A 32-year-old woman was admitted to the hospital with recurrent moderate pain in the epigastrium and the right side after eating, along with constipation, periodic diarrhea, and eructation. The patient had a medical history of irritable bowel syndrome with mixed bowel habits; she had limited food intake because of abdominal pain in the previous 2 years. The patient had no unhealthy habits (no alcohol, tobacco, oral, or intravenous drug abuse), her medication intake history excluded sunitinib and dabigatran; and she had no autoimmune disorders. Her physical examination revealed a low body mass index (15.7 kg/m²). No rash, hematomas, or petechiae were present on the skin. Laboratory examinations, abdominal ultrasonography, and colonoscopy with histopathological examination of colon and small-bowel mucosal biopsy yielded unremarkable findings. Upper gastrointestinal endoscopy revealed longitudinal sloughing and detachment of mucosa in the lower thoracic esophagus with mild redness after separation of mucosa by a distal end portion of an endoscope (Fig. 1). There were no signs of bleeding or perforation after it, biopsy was performed simultaneously. Histopathological examination of the biopsy specimen demonstrated an esophageal squamous epithelium dissected in upper layers with parakeratosis, cavity formation, and slight infiltration of leukocytes. Dysplasia, pleomorphism and mitotic figures were absent. Staining of the specimen with periodic acid-Schiff stain for fungal colonies yielded negative results (Fig. 2). Exfoliative esophagitis was confirmed. She was treated by drip infusion of a proton pump inhibitor, enteral nutrition, and metabolic supplements, and positive effects were achieved.