1. Rose MC, Kaufman B, Martin BM. Proteolytic fragmentation and peptide mapping of human carboxyamidomethylated trracheobronchial mucin. J Biol Chem 264:8193–81991989.
3. Carpenter G, Cohen S. Epidermal growth factor. J Biol Chem 265:7709–77121990.
4. Tsang F, Wong WSF. Inhibitors of tyrosine kinase signaling cascade attenuated antigen challenge of Guinea-pig airways in vitro. Am J Respir Crit Care Med 162:126–1332000.
6. Ullrich A, Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell 61:203. 1990.
7. Takeyama K, Fahy JV, Nadel JA. Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. Am J Respir Crit Care Med 163:511. 2001.
8. Wu W, Graves LM, Jaspers I, Devlin RB, Reed W, Samet JM. Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals. Am J Physiol 277:L924–L9311999.
9. Zanella CL, Timblin CR, Cummins A, Jung M, Goldberg J, Raabe R, Tritton T, Mossman BT. Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis. Am J Physiol 277:L684–L6931999.
10. Shim JJ, Dabbagh K, Ueki IF, Dao-Pick T, Burgel PR, Takeyama K, Tarn DCW, Nadel JA. IL-13 induces mucin production by stimulating epidermal growth factor receptors and activating neutrophils. Am J Physiol 280:L134–L1402000.
11. Meerzaman D, Charles P, Daskal E, Polymeropoulos MH, Martin BM, Rose MC. Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5AC). J Biol Chem 269:12932–129391994.
13. Shin CY, Kang SJ, Kim KC, Ko KH. Comparison between ELISA and gel-filtration assay for the quantitation of airway mucins. Arch Pharm Res 21:253–2591998.
15. Dohrman A, Miyata S, Gallup M, Li JD, Chapelin C, Coste A, Escudier E, Nadel J, Basbaum C. Mucin gene (MUC2 and MUC5AC) upregulation by gram-positive and gram-negative bacteria. Biochem Biophy Acta 1406:251–2591998.
16. Coles SJ, Levine LR, Reid L. Hypersecretion of mucus glycoproteins in rat airways induced by tobacco smoke. Am J Pathol 94:459–4721979.
17. Borchers MT, Wert SE, Leikauf GD. Acrolein-induced MUC5ac expression in rat airways. Am J Physiol 274(Lung Cell Mol Physiol 18):L573–L5811998.
18. Li JD, Gallup M, Fan N, Szymkowski DE, Basbaum CB. Cloning the amino-terminal and 5’-flanking region of the human MUC5AC mucin gene and the transcriptional up-regulation by bacterial exoproducts. J Biol Chem 273:6812–68201998.
19. Voynow J, Young LR, Wang Y, Horger T, Rose M, Fischer BM. Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol 276(Lung Cell Mol Physiol 20):L835–L8431999.
20. Basbaum C, Lemjabbar H, Longphre M, Gensch E, McNamara N. Control of mucin transcription by diverse injury-induced signaling pathways. Am J Respir Crit Care Med 160:S44–S481999.
21. Bae YS, Kang SW, Seo MS, Bainess IC, Tekle E, Chock PB, Rhee SG. Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. J Biol Chem 272:217–2211997.
22. Larivee P, Levine SJ, Rieves RD, Shelhamer H. Airway inflammation and mucus hypersecretion. Airway secretion: Physiological Basis for the Control of Mucus Hypersecretion. In: Takishima T, Shimura S, eds. Marcel Dekker, New York: 469–511.
23. Levine SJ, Larivee P, Logun C, Angus W, Ognibene FP, Shelhamer JH. Tumor necrosis factor-α induces mucin secretion and MUC-2 gene expression by human airway epithelial cells. Am J Respir Cell Mol Biol 12:196–2041995.
24. Dwyer T, Farley JM. Human neutrophil elastase releases two pools of mucin-like glycoconjugate from submucosal gland cells. Am J Physiol Lung Cell Mol Physiol 278:L675–L6822000.
25. Komori M, Inoue H, Matsumoto K, Koto H, Fukuyama S, Aizawa H, Hara N. PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways. Am J Physiol Lung Cell Mol Physiol 280:L436. L441. 2001.
26. Lou YP, Takeyama K, Grattan KM, Lausier J, Ueki IF, Agusti C, Nadel JA. Platelet-activating factor induces goblet cell hyperplasia and mucin gene expression in airways. Am J Respir Crit Care Med 157:1927–19341998.