A 64-year-old female was admitted to the hospital with complaints of recurrent non-intensive right-sided pain, facial petechiae, 20,2-pound weight loss over the past 10 months. Her physical examination revealed palmar erythema, liver 3 cm below costal margin, non-palpable spleen. Laboratory test results showed leukocytosis, increased level total bilirubin, conjugated bilirubin, aspartate aminotransferase, gamma-glutamyl transpeptidase, alkaline phosphatase, and total cholesterol. The urinalysis showed albumin negative. Abdominal ultrasonography and computed tomography scan with contrast showed considerable hepatosplenomegaly with moderate diffuse parenchymal changes (steatosis) of the liver and pancreas without any sighs of portal hypertension. Upper gastrointestinal endoscopy revealed palatal petechiae, multiple shallow ulcers covered with fibrin along the entire length of the esophagus with mucosal friability, spontaneous hemorrhage, atrophic gastritis with erosions and regions of intestinal metaplasia with erosions of the duodenal mucosa (Fig. 1). Histopathological examination of esophageal and gastric mucosa biopsy demonstrated diffuse eosinophilic deposition within the lamina propria of mucosa, muscularis mucosa, and vessels walls in the submucosa. Staining of the specimens with Congo red for amyloid deposits was strongly positive (Fig. 2). The results of ultrasound-guided liver biopsy revealed amorphous material stained by Congo red stain demonstrating characteristic positive birefringence under polarized light. λ-Light chains (ALs) were identified by immunohistochemical analysis. AL amyloidosis was confirmed. Treatment with bortezomib, melphalan, and dexamethasone was prescribed.