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Nephrology / Original Article
Low waist circumference prior to percutaneous coronary intervention predict the risk for end-stage renal disease: a nationwide Korean population based-cohort study
Eun Hui Bae, Sang Yup Lim, Eun Mi Yang, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Bongseong Kim, Kyung-Do Han, Soo Wan Kim
Korean J Intern Med. 2022;37(3):639-652. Published online February 11, 2022
Background/Aims: The obesity paradox has been known in end-stage renal disease (ESRD). However, the effect of body mass index (BMI) or waist circumference (WC) prior to percutaneous coronary intervention (PCI) on the development of ESRD is not clear.
Methods: Using nationally representative data fr..
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Pulmonology / Original Article
Acute exacerbation of COPD increases the risk of hip fractures: a nested case-control study from the Korea National Health Insurance Service
Kang-Mo Gu, Sang-Won Yoon, Sun-Young Jung, Moon Seong Baek, Won Young Kim, Jae-Woo Jung, Jae-Chol Choi, Jong-Wook Shin, Jae-Yeol Kim, Byoung-Whui Choi, In-Won Park
Korean J Intern Med. 2022;37(3):631-638. Published online February 8, 2022
Background/Aims: Hip fracture and acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) could increase mortality in patients with COPD. There are no data on the relationship between AE-COPD and hip fracture, which may significantly affect the prognosis of patients with COPD. Therefor..
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Review
Emotional and cognitive changes in chronic kidney disease
Duk-Soo Kim, Seong-Wook Kim, Hyo-Wook Gil
Korean J Intern Med. 2022;37(3):489-501. Published online March 8, 2022
Chronic kidney disease (CKD) leads to cognitive impairment and emotional changes. However, the precise mechanism underlying the crosstalk between the kidneys and the nervous system is not fully understood. Inflammation and cerebrovascular disease can influence the development of depression in CKD. C..
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Pulmonology / Original Article
Prevalence and impact of airway diseases on clinical outcomes in idiopathic pulmonary fibrosis
Heemoon Park, Jaeyoung Cho, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sun Mi Choi
Korean J Intern Med. 2022;37(2):387-397. Published online December 7, 2021
Background/Aims: The prevalence and effects of airway diseases, including asthma, eosinophilic bronchitis (EB), chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO) have not been thoroughly studied in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to evalu..
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Pulmonology / Original Article
Korean physician prescription patterns for home oxygen therapy in chronic obstructive pulmonary disease patients
Youlim Kim, Hwan Il Kim, Ji Young Park, Ji Young Hong, Joo-Hee Kim, Kyung Hoon Min, Chin Kook Rhee, Sunghoon Park, Chang Youl Lee, Seong Yong Lim, Seung Hun Jang, Yong Il Hwang
Korean J Intern Med. 2022;37(1):119-126. Published online August 20, 2021
Background/Aims: Hypoxemia in chronic obstructive pulmonary disease (COPD) leads to reduced ability to exercise, decreased quality of life, and, eventually, increased mortality. Home oxygen therapy in patients with severe COPD reduces distress symptoms and mortality rates. However, there have been fe..
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Review
Current status of the diagnosis of chronic pancreatitis by ultrasonographic elastography
Kazunori Nakaoka, Senju Hashimoto, Ryoji Miyahara, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Takamichi Kuwahara, Hiroyuki Tanaka, Yoshiki Hirooka
Korean J Intern Med. 2022;37(1):27-36. Published online December 15, 2021
Chronic pancreatitis (CP) is pathologically characterized by the loss of exocrine pancreatic parenchyma, irregular fibrosis, cellular infiltration, and ductal abnormalities. Diagnosing CP objectively is difficult because standard diagnostic criteria are insufficient. The change of parenchymal hardne..
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Hemato-oncology / Original Article
Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells
Yoo Jin Na, Eun Sang Yu, Dae Sik Kim, Dae-Hee Lee, Sang Cheul Oh, Chul Won Choi
Korean J Intern Med. 2021;36(Suppl 1):S196-S206. Published online April 3, 2020
Background/Aims: Nilotinib is used for treating patients with imatinib-sensitive or -resistant chronic myeloid leukemia (CML); however, nilotinib-resistant cases have been observed in recent years. In addition, a considerable number of patients receiving nilotinib developed diabetes. Metformin is a ..
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Hemato-oncology / Original Article
Survival impact of adherence to tyrosine kinase inhibitor in chronic myeloid leukemia
Yundeok Kim, Tae-Hwa Go, Jaeyeon Jang, Jii Bum Lee, Seung Taek Lim, Kwang Yong Shim, Jong In Lee, Jee Hyun Kong
Korean J Intern Med. 2021;36(6):1450-1458. Published online November 1, 2021
Background/Aims: Adherence to tyrosine kinase inhibitors (TKIs) has become a critical aspect of care in chronic myeloid leukemia (CML). We aimed to examine the association of TKI adherence with overall survival (OS) outcomes in Korean patients diagnosed with CML and treated with TKIs using data from..
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Review
Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma
Andrew Li, Hiang Ping Chan, Phyllis X.L. Gan, Mei Fong Liew, W.S. Fred Wong, Hui-Fang Lim
Korean J Intern Med. 2021;36(6):1305-1319. Published online October 12, 2021
Approximately 25% to 40% of patients with chronic obstructive pulmonary disease (COPD) have the eosinophilic endotype. It is important to identify this group accurately because they are more symptomatic and are at increased risk for exacerbations and accelerated decline in forced expiratory volume i..
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Review
Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease
Naoya Tanabe, Toyohiro Hirai
Korean J Intern Med. 2021;36(6):1294-1304. Published online October 6, 2021
Chronic obstructive pulmonary disease (COPD) is a complex lung disease characterized by a combination of airway disease and emphysema. Emphysema is classified as centrilobular emphysema (CLE), paraseptal emphysema (PSE), or panlobular emphysema (PLE), and airway disease extends from the respiratory,..
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Review
Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease
Yousuf Waheed, Fan Yang, Dong Sun
Korean J Intern Med. 2021;36(6):1281-1293. Published online July 8, 2021
Previous research has investigated whether hyperuricemia serves as an independent risk factor for cardiovascular and renal diseases. Hyperuricemia is defined as an abnormally high level of uric acid (UA; i.e., serum urate level > 6.8 mg/dL). Hyperuricemia has been considered a complication of chroni..
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Pulmonology / Original Article
Patterns of medical care utilization according to environmental factors in asthma and chronic obstructive pulmonary disease patients
Eun-Jung Jo, Min-Hyeok Choi, Chang-Hoon Kim, Kyung-Mi Won, Yoo-Keun Kim, Ju-Hee Jeong, Hye Yeon An, Mi-Kyoung Hwang, Hye-Kyung Park
Korean J Intern Med. 2021;36(5):1146-1156. Published online February 10, 2021
Background/Aims: Weather and air pollution are associated with the exacerbation of respiratory diseases. We investigated patterns of medical care use according to meteorological factors and air pollution in patients with asthma or chronic obstructive pulmonary disease (COPD).
Methods: We analyzed t..
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Nephrology / Original Article
Role of Akt1 in renal fibrosis and tubular dedifferentiation during the progression of acute kidney injury to chronic kidney disease
Il Young Kim, Yeon Kyeong Park, Sang Heon Song, Eun Young Seong, Dong Won Lee, Sun Sik Bae, Soo Bong Lee
Korean J Intern Med. 2021;36(4):962-974. Published online December 16, 2020
Background/Aims: Acute kidney injury (AKI) is an underestimated yet important risk factor for the development of chronic kidney disease (CKD), characterized by tubulointerstitial fibrosis and tubular dedifferentiation. Tubular dedifferentiation, which is associated with the loss of epithelial marker..
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Endocrinology-metabolism / Original Article
Weight change and microvascular outcomes in patients with new-onset diabetes: a nationwide cohort study
Eun Sil Koh, Kyung Do Han, Mee Kyoung Kim, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
Korean J Intern Med. 2021;36(4):932-941. Published online May 13, 2021
Background/Aims: Because weight control is important in treatment of type 2 diabetes, it is essential to understand the associations between weight change and the risk of microvascular complications among patients with type 2 diabetes. We examined whether weight changes early after new-onset diabete..
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Review
How important is dietary management in chronic kidney disease progression? A role for low protein diets
Gang-Jee Ko, Kamyar Kalantar-Zadeh
Korean J Intern Med. 2021;36(4):795-806. Published online June 22, 2021
High dietary protein intake may lead to increased intraglomerular pressure and glomerular hyperfiltration, which in the long-term can lead to de novo or aggravating preexisting chronic kidney disease (CKD). Hence, a low protein diet (LPD, 0.6 to 0.8 g/kg/day) is recommended for the management of CKD..
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Review
Blood pressure control in patients with chronic kidney disease
Jee Young Lee, Seung Hyeok Han
Korean J Intern Med. 2021;36(4):780-794. Published online June 22, 2021
Uncontrolled blood pressure (BP) in patients with chronic kidney disease (CKD) can lead to serious adverse outcomes. To prevent the occurrence of cardiovascular events (CVEs), and end-stage kidney disease, achieving an optimal BP level is important. Recently, there has been a paradigm shift in the m..
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Nephrology / Original Article
Effect of urinary angiotensinogen and high-salt diet on blood pressure in patients with chronic kidney disease: results from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD)
Ha Yeon Kim, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Su-Ah Sung, Seung Hyeok Han, Kook-Hwan Oh, Curie Ahn, Soo Wan Kim
Korean J Intern Med. 2021;36(3):659-667. Published online October 8, 2020
Background/Aims: This study aimed to investigate whether urinary angiotensinogen (UAGT) excretion was associated with elevated blood pressure in patients with chronic kidney disease (CKD) and to evaluate the relationship among blood pressure, intra-renal renin-angiotensin system (RAS) activity, and ..
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Pulmonology / Original Article
Clinical impact of long-term change in air trapping on pulmonary function and computed tomography parameters in chronic obstructive pulmonary disease
Jeong Uk Lim, Jae Seung Lee, Ji-Hyun Lee, Sang-Do Lee, Yeon-Mok Oh, Chin Kook Rhee; for the Korean Obstructive Lung Disease (KOLD) Study Group
Korean J Intern Med. 2021;36(3):636-646. Published online November 25, 2020
Background/Aims: Air trapping is associated with unfavorable outcomes in chronic obstructive pulmonary disease (COPD). The present study evaluated the association between longitudinal changes in air trapping with pulmonary function, computed tomography (CT) parameters and exacerbation.
Methods: Pat..
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Pulmonology / Original Article
Cut-off value of FEV1/FEV6 to determine airflow limitation using handheld spirometry in subjects with risk of chronic obstructive pulmonary disease
Yong Il Hwang, Youlim Kim, Chin Kook Rhee, Deog Kyeom Kim, Yong Bum Park, Kwang Ha Yoo, Ki-Suck Jung, Chang Youl Lee
Korean J Intern Med. 2021;36(3):629-635. Published online June 24, 2020
Background/Aims: Postbronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) less than 0.7 using spirometry is the golden standard to diagnose airf low limitation of chronic obstructive pulmonary disease (COPD). Recently, measuring FEV6 has been s..
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Gastroenterology / Original Article
The predictors of sustained virological response with sofosbuvir and ribavirin in patients with chronic hepatitis C genotype 2
Sung Yong Han, Hyun Young Woo, Jeong Heo, Sang Gyu Park, Sung Ik Pyeon, Young Joo Park, Dong Uk Kim, Gwang Ha Kim, Hyung Hoi Kim, Geun Am Song, Mong Cho
Korean J Intern Med. 2021;36(3):544-556. Published online March 19, 2019
Background/Aims: Real-world, clinical practice data are lacking about sofosbuvir/ ribavirin (SOF/RBV) treatment of Korean patients with hepatitis C virus genotype 2 (HCV GT2) infection. This study investigated the efficacy and safety of SOF/RBV in Korean patients with HCV GT2 infection and clinical ..
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