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Hemato-oncology
BCR-ABL1 transcripts (MR4.5) at post-transplant 3 months as an early predictor for long-term outcomes in chronic myeloid leukemia
Sung-Eun Lee, Soo Young Choi, Soo-Hyun Kim, Hye-Young Song, Hea-Lyun Yoo, Mi-Young Lee, Ki-Hoon Kang, Hee-Jeong Hwang, Eun-Jung Jang, Dong-Wook Kim
Korean J Intern Med. 2017;32(1):125-136. Published online June 22, 2016
Background/Aims: The aim of this study was to identify the role of BCR-ABL1 transcript level as a predictor for post-transplant relapse and outcome in patients who underwent allogeneic stem cell transplantation (SCT) for chronic phase (CP) chronic myeloid leukemia (CML). Methods: Of 101 patients rec..
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Nephrology
Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population
Eunhee Ji, Yon Su Kim
Korean J Intern Med. 2016;31(6):1120-1130. Published online March 25, 2016
Background/Aims: An updated chronic kidney disease (CKD) definition and classification were proposed by Kidney Disease: Improving Global Outcomes (KDIGO), with adoption of a new equation to estimate glomerular filtration rate (GFR) and albuminuria to evaluate kidney structural damage. This study was..
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Duration of anuria predicts recovery of renal function after acute kidney injury requiring continuous renal replacement therapy
Hee-Yeon Jung, Jong-Hak Lee, Young-Jae Park, Sang-Un Kim, Kyung-Hee Lee, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho
Korean J Intern Med. 2016;31(5):930-937. Published online February 12, 2016
Background/Aims: Little is known regarding the incidence rate of and factors associated with developing chronic kidney disease after continuous renal replacement therapy (CRRT) in acute kidney injury (AKI) patients. We investigated renal outcomes and the factors associated with incomplete renal reco..
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Pulmonology
Usefulness of neutrophil to lymphocyte ratio in patients with chronic obstructive pulmonary
disease: a prospective observational study
Seung Jun Lee, Hyang Rae Lee, Tae Won Lee, Sunmi Ju, Sujin Lim, Se-Il Go, Jung-Wan You, Yu Ji Cho, Gyeong-Won Lee, Yi Yeong Jeong, Ho Cheol Kim, Jong Deog Lee
Korean J Intern Med. 2016;31(5):891-898. Published online March 25, 2016
Background/Aims: Neutrophil to lymphocyte ratio (NLR) in peripheral blood is a useful systemic inflammatory response biomarker. However, NLR has not been studied in patients with chronic obstructive pulmonary disease (COPD). This study was aimed to evaluate the usefulness of NLR in patients with COP..
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Nephrology
Clinical value of pathologic examination of non-neoplastic kidney in patients with upper urinary tract malignancies
Jee Wan Wee, Hye Ran Kang, Soon Hyo Kwon, Jin Seok Jeon, Dong Cheol Han, So-Young Jin, Won Jae Yang, Hyunjin Noh
Korean J Intern Med. 2016;31(4):739-749. Published online May 30, 2016
Background/Aims: While surgical resection remains the standard of care in the treatment of upper urinary tract malignancies, nephrectomy is a risk factor for the development of chronic kidney disease (CKD). The aim of this study was to determine whether histologic evaluation of non-neoplastic kidney..
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Hemato-oncology
Chronic lymphocytic leukemia: a clinical review including Korean cohorts
Young-Woo Jeon, Seok-Goo Cho
Korean J Intern Med. 2016;31(3):433-443. Published online April 5, 2016
Only 5th decade ago, chronic lymphocytic leukemia (CLL) was only recognized as disease group of presenting features like peripheral lymphocytosis, organomegaly including of splenomegaly. As understanding of disease biology and molecular diagnostic tools are getting improved gradually, characterizati..
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Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
Dae Sik Kim, Yoo Jin Na, Myoung Hee Kang, Soo-Young Yoon, Chul Won Choi
Korean J Intern Med. 2016;31(2):357-366. Published online February 15, 2016
Background/Aims: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed, and a substantial number of patients need alternative treatment ..
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Nephrology
Advanced chronic kidney disease: a strong risk factor for Clostridium difficile infection
Sun Chul Kim, Min Young Seo, Jun Yong Lee, Ki Tae Kim, Eunjung Cho, Myung-Gyu Kim, Sang-Kyung Jo, Won-Yong Cho, Hyoung-Kyu Kim
Korean J Intern Med. 2016;31(1):125-133. Published online December 28, 2015
Background/Aims: It has been suggested that chronic kidney disease (CKD) is a risk factor for Clostridium difficile infection (CDI) and is associated with increased mortality among patients infected with C. difficile. However, recent studies of the clinical impact of CKD on CDI in Asia..
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Predicting postoperative total calcium requirements after parathyroidectomy in secondary hyperparathyroidism
Byung Heon Kang, Soon Young Hwang, Jeong Yeop Kim, Yu Ah Hong, Mi Yeon Jung, Eun Ah Lee, Ji Eun Lee, Jae Bok Lee, Gang Jee Ko, Heui Jung Pyo, Young Joo Kwon
Korean J Intern Med. 2015;30(6):856-864. Published online October 30, 2015
Background/Aims: To prevent hypocalcemia after parathyroidectomy (PTX), parenteral calcium is required in addition to oral calcitriol and calcium. After switching to oral calcium, patients can be discharged from the hospital. The aim of this study was to analyze the clinical characteristics and outc..
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Gastroenterology
Incidence of and risk factors for thyroid dysfunction during peginterferon α and ribavirin treatment in patients with chronic hepatitis C
Yong Hwang, Won Kim, So Young Kwon, Hyung Min Yu, Jeong Han Kim, Won Hyeok Choe
Korean J Intern Med. 2015;30(6):792-800. Published online October 30, 2015
Background/Aims: Thyroid dysfunction (TD) is more likely to occur in patients with chronic hepatitis C (CHC) and is particularly associated with interferon (IFN) treatment. The purpose of this study was to investigate the incidence, outcomes, and risk factors for TD during pegylated interferon (PEG-..
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Nephrology
Time points for obtaining representative values of 24-hour blood pressure in chronic kidney disease
Jiwon Ryu, Ran-hui Cha, Dong Ki Kim, Ju Hyun Lee, Sun Ae Yoon, Dong Ryeol Ryu, Jieun Oh, Sejoong Kim, Sang-Youb Han, Eun Young Lee, Yon Su Kim
Korean J Intern Med. 2015;30(5):665-674. Published online August 27, 2015
Background/Aims: Ambulatory blood pressure (BP) monitoring has been widely recommended for evaluating the status of BP, but is lacking in practicality. Determination of the specific time points for BP measurement that are representative of 24-hour mean BP could be useful and convenient in hypertensi..
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Pulmonology
Chronic obstructive pulmonary disease (COPD) assessment test scores corresponding to modified Medical Research Council grades among COPD patients
Chang-Hoon Lee, Jinwoo Lee, Young Sik Park, Sang-Min Lee, Jae-Joon Yim, Young Whan Kim, Sung Koo Han, Chul-Gyu Yoo
Korean J Intern Med. 2015;30(5):629-637. Published online August 27, 2015
Background/Aims: In assigning patients with chronic obstructive pulmonary disease (COPD) to subgroups according to the updated guidelines of the Global Initiative for Chronic Obstructive Lung Disease, discrepancies have been noted between the COPD assessment test (CAT) criteria and modified Medical ..
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Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome
Chin Kook Rhee
Korean J Intern Med. 2015;30(4):443-449. Published online June 29, 2015
Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or fixed AO and bronchial hyperresponsiveness can be considered t..
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Nephrology
Plasma neutrophil gelatinase-associated lipocalin as a potential predictor of adverse renal outcomes in immunoglobulin A nephropathy
Ga-Young Park, Chung-Hoon Yu, Jun-Seop Kim, Yun-Jeong Kang, Owen Kwon, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park
Korean J Intern Med. 2015;30(3):345-353. Published online April 29, 2015
Background/Aims: Neutrophil gelatinase-associated lipocalin (NGAL) is a well-known biomarker of acute kidney injury. We evaluated the value of plasma NGAL (pNGAL) as an independent predictor of prognosis in immunoglobulin A nephropathy (IgAN).
Methods: In total, 91 patients with biopsy-proven IgAN ..
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Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients
Wan Soo Lee, Dae Woong Kang, Jong Hun Back, Hyun Lee Kim, Jong Hoon Chung, Byung Chul Shin
Korean J Intern Med. 2015;30(2):198-204. Published online February 27, 2015
Background/Aims: Serum procalcitonin (PCT) levels are low in healthy individuals but are elevated in patients with a serious bacterial infection or sepsis. In this study, we examined the ability of serum PCT concentration to diagnose infections in end-stage renal disease (ESRD) patients, and sought ..
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Pulmonology
Awareness of chronic obstructive pulmonary disease in current smokers: a nationwide survey
So Yeong Mun, Yong Il Hwang, Joo Hee Kim, Sunghoon Park, Seung Hun Jang, Jae Yong Seo, Ja Kyung Kim, Yong Bum Park, Jae Jung Shim, Ki-Suck Jung
Korean J Intern Med. 2015;30(2):191-197. Published online February 27, 2015
Background/Aims: Cigarette smoking is the most common risk factor for chronic obstructive pulmonary disease (COPD). However, few studies of the attitudes toward COPD of smokers, the group at risk of developing this condition, have been conducted. The purpose of this study was to explore the awarenes..
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Gastroenterology
Long-term virological outcome in chronic hepatitis B patients with a partial virological response to entecavir
Yu Jung Jo, Kyung-Ah Kim, June Sung Lee, Nam-Hoon Kim, Won Ki Bae, Tae June Song, Jeong Wook Kim
Korean J Intern Med. 2015;30(2):170-176. Published online February 27, 2015
Background/Aims: The clinical outcome of patients with a partial virological response (PVR) to entecavir (ETV), in particular nucloes(t)ide analogue (NA)-experienced patients, has not been thoroughly investigated. The aim of the present study was to assess long-term outcomes in NA-naive and NA-exper..
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Pulmonology
Proteomic differences with and without ozone-exposure in a smoking-induced emphysema lung model
Soo-Taek Uh, So-My Koo, An Soo Jang, Sung Woo Park, Jae Sung Choi, Yong-Hoon Kim, Choon Sik Park
Korean J Intern Med. 2015;30(1):62-72. Published online December 30, 2014
Background/Aims: Acute exacerbations in chronic obstructive pulmonary disease may be related to air pollution, of which ozone is an important constituent. In this study, we investigated the protein profiles associated with ozone-induced exacerbations in a smoking-induced emphysema model.
Methods: M..
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Gastroenterology
Long-term efficacy of tenofovir disoproxil fumarate therapy after multiple nucleos(t)ide analogue failure in chronic hepatitis B patients
Hyo Jin Kim, Ju-Yeon Cho, Yu Jin Kim, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Kwang Cheol Koh, Seung Woon Paik, Byung Chul Yoo, Joon Hyeok Lee
Korean J Intern Med. 2015;30(1):32-41. Published online December 30, 2014
Background/Aims: The efficacy of tenofovir disoproxil fumarate (TDF) for the treatment of chronic hepatitis B (CHB) patients following prior treatment failure with multiple nucleos(t)ide analogues (NAs) is not well defined, especially in Asian populations. In this study we investigated the efficacy ..
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Nephrology
Major changes and improvements of dialysis therapy in Korea: review of end-stage renal disease registry
Dong Chan Jin
Korean J Intern Med. 2015;30(1):17-22. Published online December 30, 2014
The Korean Society of Nephrology (KSN) launched a nationwide end-stage renal disease (ESRD) patient registry in 1985 called the Insan Prof. Byung-Suk Min Memorial ESRD Patient Registry. KSN members voluntarily participate in this registry, which has been collecting data through the Internet since 20..
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