary endothelial and microvascular function: comparison with ticagrelor and clopidogrel
Woong Gil Choi, Gi Chang Kim, Cheol Ho Lee, Hye Young Kim, Dong Woon Kim
Korean J Intern Med. 2021;36(2):352-361. Published online June 23, 2020
Background/Aims: Coronary endothelial and microvascular function play important roles in cardiovascular disease. We aimed to evaluate the effect of ticagrelor on coronary artery function and tested the antiplatelet effect of low dose ticagrelor in East-Asian patients.
Methods: Sixty-one consecutive..
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Gastroenterology
Sex difference in bowel preparation quality and colonoscopy time
Young-Jae Hwang, Dong Woo Shin, Nayoung Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
Korean J Intern Med. 2021;36(2):322-331. Published online June 22, 2020
Background/Aims: The length of colon is known to be longer in females than in males. In addition, the morphology of colon cancer is different between males and females. The aim of this study was to investigate sex differences in Boston bowel preparation score (BBPS) and colonoscopy insertion time.
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Environmental risk factors and comorbidities of primary biliary cholangitis in Korea: a case-control study
Kyung-Ah Kim, Young Seok Kim, Sang Hoon Park, Woo Jin Chung, Dae Hee Choi, Eun Sun Jang, Sook-Hyang Jeong
Korean J Intern Med. 2021;36(2):313-321. Published online March 26, 2020
Background/Aims: The risk factors for the development of primary biliary cholangitis (PBC) is unclear. This study aimed to investigate the risk factors associated with PBC in Korea through a questionnaire survey.
Methods: Consecutively enrolled 103 PBC patients from six referral hospitals and 100 a..
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Risk factors of advanced metachronous neoplasms in surveillance after colon cancer resection
Kwangwoo Nam, Jeong Eun Shin
Korean J Intern Med. 2021;36(2):305-312. Published online April 21, 2020
Background/Aims: Regular surveillance colonoscopy after colon cancer resection is recommended for detecting metachronous adenoma and cancer. However, risk factors for metachronous neoplasms have not been fully evaluated. We aimed to assess risk factors for advanced metachronous neoplasms during surv..
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Comparison of the efficacy and safety of direct-acting antiviral therapy with or without hepatitis C-related hepatocellular carcinoma
Byung Soo Kwan, Jeong Han Kim, Seong Jun Park, Won Hyeok Choe, So Young Kwon, Byung-Chul Yoo
Korean J Intern Med. 2021;36(2):292-304. Published online April 3, 2020
Background/Aims: Chronic hepatitis C (CHC) treatment has dramatically improved since direct-acting antiviral (DAA) therapy was introduced. However, the use of DAA therapy in CHC patients with hepatocellular carcinoma (HCC) remains controversial. We investigated the DAA treatment response in CHC pati..
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Rheumatology
Association of body composition with disease activity and disability in rheumatoid arthritis
Kyeong Min Son, Seong Hun Kang, Young Il Seo, Hyun Ah Kim
Korean J Intern Med. 2021;36(1):214-222. Published online May 15, 2020
Background/Aims: To explore the associations between body composition and pain, disease activity, and disability in rheumatoid arthritis (RA).
Methods: The study enrolled 335 patients with RA and underwent body composition measurement with an InBody analyzer. The associations of body mass index (BM..
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Endocrinology-metabolism
Incidence and risk factors for osteoporotic fractures in patients with systemic lupus erythematosus versus matched controls
Chang Seong Kim, Kyung-Do Han, Jin Hyung Jung, Hong Sang Choi, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Korean J Intern Med. 2021;36(1):154-163. Published online June 26, 2019
Background/Aims: Despite recent improvements in the quality of life of patients with systemic lupus erythematosus (SLE), osteoporosis, and osteoporotic fractures are one of the major complications of SLE. Furthermore, limited data are available on the incidence and predictor of osteoporotic fracture..
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Cardiology
Clinical characteristics of spontaneous coronary artery dissection in young female patients with acute myocardial infarction in Korea
Yongcheol Kim, Xiongyi Han, Youngkeun Ahn, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong
Korean J Intern Med. 2021;36(1):106-113. Published online July 18, 2019
Background/Aims: We aimed to evaluate the prevalence, characteristics, and clinical outcomes of spontaneous coronary artery dissection (SCAD) in young female patients with acute myocardial infarction (AMI).
Methods: We identified 8,250 patients diagnosed with AMI who underwent coronary angiogram fr..
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Gastroenterology
Risk for metabolic syndrome in the population with visceral fat area measured by bioelectrical impedance analysis
Han Ho Jeon, Yong Kang Lee, Dong Hyun Kim, Haeyong Pak, Sang Yun Shin, Jeong Hun Seo
Korean J Intern Med. 2021;36(1):97-105. Published online April 29, 2020
Background/Aims: To investigate whether visceral fat area (VFA) measured by bioelectric impedance analysis (BIA) was associated with metabolic syndrome in subjects with and without obesity.
Methods: A total 23,202 participants who underwent medical check-ups were assessed. Participants were stratif..
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The 2020 revision of the guidelines for the management of myeloproliferative neoplasms
Sung-Yong Kim, Sung Hwa Bae, Soo-Mee Bang, Ki-Seong Eom, Junshik Hong, Seongsoo Jang, Chul Won Jung, Hee-Jin Kim, Ho Young Kim, Min Kyoung Kim, Soo-Jeong Kim, Yeung-Chul Mun, Seung-Hyun Nam, Jinny Park, Jong-Ho Won, Chul Won Choi
Korean J Intern Med. 2021;36(1):45-62. Published online December 4, 2020
In 2016, the World Health Organization revised the diagnostic criteria for myeloproliferative neoplasms (MPNs) based on the discovery of disease-driving genetic aberrations and extensive analysis of the clinical characteristics of patients with MPNs. Recent studies have suggested that additional som..
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Gallstone pancreatitis: general clinical approach and the role of endoscopic retrograde cholangiopancreatography
Shanker Kundumadam, Evan L. Fogel, Mark Andrew Gromski
Korean J Intern Med. 2021;36(1):25-31. Published online January 1, 2021
Gallstones account for majority of acute pancreatitis in the Western world. Increase in number and smaller size of the stones increases the risk for biliary pancreatitis. In addition to features of acute pancreatitis, these patients also have cholestatic clinical picture. Fluid therapy and enteral n..
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Rapid Communication
Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19
Kyoung-Ho Song, Dong-Min Kim, Hyunju Lee, Sin Young Ham, Sang-Min Oh, Hyeonju Jeong, Jongtak Jung, Chang Kyung Kang, Ji Young Park, Yu Min Kang, Ji-Yeon Kim, Jeong Su Park, Kyoung Un Park, Eu Suk Kim, Hong Bin Kim
Korean J Intern Med. 2021;36(1):11-14. Published online November 25, 2020
Recently, the number of patients with coronavirus disease 2019 (COVID-19) who have tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), via the reverse transcription polymerase chain reaction (RT-PCR) test, after recovery has increased; this has caused a dilemma regardin..
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