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Gastroenterology
The effect of rebamipide on non-steroidal anti-inflammatory drug-induced gastro-enteropathy: a multi-center, randomized pilot study
Dong Jun Oh, Hyuk Yoon, Hyun Soo Kim, Yoon Jin Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, You-Jung Ha, Eun Ha Kang, Yun Jong Lee, Nayoung Kim, Ki-Jeoung Kim, Fei Liu
Korean J Intern Med. 2022;37(6):1153-1166. Published online November 1, 2022
Background/Aims: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly-used medications, and ailments such as arthritis or heart disease, require long-term use of these drugs, which can induce gastroenteropathy with bleeding and ulcers. This study investigated the associations between efficacy..
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Rectal NSAIDs-based combination modalities are superior to single modalities for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a network meta-analysis
Tae Young Park, Hyun Kang, Geun Joo Choi, Hyoung-Chul Oh
Korean J Intern Med. 2022;37(2):322-339. Published online February 16, 2022
Background/Aims: Different modalities have been employed to reduce the risk and severity of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). However, there has been a paucity of studies comparing the efficacy of various prophylactic modalities for preventing PEP. This n..
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Desensitization for the prevention of drug hypersensitivity reactions
Sung-Yoon Kang, Jeongmin Seo, Hye-Ryun Kang
Korean J Intern Med. 2022;37(2):261-270. Published online February 28, 2022
Drug desensitization is the temporary induction of tolerance to a sensitized drug by administering slow increments of the drug, starting from a very small amount to a full therapeutic dose. It can be used as a therapeutic strategy for patients with drug hypersensitivity when no comparable alternativ..
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Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs
Tae Young Park, Hyoung-Chul Oh, Evan L. Fogel, Glen A. Lehman
Korean J Intern Med. 2020;35(3):535-543. Published online April 29, 2020
Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the frequency and severity of this complication. Recently, the use of rectal non-steroid..
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Gastroenterology
The efficacy and safety of irsogladine maleate in nonsteroidal anti-inflammatory drug or aspirin-induced peptic ulcer and gastritis
Ki-Nam Shim, Jin Il Kim, Nayoung Kim, Sang Gyun Kim, Yun Ju Jo, Su Jin Hong, Jeong Eun Shin, Gwang Ha Kim, Kyung Sik Park, Suck Chei Choi, Joong Goo Kwon, Jie-Hyun Kim, Hyun Jin Kim, Ji Won Kim
Korean J Intern Med. 2019;34(5):1008-1021. Published online June 1, 2018
Background/Aims: Irsogladine maleate, an enhancer of gastric mucosal protective factors, has demonstrated its efficacy for various gastric mucosal injuries. The aim of this study was to evaluate the efficacy and safety of irsogladine for prevention of nonsteroidal anti-inflammatory drugs (NSAIDs) or..
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Allergy
What we know about nonsteroidal anti-inflammatory drug hypersensitivity
Duy Le Pham, Ji-Hye Kim, Tu Hoang Kim Trinh, Hae-Sim Park
Korean J Intern Med. 2016;31(3):417-432. Published online March 31, 2016
Nonsteroidal anti-inf lammatory drugs (NSAIDs) are widely prescribed for the treatment of inflammatory diseases, but their use is frequently related to hypersensitivity reactions. This review outlines our current knowledge of NSAID hypersensitivity (NHS) with regard to its pathogenic, molecular, and..
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Gastroenterology
Can postendoscopic retrograde cholangiopancreatography pancreatitis be prevented by a pharmacological approach?
Young Koog Cheon
Korean J Intern Med. 2013;28(2):141-148. Published online February 27, 2013
Acute pancreatitis remains the most frequent complication of endoscopic retrograde cholangiopancreatography (ERCP), with reported incidence rates that have changed little over several decades. Patient- and procedure-related risk factors for post-ERCP pancreatitis (PEP) are well-defined. Effective..
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