Role of IL-1α in Cisplatin-Induced Acute Renal Failure in Mice
Jay-Wook Lee, Woo-Jin Nam, Min-Jee Han, Jung-Ho Shin, Jin-Gun Kim, Su-Hyun Kim, Hye-Ryoun Kim, Dong-Jin Oh
Korean J Intern Med. 2011;26(2):187-194. Published online June 1, 2011
Background/AimsFor unknown reasons, caspase-1 -/- mice, protected against cisplatin-induced acute renal failure (ARF), are deficient in interleukin (IL)-1α. We thus asked whether IL-1α deficiency underlies the mechanism of protection against cisplatin-induced ARF in these mic..
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