Stumbling across transthyretin amyloid cardiomyopathy during diagnostic work-up for stomach cancer

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Korean J Intern Med. 2023;38(2):273-274

Publication date (electronic) : 2022 November 2

doi : https://doi.org/10.3904/kjim.2022.280

Hyun-Ki Lee ¹^,^*, Yun-Seok Choi ¹^,^*, Eun Ji Han ², Yeoun Eun Sung ³, Jong-Chan Youn ¹

¹Division of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, Catholic Research Institute for Intractable Cardiovascular Disease, College of Medicine, The Catholic University of Korea, Seoul, Korea

²Division of Nuclear Medicine, Department of Radiology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

³Department of Hospital Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

Correspondence to Jong-Chan Youn, M.D., Tel: +82-2-2258-6145, Fax: +82-2-591-1506, E-mail: jong.chan.youn@gmail.com, https://orcid.org/0000-0003-0998-503X

These authors contributed equally to this work.

Received 2022 September 2; Revised 2022 October 5; Accepted 2022 October 24.

A 91-year-old socially active and independently ambulatory man was diagnosed with stomach cancer, pathologically confirmed as adenocarcinoma on biopsy. During cancer staging work up, ^99mTc-hydroxymethylene diphosphonate bone scintigraphy showed prominent radiotracer uptake in the heart (Fig. 1A). Electrocardiogram showed sinus bradycardia and low voltage in frontal lead (Fig. 1B). Echocardiography showed hypertrophy in the left ventricle (LV) with highly reflective myocardium and impaired relaxation type of diastolic dysfunction (average E/e′ ratio, 15.3) with enlarged left atrium (Supplementary Videos 1 and 2). Speckle tracking imaging showed an ‘apical sparing’ pattern on the bull’s eye plot of global longitudinal strain (Fig. 1C). Cardiac magnetic resonance imaging revealed septal LV hypertrophy, late gadolinium enhancement base-apex gradient, pericardial effusion, and pleural effusion (Fig. 1D). ^99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scan (Fig. 1E) and single-photon emission computed tomography (Fig. 1F) showed intense myocardial uptake suggestive of transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM). Endomyocardial biopsy showed pericellular interstitial deposition of amorphous and pale pink material (Fig. 1G), positive birefringence on Congo red staining (Fig. 1H) and positive TTR immunohistochemical staining (Fig. 1I). AL amyloid cardiomyopathy was ruled out based on serum free light chain quantification and serum, urine immunofixation electrophoresis. Genetic testing for TTR showed no mutation. On multidisciplinary discussion with the patient and family members, we decided to perform stomach cancer surgery because his functional capacity has been well preserved. After curative gastrectomy (Supplementary Fig. 1), the patient has been doing well for more than a year with tafamidis treatment for ATTR-CM. As ATTR-CM is more and more accidentally found in bone scintigraphy during cancer work up, further investigation for optimal treatment strategy in these patients are required.

Figure 1

(A) ^99mTc-hydroxymethylene diphosphonate bone scintigraphy showed prominent radiotracer uptake in the heart without any evidence of bone metastasis. (B) Electrocardiogram showed sinus bradycardia and low voltage in frontal lead. (C) Speckle tracking imaging showed an ‘apical sparing’ or a ‘cherry-on-top’ pattern on the bull’s eye plot of global longitudinal strain. (D) Cardiac magnetic resonance imaging revealed late gadolinium enhancement (red arrows) with base-apex gradient, pericardial effusion, and pleural effusion. (E) ^99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid oblique view and (F) single-photon emission computed tomography showed intense myocardial uptake suggestive of transthyretin amyloid cardiomyopathy. (G) Endomyocardial biopsy showed pericellular and nodular interstitial deposition of amorphous and pale pink material (H&E, ×100), (H) positive birefringence on Congo red staining (×100) and (I) positive transthyretin immunohistochemical staining (×200).

Supplementary Information

Supplementary Video 1

The parasternal long axis view of echocardiogram.

Supplementary Video 2

The apical four chamber view of echocardiogram.

Acknowledgments

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT (NRF-2021R1F1A1063430, NRF-2021R1G1A1007523) and by the Catholic Medical Center Research Foundation (2022). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Notes

No potential conflict of interest relevant to this article was reported.

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