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Nephrology / Review
Vitamin D and chronic kidney disease
Chang Seong Kim, Soo Wan Kim
Korean J Intern Med. 2014;29(4):416-427. Published online June 27, 2014
Chronic kidney disease (CKD) has been recognized as a significant global health problem because of the increased risk of total and cardiovascular morbidity and mortality. Vitamin D deficiency or insufficiency is common in patients with CKD, and serum levels of vitamin D appear to have an inverse cor..
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Gastroenterology / Review
Diet, microbiota, and inflammatory bowel disease: lessons from Japanese foods
Takanori Kanai, Katsuyoshi Matsuoka, Makoto Naganuma, Atsushi Hayashi, Tadakazu Hisamatsu
Korean J Intern Med. 2014;29(4):409-415. Published online June 27, 2014
The incidence and prevalence of inflammatory bowel diseases (IBDs) including ulcerative colitis and Crohn disease are rapidly increasing in Western countries and in developed Asian countries. Although biologic agents targeting the immune system have been effective in patients with IBD, cessation of ..
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Case Report
Acute esophageal necrosis occurring in a patient undergoing percutaneous coronary intervention
Hyung-Jin Kwon, Sang-Ho Park, Ji-Hoon Ahn, Tae-Hoon Lee, Chang-Kyun Lee
Korean J Intern Med. 2014;29(3):379-382. Published online April 29, 2014
Acute esophageal necrosis is uncommon in the literature. Its etiology is unknown, although cardiovascular disease, hemodynamic compromise, gastric outlet obstruction, alcohol ingestion, hypoxemia, hypercoagulable state, infection, and trauma have all been suggested as possible causes. A 67-year-old ..
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Letter to the editor
A case of primary aldosteronism presenting as non-ST elevation myocardial infarction
Ja Min Byun, Suk Chon, Soo-Joong Kim
Korean J Intern Med. 2013;28(6):739-742. Published online October 29, 2013
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Case Report
Postinfectious Guillain-Barre syndrome in a patient with methimazole-induced agranulocytosis
Yoon Young Cho, Ji Young Joung, Hyemin Jeong, Dongmo Je, Yun Soo Hong, Sunghwan Suh, Sun Wook Kim
Korean J Intern Med. 2013;28(6):724-727. Published online October 29, 2013
Both Graves disease and Guillain-Barre syndrome (GBS) are autoimmune disorders caused by impaired self-tolerance mechanisms and triggered by interactions between genetic and environmental factors. GBS in patients who suffer from other autoimmune diseases is rarely reported, and the development of..
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Nephrology / Original Article
Serum osteoprotegerin is associated with vascular stiffness and the onset of new cardiovascular events in hemodialysis patients
Jung Eun Lee, Hyung Jong Kim, Sung Jin Moon, Ji Sun Nam, Jwa-Kyung Kim, Seung Kyu Kim, Gi Young Yun, Sung Kyu Ha, Hyeong Cheon Park
Korean J Intern Med. 2013;28(6):668-677. Published online October 29, 2013
Background/AimsOsteoprotegerin (OPG) and fetuin-A are vascular calcification regulators that may be related to high cardiovascular (CV) mortality in hemodialysis (HD) patients. We evaluated the relationship between OPG, fetuin-A, and pulse wave velocity (PWV), a marker of vasc..
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Endocrinology-metabolism / Original Article
Neuroprotective effects of Vitis vinifera extract on prediabetic mice induced by a high-fat diet
Heung Yong Jin, Youn Soo Cha, Hong Sun Baek, Tae Sun Park
Korean J Intern Med. 2013;28(5):579-586. Published online August 14, 2013
Background/AimsVitis vinifera grape seed extract (VVE) contains oligomeric proanthocyanidins that show antioxidant and free radical-scavenging activities. We evaluated VVE for its neuroprotective effect in prediabetic mice induce by a high-fat diet (HD).
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Nephrology / Original Article
Renal outcomes and clinical course of nondiabetic renal diseases in patients with type 2 diabetes
Ja Min Byun, Cheol Hyun Lee, Sul Ra Lee, Ju Young Moon, Sang Ho Lee, Tae Won Lee, Chun Gyoo Ihm, Kyung Hwan Jeong
Korean J Intern Med. 2013;28(5):565-572. Published online August 14, 2013
Background/AimsIn several recent studies, renal biopsies in patients with type 2 diabetes and renal disease have revealed a heterogeneous group of disease entities. Our aim was to study the prognosis and clinical course of nondiabetic renal disease (NDRD) and to determine risk..
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Cardiology / Original Article
Impact of family history on the presentation and clinical outcomes of coronary heart disease: data from the Korea Acute Myocardial Infarction Registry
Choongki Kim, Hyuk-Jae Chang, Iksung Cho, Ji Min Sung, Donghoon Choi, Myung Ho Jeong, Yang Soo Jang,
Korean J Intern Med. 2013;28(5):547-556. Published online August 14, 2013
Background/AimsFamily history (FHx) of coronary heart disease (CHD) is a well-known risk factor for CHD. However, the prognostic implication of FHx has not been established clearly in patients with acute myocardial infarction (AMI). MethodsIn t..
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Gastroenterology / Original Article
Effects of D-002, a mixture of high molecular weight beeswax alcohols, on patients with nonalcoholic fatty liver disease
José Illnait, Iván Rodríguez, Sarahí Mendoza, Yolanda Fernández, Rosa Mas, Mirtha Miranda, Jesús Piñera, Julio César Fernández, Meilis Mesa, Lilia Fernández, Daisy Carbajal, Rafael Gámez
Korean J Intern Med. 2013;28(4):439-448. Published online July 1, 2013
Background/AimsNonalcoholic fatty liver disease (NAFLD) is intimately related to insulin resistance and ranges from a benign course to liver fibrosis and cirrhosis. NAFLD management mainly involves dietary modification and weight loss. Although no fully successful pharmacologi..
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Hemato-oncology / Review
Clinical applications of mesenchymal stem cells
Nayoun Kim, Seok-Goo Cho
Korean J Intern Med. 2013;28(4):387-402. Published online July 1, 2013
Mesenchymal stem cells (MSCs) are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into cell types of mesodermal origin, such as adipocytes, osteocytes, and chondrocytes. In addition, MSCs can migrate to sites of inflammation and exert potent immunosuppress..
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Letter to the editor
A case of polymyositis associated with Hashimoto's thyroiditis
Shi Jung Sung, Se Jin Hwang, Jong Min Kim, Young Am Lee, Ji Seon Oh, Jae Hee Suh, Seung Won Choi
Korean J Intern Med. 2013;28(3):380-382. Published online May 1, 2013
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Case Report
A case of hemophagocytic syndrome in a patient with fulminant ulcerative colitis superinfected by cytomegalovirus
Jun Il Mun, Sung Jae Shin, Byung Hyun Yu, Jee Hoon Koo, Dong Hoon Kim, Ki Myoung Lee, Kwang Jae Lee
Korean J Intern Med. 2013;28(3):352-355. Published online May 1, 2013
Hemophagocytic syndrome (HPS) is an uncommon hematological disorder that manifests as fever, splenomegaly, and jaundice, with hemophagocytosis in the bone marrow and other tissues pathologically. Secondary HPS is associated with malignancy and infection, especially viral infection. The prevalence..
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Rheumatology / Original Article
Is the frequency of metabolic syndrome higher in South Korean women with rheumatoid arthritis than in healthy subjects?
Seung-Geun Lee, Ji-Min Kim, Sun-Hee Lee, Kye-Hyung Kim, Ji-Hye Kim, Ji-Won Yi, Woo-Jin Jung, Young-Eun Park, Seong-Hu Park, Joung-Wook Lee, Seung-Hoon Baek, Jun-Hee Lee, Geun-Tae Kim
Korean J Intern Med. 2013;28(2):206-215. Published online February 27, 2013
Background/AimsTo compare the frequency of metabolic syndrome (MetS) and magnitude of insulin resistance, measured by the homeostatic model assessment of insulin resistance (HOMA-IR), between South Korean women with rheumatoid arthritis (RA) and healthy subjects, and to evalua..
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Case Report
Type B insulin-resistance syndrome presenting as autoimmune hypoglycemia, associated with systemic lupus erythematosus and interstitial lung disease
Seon Mee Kang, Heung Yong Jin, Kyung Ae Lee, Ji Hyun Park, Hong Sun Baek, Tae Sun Park
Korean J Intern Med. 2013;28(1):98-102. Published online December 28, 2012
We describe an unusual case of systemic lupus erythematosus with pulmonary manifestations presenting as hypoglycemia due to anti-insulin receptor antibodies. A 38-year-old female suffered an episode of unconsciousness and was admitted to hospital where her blood glucose was found to be 18 mg/dL. ..
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Nephrology / Original Article
Tissue Doppler-derived E/e' ratio as a parameter for assessing diastolic heart failure and as a predictor of mortality in patients with chronic kidney disease
Min Keun Kim, Biro Kim, Jun Young Lee, Jae Seok Kim, Byoung-Geun Han, Seung Ok Choi, Jae Won Yang
Korean J Intern Med. 2013;28(1):35-44. Published online December 28, 2012
Background/AimsDiastolic dysfunction occurs frequently in patients with chronic kidney disease (CKD) and is associated with heart failure (HF) or mortality. We investigated whether the ratio of early diastolic mitral inflow velocity to early diastolic mitral annulus velocity (..
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Cardiology / Review
Physiologic approach for coronary intervention
William F. Fearon
Korean J Intern Med. 2013;28(1):1-7. Published online December 28, 2012
When invasively assessing coronary artery disease, the primary goal should be to determine whether the disease is causing a patient's symptoms and whether it is likely to cause future cardiac events. The presence of myocardial ischemia is our best gauge of whether a lesion is responsible for symp..
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Letter to the editor
Pelvic Bone Fractures Mimicking Bone Metastases in a Patient with Hepatitis B Virus-Associated Liver Cirrhosis and Hepatocellular Carcinoma
Dong Hyeon Lee, Eun Sun Jang, Hong Sang Oh, Kwang Hyun Chung, Eun Hyo Jin, Eu Jeong Ku, Eun Roh
Korean J Intern Med. 2012;27(4):467-469. Published online November 27, 2012
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Case Report
Langerhans Cell Histiocytosis Followed by Hodgkin's Lymphoma
IK Soo Park, In Keun Park, Eun Kyoung Kim, Shin Kim, Sang Ryong Jeon, Joo Ryung Huh, Cheol Won Suh
Korean J Intern Med. 2012;27(4):459-462. Published online November 27, 2012
A 22-year-old man was referred to our institution due to lower back pain and was diagnosed with Langerhans cell histiocytosis of the thoracic and lumbar spine. The patient achieved complete remission with radiotherapy and chemotherapy. One year later, right cervical lymphadenopathy was observed a..
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Original Article
Patient's Perception of Symptoms Related to Morning Activity in Chronic Obstructive Pulmonary Disease: The SYMBOL Study
Yeon Jae Kim, Byung Ki Lee, Chi Young Jung, Young June Jeon, Dae Sung Hyun, Kyung Chan Kim, Sung Ken Yu, Hye Sook Choi, Won Hyuk Shin, Kwan Ho Lee
Korean J Intern Med. 2012;27(4):426-435. Published online November 27, 2012
Background/AimsPatients with chronic obstructive pulmonary disease (COPD) experience more problematic respiratory symptoms and have more trouble performing daily activities in the morning. The aim of this study was to assess the perception of COPD symptoms related to morning a..
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