Following the coronavirus disease 2019 (COVID-19) outbreak in China, a sudden regional COVID-19 outbreak occurred in Daegu, South Korea [1]. The surge of confirmed COVID-19 patients may influence the treatment modality for patients who visit the emergency room (ER) presenting with abdominal pain, gastrointestinal bleeding, acute cholangitis, or foreign body impaction in the gastrointestinal tract. The highly virulent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is well known to be transmitted via the respiratory tract by aerosol droplets. However, fecal to oral transmission has been postulated; therefore, endoscopy may pose a risk for transmission [2]. Protection of medical workers and prevention of viral spread to other patients are critical issues that need to be monitored while performing endoscopic procedures in the endoscopy room, ER, and intensive care unit of tertiary hospitals [3,4]. More than 10,765 patients tested positive for SARS-CoV-2 from February 18, 2020 to April 30, 2020 in South Korea with most cases originating from a specific religious group within Daegu. During this period, most routine endoscopies were canceled or postponed in order to prevent nosocomial spread, based on the infection control policy of Yeungnam University Hospital [3]. There is no available guideline for endoscopy in the ER of a tertiary hospital during the COVID-19 pandemic. Therefore, we set up an algorithm as a guide for conducting endoscopy, including gastrofibroscopy, sigmoidoscopy, colonoscopy, and endoscopic retrograde cholangiopancreatography (ERCP) (Fig. 1). Those who visited the ER immediately underwent screening for fever and respiratory symptoms (cough, sputum, or sore throat) and intensive history-taking on whether the patient is a Shinchungi religious churchgoer, recent visit to China, or a close contact episode with a SARS-CoV-2-positive patient. Those who had fever, respiratory symptoms, or a pertinent history underwent reverse-transcription polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 using throat and nose swabs and/or sputum, which takes approximately 4 to 6 hours to obtain results on weekdays and 12 hours on weekends. While waiting for RT-PCR results, patients were transferred to an isolated or negative pressure room. Patients suspected of having COVID-19 infection and necessitated to undergo emergency endoscopy due to hematemesis, foreign body exposure, or ongoing cholangitis subsequently underwent emergency endoscopy based on clinicians’ discretion. All endoscopies for patients suspected of having COVID-19 infection and without confirmed negative RT-PCR results were performed under level D protection. From February 18, 2020 to April 30, 2020, a total of 130 patients underwent endoscopy through the ER in our center: ERCP was performed in 54 cases, gastrofibroscopy in 67 cases, colonoscopy in three cases, and sigmoidoscopy in nine cases. Endoscopy was performed under level D protection in two patients. Among these 130 patients, 40 (30.8%) had fever and respiratory symptoms or possibility of a close contact episode with a SARS-CoV-2-positive patient. Only one patient who was initially afebrile was diagnosed with COVID-19 14 days after ERCP. Performing endoscopy is a major challenge during the viral outbreak [3-5]. All patients were required to wear masks before and after gastrofibroscopy or ERCP and were only unmasked while undergoing gastrofibroscopy or ERCP. All medical personnel in endoscopy units wear personal protective equipment including N95 mask, hair cap, two layers of surgical gloves, goggles, face shield, waterproof gown, and shoe covers when performing emergent endoscopy in patients with fever, respiratory symptoms or those who had possible close contact episodes with SARS-CoV-2-positive patients and without SARS-CoV-2 RT-PCR results (Fig. 2) [2-4]. As per the infection control guidelines in our center, the endoscopy room was disinfected and ventilated for an hour after completing the endoscopy.