Korean J Intern Med > Volume 37(5); 2022 > Article |
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Parameter | Normal controls | IPF | NSIP | HP | Sarcoidosis |
---|---|---|---|---|---|
No. of subjects | 33 | 87 | 22 | 19 | 10 |
Age, yr | 55 (35 to 72) | 63.8 (32 to 86)a | 60.1 (39 to 70) | 51.3 (28 to 70) | 43.3 (28 to 69) |
Sex, male/female | 20/13 | 54/33 | 9/13 | 10/9 | 6/4 |
Smoking, CS/ES/NS | 2/1/30 | 38/29/20 | 2/5/12 | 3/2/13 | 3/2/5 |
FVC, % pred. | 106.1 (87.0 to 119) | 75.0 (63.7 to 83.0)a | 78.0 (66.0 to 91.8)a | 64.5 (57.0 to 82.5)a | 77.0 (65.0 to 86.0)a |
FEV1, % pred. | 102.1 (88.2 to 117) | 89.0 (77.5 to 100.5)a | 85.0 (73.8 to 101.3)a | 74.5 (64.3 to 92.0)a | 85.0 (64.0 to 101.0)a |
DLCO, % pred. | NA | 64.0 (38.5 to 72.5)a | 76.0 (59.0 to 92.0)a | 67.0 (55.0 to 90.0)a | 75.5 (57.8 to 84.5)a |
dFVC, %/yr | NA | −7.0 (−16.5 to 0.0) | NA | NA | NA |
dDLCO, %/yr | NA | −13 (−30 to 0.0) | −5 (−20.5 to 0.0) | NA | NA |
Follow-up duration, yr | NA | 4.1 (2.1 to 6.3) | ND | ND | ND |
BAL total cell count, 104/mL | 3.42 ± 0.96 | 5.61 ± 3.71a | 6.09 ± 2.74a | 6.12 ± 3.79a | 4.31 ± 2.92a |
Macrophages, 104/mL | 3.25 ± 0.93 | 3.43 ± 2.24a | 3.16 ± 1.89a | 3.19 ± 2.00a | 3.71 ± 2.76a |
Neutrophils, 104/mL | 0.08 ± 0.07 | 1.66 ± 2.30a | 2.44 ± 2.23a | 2.70 ± 2.89a | 0.37 ± 0.40a |
Eosinophils, 104/mL | 0.02 ± 0.03 | 0.29 ± 1.10a | 0.17 ± 0.27a | 0.17 ± 0.21a | 0.01 ± 0.01a |
Lymphocytes, 104/mL | 0.07 ± 0.06 | 0.23 ± 0.25a | 0.32 ± 0.29a | 0.41 ± 0.43a | 0.22 ± 0.18a |
Values are presented as median (interquartile range) or mean ± standard error of the mean. The differences among the normal control, IPF, NSIP, HP, and sarcoidosis groups were analyzed by Kruskal-Wallis analysis of variance (ANOVA) with a post hoc Mann-Whitney U test. The bronchoalveolar lavage fluid (BALF) cells’ differences among the five groups were analyzed by one-way ANOVA with the Tukey honestly significant difference post hoc test.
IPF, idiopathic pulmonary fibrosis; NSIP, nonspecific interstitial pneumonia; HP, hypersensitivity pneumonitis; CS, current-smoker; ES, ex-smoker; NS, never-smoker; FVC, forced vital capacity; FEV1, forced expiratory volume in 1 second; DLCO, diffusing capacity of the lung for carbon monoxide; NA, not applicable; dFVC, %/yr, annual decline rate of forced vital capacity; dDLCO, %/yr, annual rate of diffusing capacity of the lung for carbon monoxide; ND, not determined; BAL, bronchoalveolar lavage.
G-CSF, granulocyte colony-stimulating factor; BMI, body mass index; CS, current smoker; ES, ex-smoker; NS, never smoker; FVC, forced vital capacity; FEV1, forced expiratory volume in 1 second; DLCO, diffusing capacity of the lung for carbon monoxide; dFVC, %/yr, annual decline rate of forced vital capacity; dDLCO, %/yr, annual rate of diffusing capacity of the lung for carbon monoxide; BAL, bronchoalveolar lavage.