Effect of IgA Aggregates on Transforming Growth Factor-β1 Production in Human Mesangial Cells and the Intraglomerular Expression of Transforming Growth Factor-β1 in Patients with IgA Nephropathy
Sang-Youb Han, Chun-Gyoo Ihm, Dae-Ryong Cha, Young-Sun Kang, Kum-Hyun Han, Hyoung-Kyu Kim, Jee-Young Han
Korean J Intern Med. 2005;20(1):40-47. Published online March 31, 2005
BackgroundTransforming growth factor-β (TGF-β) stimulates renal fibrosis in various renal diseases including IgA nephropathy. MethodsWe examined whether immunoglobulin A (IgA) stimulated TGF-β1 synthesis in human mesangial cells (MCs), and whe..
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