A 39-year-old woman was referred to our hospital for invasive cervical cancer. On initial physical examination, inguinal lymph nodes, but not supraclavicular lymph nodes, were palpable. Positron emission tomography revealed multiple bone metastasis with hypermetabolic lymph nodes in the abdominal and pelvic cavity, left supraclavicular fossa, and a mild hypermetabolic nodular lesion in the left thyroid (Fig. 1A). Gun biopsy was performed for the left supraclavicular lymph node. Ultrasonography indicated the left thyroid nodule was a 1 cm sized hypoechoic lesion with inner calcification (Fig. 1B). Papillary thyroid carcinoma was diagnosed with fine needle aspiration (Fig. 1C). A lymph node specimen revealed synchronous metastasis from a double primary origin (Fig. 2A, ×40). One metastatic lesion (Fig. 2B, blue square, ×100) showed papillary growth and was positive for thyroglobulin immunohistochemical stain (Fig. 2C, ×100), consistent with thyroid carcinoma. Another metastatic lesion (Fig. 2D, yellow square, ×100) was negative for thyroglobulin (Fig. 2E, ×100). Immunohistochemical staining was positive for p16 (Fig. 2F, ×100) and p63 (Fig. 2G, ×100), verifying metastatic squamous cell carcinoma. Final diagnosis was advanced cervical cancer (stage IVb), and she received palliative chemotherapy. For thyroid cancer, low dose thyroxine was given for 3 months after confirming normal thyroid function and lost to follow-up.
The presence of double primary tumors is extremely rare. This is, to our knowledge, the first report of synchronous metastatic tumors in a single lymph node. The left supraclavicular lymph node, also known as Virchow’s node, is located in the confluence of lymphatic drainage from abdominal and pelvic cavities. Metastases from the gastrointestinal tract are occasionally present (5% to 8% for cervical cancer). Head and neck, lung, and breast cancers may also metastasize to the supraclavicular lymph nodes with no difference in incidence reported between left and right nodes. Most supraclavicular lymph node metastasis is related to a poor prognosis. For treatment plan development, life expectancies related to the primary malignancies should consider the patients’ condition.
No potential conflict of interest relevant to this article was reported.
Figures
(A) Positron-emission and computed tomography scans revealed multiple bone metastasis including pelvic bone, sacrum, a nd lumba r spine. Multiple conglomerated lymph nodes in the abdominal and pelvic cavity (yellow arrow) and left supraclavicular fossa (green arrow) were also hypermetabolic with mild hypermetabolic nodular lesion in the left thyroid (blue arrow). (B) The 1 cm left thyroid nodule was a well demarcated hypoechoic lesion with inner calcification on neck ultrasonography. (C) Cytology specimen revealed papillary thyroid carcinoma (May Grumwald Giemsa, ×400). Yellow arrow indicates pseudoinclusion body in the nucleus.
(A) Lymph node specimen presents two metastatic lesions marked with blue and yellow squares (H&E, ×40). One metastatic lesion (blue square) showed papillary growth (B, H&E, ×100) and was positive for thyroglobulin immunohistochemical stain (C, ×100). Another metastatic lesion (yellow square) showed squamous cell carcinoma feature (D, H&E, ×100) and was negative for thyroglobulin (E, ×100). Immunohistochemical staining verified metastatic squamous cell carcinoma from uterine cervix, which was positive for p16 (F, A ×100) and p63 (G, ×100).