| Effect of tegoprazan on temporal variability of platelet reactivity in patients treated with clopidogrel after coronary stenting |
Oh-Hyun Lee, Ji Woong Roh, Yongcheol Kim
, Eui Im, and Deok-Kyu Cho |
| Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine and Cardiovascular Center, Yongin Severance Hospital, Yongin, Korea |
Corresponding Author:
Yongcheol Kim , Tel: +82-31-5189-8967, Fax: +82-31-5189-8567, Email: yongcheol@yuhs.ac
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Received: November 22, 2024; Revised: January 15, 2025; Accepted: February 7, 2025. |
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| Abstract |
Background/Aims: Data on the interactions between clopidogrel and tegoprazan are limited. We compared the effects of tegoprazan and proton-pump inhibitors (PPIs) on platelet reactivity.
Methods: Using database data from March 2020 to January 2023, we retrospectively evaluated 262 patients who were taking either tegoprazan (n = 107) or PPIs (n = 155) combined with dual antiplatelet therapy, including aspirin and clopidogrel, after percutaneous coronary intervention. Platelet reactivity was assessed using VerifyNow P2Y12 assays.
Results: Platelet reaction unit (PRU) values at 3 (157 ± 8 vs. 162 ± 6, p = 0.659), 6 (167 ± 9 vs. 158 ± 7, p = 0.370), and 12 months (155 ± 10 vs. 164 ± 7, p = 0.448) were similar between groups. The prevalence of high on-treatment platelet reactivity, defined as ≥ 253 PRU, was also similar between the groups at 3 (10.3% vs. 10.2%, p = 0.976), 6 (7.0% vs. 8.2%, p = 1.000), and 12 months (4.3% vs. 9.0%, p = 0.503).
Conclusions: There was no significant difference in platelet reactivity between the tegoprazan and PPI groups in patients undergoing PCI and receiving dual antiplatelet therapy with clopidogrel. |
| Keywords:
Blood platelets ; Clopidogrel ; Platelet function tests ; Potassium-competitive acid blocker ; Proton pump inhibitors |
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