A 78-year-old male treated for pneumonia was referred to the cardiology department after post-cardiopulmonary resuscitation due to torsades de pointes (TdP) (Fig. 1A). The laboratory findings revealed an increased N-terminal probrain natriuretic peptide level of 569 pg/mL (normal range < 125 pg/mL) and an increased troponin-I level of 0.47 ng/mL (normal range < 0.04 ng/mL). With the cessation of ciprofloxacin, after an electrolyte correction and lidocaine infusion, the TdP episodes were no longer observed. Four days later, a follow-up electrocardiogram (ECG) (Fig. 1B) revealed a beat-to-beat macroscopic T-wave alternans (TWA) with an alternating change in the QT interval. Echocardiography revealed apical ballooning compatible with takotsubo cardiomyopathy (TCM). Considering his precarious condition, coronary angiography was not performed. Despite intensive combination antibiotic therapy, his pneumonia progressed, and he died.