Subsequent renal angiography demonstrated a classical "string of beads" appearance of both the renal arteries (saccular dilatations and constrictions) that spared the ostium; this was suggestive of fibromuscular dysplasia. The left renal artery also exhibited short-segment web-like stenosis (70% to 80%) in the mid-segment with a significant gradient across it (Fig. 1). Angioplasty of the stenotic segment was performed using an angioplasty balloon at a pressure of 10 atmospheres with good results (Fig. 2). After angioplasty, the patient's blood pressure normalized and she was discharged without any antihypertensive medications. At the 6-month follow-up, her blood pressure remained normal and she required no antihypertensive medications.

Fibromuscular dysplasia is a noninflammatory, nonatherosclerotic vascular disease that commonly involves the renal and internal carotid arteries; however, it can involve any arterial bed. Renal fibromuscular dysplasia usually affects females from 15 to 50 years of age and accounts for around 10% of cases of renal artery stenosis. Renal fibromuscular dysplasia is classified based on the predominant arterial layer involved: intima, media, or adventitia. Involvement of the media is further subdivided into medial, perimedial, and hyperplastic medial fibromuscular dysplasia. The three most common and classically described subtypes include medial (70% of cases), perimedial (15% to 25%), and intimal fibrodysplasias (1% to 2%). The classical angiographic "string of beads" appearance is seen in medial and perimedial fibromuscular dysplasias. It is characterized by alternating stenoses and aneurysms and frequently involves the bilateral renal arteries.

The most accurate method for diagnosis of fibromuscular dysplasia remains catheter-based angiography.