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Hemato-oncology / Original Article
Nutritional status in the era of target therapy: poor nutrition is a prognostic factor in non-small
cell lung cancer with activating epidermal growth factor receptor mutations
Sehhoon Park, Seongyeol Park, Se-Hoon Lee, Beomseok Suh, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Young Whan Kim, Dae Seog Heo
Korean J Intern Med. 2016;31(6):1140-1149. Published online March 28, 2016
Background/Aims: Pretreatment nutritional status is an important prognostic factor in patients treated with conventional cytotoxic chemotherapy. In the era of target therapies, its value is overlooked and has not been investigated. The aim of our study is to evaluate the value of nutritional status ..
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Pulmonology / Original Article
Glomerular filtration rate affects interpretation of pulmonary function test in a Korean general population: results from the Korea National Health and Nutrition Examination Survey 2010 to 2012
Young Soo Kim, Hee Yeon Kim, Hyo-Suk Ahn, Tae Seo Sohn, Jae Yen Song, Young Bok Lee, Dong-Hee Lee, Jae-Im Lee, Tae-Kyu Lee, Seong Cheol Jeong, Mihee Hong, Hiun Suk Chae, Kyungdo Han, Chang Dong Yeo
Korean J Intern Med. 2016;31(6):1101-1109. Published online March 21, 2016
Background/Aims: The pulmonary abnormalities (principally restrictive abnormalities) are characteristic of renal transplant recipients or those with end-stage renal disease. Our aim was to explore whether the prevalence of spirometric abnormalities was influenced by the estimated glomerular filtrati..
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Gastroenterology / Original Article
Ten-year experience of esophageal endoscopic submucosal dissection of superficial esophageal neoplasms in a single center
Hyung Chul Park, Do Hoon Kim, Eun Jeong Gong, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Jin-Ho Kim
Korean J Intern Med. 2016;31(6):1064-1072. Published online September 13, 2016
Background/Aims: Endoscopic submucosal dissection (ESD) of a superficial esophageal neoplasm (SEN) is a technically difficult procedure. We investigated the clinical outcomes of ESD to determine its feasibility and effectiveness for the treatment of SEN.
Methods: Patients who underwent ESD for SEN ..
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Gastroenterology / Review
Gastric cancer and family history
Yoon Jin Choi, Nayoung Kim
Korean J Intern Med. 2016;31(6):1042-1053. Published online November 1, 2016
Gastric cancer is associated with high morbidity and mortality rates worldwide. Identifying individuals at high risk is important for surveillance and prevention of gastric cancer. Having first-degree relatives diagnosed with gastric cancer is a strong and consistent risk factor for gastric cancer, ..
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Infectious diseases / Original Article
Opportunistic diseases among HIV-infected patients: a multicenter-nationwide Korean HIV/AIDS cohort study, 2006 to 2013
Youn Jeong Kim, Jun Hee Woo, Min Ja Kim, Dae Won Park, Joon-Young Song, Shin Woo Kim, Jun Yong Choi, June Myung Kim, Sang Hoon Han, Jin-Soo Lee, Bo Youl Choi, Joo Shil Lee, Sung-Soon Kim, Mee-Kyung Kee, Moon Won Kang, Sang Il Kim
Korean J Intern Med. 2016;31(5):953-960. Published online April 27, 2016
Background/Aims: The frequencies of opportunistic diseases (ODs) vary across countries based on genetic, environmental, and social differences. The Korean HIV/AIDS cohort study was initiated in 2006 to promote research on human immunodeficiency virus (HIV) infection in Korea, and to provide a logist..
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Nephrology / Original Article
Determinants and burden of chronic kidney disease in a high-risk population in Korea: results from a cross-sectional study
Yong Un Kang, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Korean J Intern Med. 2016;31(5):920-929. Published online January 13, 2016
Background/Aims: This study aimed to investigate the prevalence of chronic kidney disease (CKD) and associated risk factors in a high-risk population in Korea.
Methods: A total of 6,045 participants aged ≥ 65 years (mean age, 73.0 ± 5.5) with diabetes or hypertension were enrolled. Participants w..
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Pulmonology / Original Article
Relationship between pulmonary function and bone mineral density in the Korean National Health and Nutrition Examination Survey
In Seon Lee, Ah Young Leem, Sang Hoon Lee, Yumie Rhee, Yoon Ha, Young Sam Kim
Korean J Intern Med. 2016;31(5):899-909. Published online September 1, 2016
Background/Aims: Osteoporosis is common in chronic obstructive pulmonary disease (COPD) patients. The relationship between osteoporosis and COPD has been primarily reported in patients with moderate to severe COPD, but there is no report in the general population. The aim of this study is to investi..
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Pulmonology / Original Article
Usefulness of neutrophil to lymphocyte ratio in patients with chronic obstructive pulmonary
disease: a prospective observational study
Seung Jun Lee, Hyang Rae Lee, Tae Won Lee, Sunmi Ju, Sujin Lim, Se-Il Go, Jung-Wan You, Yu Ji Cho, Gyeong-Won Lee, Yi Yeong Jeong, Ho Cheol Kim, Jong Deog Lee
Korean J Intern Med. 2016;31(5):891-898. Published online March 25, 2016
Background/Aims: Neutrophil to lymphocyte ratio (NLR) in peripheral blood is a useful systemic inflammatory response biomarker. However, NLR has not been studied in patients with chronic obstructive pulmonary disease (COPD). This study was aimed to evaluate the usefulness of NLR in patients with COP..
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Cardiology / Original Article
Prognostic value of computed tomographic coronary angiography and exercise electrocardiography for cardiovascular events
Kye-Hwan Kim, Kyung Nyeo Jeon, Min Gyu Kang, Jong Hwa Ahn, Jin-Sin Koh, Yongwhi Park, Seok-Jae Hwang, Young-Hoon Jeong, Choong Hwan Kwak, Jin-Yong Hwang, Jeong Rang Park
Korean J Intern Med. 2016;31(5):880-890. Published online March 25, 2016
Background/Aims: This study is a head-to-head comparison of predictive values for long-term cardiovascular outcomes between exercise electrocardiography (ex-ECG) and computed tomography coronary angiography (CTCA) in patients with chest pain.
Methods: Four hundred and forty-two patients (mean age, ..
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Gastroenterology / Original Article
Endoscopic submucosal dissection of gastric subepithelial tumors: a systematic review and
meta-analysis
Chang Seok Bang, Gwang Ho Baik, In Soo Shin, Ki Tae Suk, Jai Hoon Yoon, Dong Joon Kim
Korean J Intern Med. 2016;31(5):860-871. Published online February 22, 2016
Background/Aims: To evaluate the therapeutic outcomes of the endoscopic submucosal dissection (ESD) technique for the treatment of gastric subepithelial tumors (SETs).
Methods: A systematic literature review was conducted using the core databases. Data on the complete resection rates and the proced..
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Review
Endoscopic gastritis, serum pepsinogen assay, and Helicobacter pylori infection
Sun-Young Lee
Korean J Intern Med. 2016;31(5):835-844. Published online September 1, 2016
Endoscopic findings of the background gastric mucosa are important in the Helicobacter pylori-seroprevalent population. It is strongly correlated not only with the risk of gastric cancer, but also with the excretion ability of gastric mucosa cells. In noninfected subjects, common endoscopic f..
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Hemato-oncology / Review
Optimal maintenance and consolidation therapy for multiple myeloma in actual clinical practice
Ho Sup Lee, Chang-Ki Min
Korean J Intern Med. 2016;31(5):809-819. Published online September 1, 2016
Multiple myeloma is an incurable malignant plasma cell-originating cancer. Although its treatment outcomes have improved with the use of glucocorticoids, alkylating drugs, and novel agents, including proteasome inhibitors (bortezomib and carfilzomib) and immunomodulatory drugs (thalidomide, lenalido..
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Letter to the editor
Ectopic ACTH syndrome caused by pulmonary carcinoid tumor mimicking long-standing sclerosing hemangioma
Sung Yong Han, Bo Hyun Kim, Hee Ryeong Jang, Won Jin Kim, Yun Kyung Jeon, Sang Soo Kim, In Ju Kim
Korean J Intern Med. 2016;31(4):794-797. Published online January 28, 2016
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Letter to the editor
Intermittent, subtle change of ST segment in narrow QRS regular tachycardia
Hyeong Won Seo, Hyung Wook Park, Ki Hong Lee, Joon-Ho Ahn, Ji Eun Yu, Nam Sik Yoon, Jeong Gwan Cho
Korean J Intern Med. 2016;31(4):791-793. Published online June 17, 2016
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Infectious diseases / Original Article
Incidence and risk factors of hepatitis C virus infection among human immunodeficiency virus
(HIV) patients in a large HIV clinic in South Korea
Shinwon Lee, Sun Hee Lee, Su Jin Lee, Kye-Hyung Kim, Jeong Eun Lee, Heerim Cho, Seung Geun Lee, Joo Seop Chung, Ihm Soo Kwak
Korean J Intern Med. 2016;31(4):772-778. Published online April 27, 2016
Background/Aims: Increasing incidences of hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-infected men who have sex were reported in the United States and Europe. However, few studies regarding the epidemiology of HCV infection in HIV-infected patients in Asian countries have..
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Nephrology / Original Article
Clinical value of pathologic examination of non-neoplastic kidney in patients with upper urinary tract malignancies
Jee Wan Wee, Hye Ran Kang, Soon Hyo Kwon, Jin Seok Jeon, Dong Cheol Han, So-Young Jin, Won Jae Yang, Hyunjin Noh
Korean J Intern Med. 2016;31(4):739-749. Published online May 30, 2016
Background/Aims: While surgical resection remains the standard of care in the treatment of upper urinary tract malignancies, nephrectomy is a risk factor for the development of chronic kidney disease (CKD). The aim of this study was to determine whether histologic evaluation of non-neoplastic kidney..
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Nephrology / Original Article
Tumor necrosis factor α is a risk factor for infection in peritoneal dialysis patients
Eunjung Kang, Seihran Kim, Hwa Jung Lee, Inhwee Park, Heungsoo Kim, Gyu-Tae Shin
Korean J Intern Med. 2016;31(4):722-729. Published online March 22, 2016
Background/Aims: It has been shown that circulating tumor necrosis factor α (TNF-α) is elevated in end stage renal disease patients; however, the relationship between TNF-α and the development of infection in these patients is unknown. In this study, we investigated the association of plasma TNF-..
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Pulmonology / Original Article
Neuron-specific enolase as a novel biomarker reflecting tuberculosis activity and treatment
response
Sung-Jin Nam, Jee-Yeong Jeong, Tae-Won Jang, Mann-Hong Jung, Bong-Kwon Chun, Hee-Jae Cha, Chul-Ho Oak
Korean J Intern Med. 2016;31(4):694-702. Published online June 3, 2016
Background/Aims: It is not clear which tests are indicative of the activity and severity of tuberculosis (TB). This study aimed to investigate the predictive value of neuron-specific enolase (NSE) and to determine the origin of NSE in TB patients.
Methods: A single-center retrospective analysis was..
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Pulmonology / Original Article
Smoking habits and nicotine dependence of North Korean male defectors
Sei Won Kim, Jong Min Lee, Woo Ho Ban, Chan Kwon Park, Hyoung Kyu Yoon, Sang Haak Lee
Korean J Intern Med. 2016;31(4):685-693. Published online March 8, 2016
Background/Aims: The smoking rates and patterns in the North Korean population are not well known. More than 20,000 North Korean defectors have settled in South Korea; thus, we can estimate the current North Korean smoking situation using this group.
Methods: All North Korean defectors spend their ..
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Gastroenterology / Original Article
Is height a risk factor for colorectal adenoma?
Jeung Hui Pyo, Sung Noh Hong, Byung-Hoon Min, Dong Kyung Chang, Hee Jung Son, Poong-Lyul Rhee, Jae J. Kim, Young-Ho Kim
Korean J Intern Med. 2016;31(4):653-659. Published online December 23, 2015
Background/Aims: Although it is generally known that the risk for all types of cancer increases with adult height, combined and for several common site-specific cancers (including colon and rectal), evidence is limited for adenomas, which are precursors to colorectal cancer. We evaluated the associa..
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