Despite the lack of malignant potential, mounting evidence suggests that a simple renal cyst is in fact not simple. A cross-sectional analysis of 872 1:1-matched patients from a single center in Korea showed that the presence of a cyst is clearly associated with hypertension (HTN) and that the number of cysts as well as their size are risk factors for HTN [4]. Another study, based on cross-analyses of 14,995 patients, found that simple renal cysts are associated with prehypertension as well as HTN [5] and that two or more simple renal cysts and cysts ≥ 2 cm are important determinants of prehypertension and HTN in adults. As HTN is a major risk factor for the development and progression of chronic kidney disease, the association between simple renal cysts and kidney dysfunction has been suggested, although not without debate [6]. The association of simple renal cysts and elevated serum creatinine was previously determined in a cross-sectional analysis of the general population [1], while in an analysis of 561 hospitalized individuals the presence of renal cysts, regardless of their number, was shown to be associated with reduced estimated creatinine clearance [7]. Taken together, the evidence so far strongly indicates an association of simple renal cysts with functional damage to the renal parenchyma. Consequently, whether simple renal cysts are also related to renal events that precede a reduced glomerular filtration rate, such as albuminuria, merits consideration.

In this issue of the Korean Journal of Internal Medicine, Boo et al. [3] report the results of their comprehensive evaluation of the association of simple renal cysts with hematuria and albuminuria in young adults (age < 40 years). Among 5,838 patients who underwent a comprehensive medical examination and were generally healthy, simple renal cysts were detected in 276 (cyst group). The prevalence of hematuria in the control versus the cyst group did not significantly differ (4.9% vs. 6.5%, p = 0.243), whereas the prevalence of albuminuria was significantly higher in the cyst than in the control group (11.3% vs. 4.5%, p < 0.001). The number of cysts (single vs. multiple) did not affect the prevalence of albuminuria (12.0% vs. 7.1%, p = 0.363). Multivariate regression analysis revealed an independent association of simple renal cysts with albuminuria (adjusted odds ratio, 2.307; 95% confidence interval, 1.512 to 3.519; p < 0.001). Support for this finding was obtained in a 1:2 propensity score matching analysis, in which the variables were age, sex, body mass index, systolic blood pressure, HTN, diabetes mellitus, estimated glomerular filtration rate, history of smoking, and serum uric acid level. Logistic regression analyses of albuminuria in matched cohorts robustly showed that simple renal cysts are associated with albuminuria (adjusted odds ratio, 1.858; 95% confidence interval, 1.112 to 3.107; p = 0.0182). Thus, the current study by Boo et al. [3] highlights the potential clinical significance of simple renal cysts. Although it is unclear whether a simple renal cyst is a cause or consequence of kidney damage, the study justifies the close monitoring of patients with simple renal cysts, especially adults < 40 years, for the development of albuminuria. Additional prospective studies investigating the association of renal cysts with albuminuria are warranted.

A limitation of the study of Boo et al. [3] is that most patients were in their late 30s, such that support for the clinical significance of simple renal cysts in individuals < 30 years of age was less substantial, as also noted by the authors. In addition, because the authors chose to exclude adults ≥ 40 years age, the clinical impact of simple renal cysts in older patients and in the elderly remains to be determined.

In summary, the study of Boo et al. [3] demonstrates the association of simple renal cysts with albuminuria in young adults and thus the clinical significance of these benign lesions. Additional prospective studies of the casual relation between renal cysts and albuminuria are needed.