KJIM :: Korean Journal of Internal Medicine

Scutellarin Alleviates Ovalbumin-Induced Airway Remodeling in Mice and TGF-β-Induced Pro-fibrotic Phenotype in Human Bronchial Epithelial Cells via MAPK and Smad2/3 Signaling Pathways

Minfang Li, Dan Jia, Jinshuai Li, Yaqing Li, Yaqiong Wang, Yuting Wang, Wei Xie, Sheng Chen

Diosmetin as a promising natural therapeutic agent: In vivo, in vitro mechanisms, and clinical studies

Zihao Sun, Kai Liu, Chuipeng Liang, Lin Wen, Jijiao Wu, Xiaolian Liu, Xiaofang Li

Phytotherapy Research.2024; 38(7): 3660. CrossRef

Mitigation of allergic asthma in mice: A compound mixture comprising luteolin, arbutin, and marmesin from Gerbera Piloselloides Herba by suppression of PI3K/Akt pathway

Chunhua Liu, Yu He, Kun Zhou, Hong Wang, Meng Zhou, Jia Sun, Yuan Lu, Yong Huang, Yonglin Wang, Ting Liu, Yongjun Li

Eupatilin Suppresses OVA-Induced Asthma by Inhibiting NF-κB and MAPK and Activating Nrf2 Signaling Pathways in Mice

Donghui Bai, Tianxiao Sun, Fang Lu, Yancheng Shen, Yan Zhang, Bo Zhang, Guangli Yu, Haihua Li, Jiejie Hao

International Journal of Molecular Sciences.2022; 23(3): 1582. CrossRef

Abundant TNF-LIGHT expression in the airways of patients with asthma with persistent airflow limitation: Association with nitrative and inflammatory profiles

Tsunahiko Hirano, Kazuto Matsunaga, Keiji Oishi, Keiko Doi, Misa Harada, Junki Suizu, Keita Murakawa, Ayumi Chikumoto, Yuichi Ohteru, Kazuki Matsuda, Sho Uehara, Kazuki Hamada, Shuichiro Ohata, Yoriyuki Murata, Yoshikazu Yamaji, Maki Asami-Noyama, Nobutak

Respiratory Investigation.2021; 59(5): 651. CrossRef

Lipoxin A4 inhibits ovalbumin-induced airway inflammation and airway remodeling in a mouse model of asthma

Chemico-Biological Interactions.2021; 349: 109660. CrossRef

Bixin protects mice against bronchial asthma though modulating PI3K/Akt pathway

Yingjie Zhu, Dong Sun, Han Liu, Linzi Sun, Jing Jie, Jingjing Luo, Liping Peng, Lei Song

International Immunopharmacology.2021; 101: 108266. CrossRef

Type 2-High Severe Asthma with and without Bronchiectasis: A Prospective Observational Multicentre Study

Claudia Crimi, Raffaele Campisi, Santi Nolasco, Sebastian Ferri, Giulia Cacopardo, Pietro Impellizzeri, Maria Provvidenza Pistorio, Evelina Fagone, Corrado Pelaia, Enrico Heffler, Nunzio Crimi

Journal of Asthma and Allergy.2021; Volume 14: 1441. CrossRef

Emodin ameliorates ovalbumin-induced airway remodeling in mice by suppressing airway smooth muscle cells proliferation

Yuanyuan Liu, Xin Li, Chao He, Ran Chen, Li Wei, Ling Meng, Caiqing Zhang

International Immunopharmacology.2020; 88: 106855. CrossRef

Alpinetin prevents inflammatory responses in OVA-induced allergic asthma through modulating PI3K/AKT/NF-κB and HO-1 signaling pathways in mice

Di Wu, Shuangqiu Li, Xiao Liu, Jingnan Xu, Aimin Jiang, Yong Zhang, Ziyi Liu, Jingjing Wang, Ershun Zhou, Zhengkai Wei, Zhengtao Yang, Changmin Guo

International Immunopharmacology.2020; 89: 107073. CrossRef

Huangqi–Fangfeng protects against allergic airway remodeling through inhibiting epithelial–mesenchymal transition process in mice via regulating epithelial derived TGF-β1

Lu Yao, Siqi Wang, Pan Wei, Kaifan Bao, Weiyuan Yuan, Xiaotong Wang, Jie Zheng, Min Hong

Orchestration of epithelial-derived cytokines and innate immune cells in allergic airway inflammation

Cytokine & Growth Factor Reviews.2018; 39: 19. CrossRef

Eosinophil‐derived exosomes contribute to asthma remodelling by activating structural lung cells

J. A. Cañas, B. Sastre, J. M. Rodrigo‐Muñoz, M. Fernández‐Nieto, P. Barranco, S. Quirce, J. Sastre, V. del Pozo

Clinical & Experimental Allergy.2018; 48(9): 1173. CrossRef

New targets for resolution of airway remodeling in obstructive lung diseases

Ajay P. Nayak, Deepak A. Deshpande, Raymond B. Penn

Bronchial thermoplasty: a non‐pharmacological approach

The Clinical Respiratory Journal.2017; 11(1): 13. CrossRef

Interplay of extracellular matrix and leukocytes in lung inflammation

Thomas N. Wight, Charles W. Frevert, Jason S. Debley, Stephen R. Reeves, William C. Parks, Steven F. Ziegler

Combined treatment with zingerone and its novel derivative synergistically inhibits TGF-β1 induced epithelial-mesenchymal transition, migration and invasion of human hepatocellular carcinoma cells

Young-Joo Kim, Youngsic Jeon, Taejung Kim, Won-Chul Lim, Jungyeob Ham, Young Nyun Park, Tae-Jin Kim, Hyeonseok Ko

Bioorganic & Medicinal Chemistry Letters.2017; 27(4): 1081. CrossRef

Oral administration of Clostridium butyricum CGMCC0313‐1 reduces ovalbumin‐induced allergic airway inflammation in mice

Zhang Juan, Shi Zhao‐Ling, Zeng Ming‐Hua, Wei Chun, Wu Hai‐Xia, Liu Meng‐Yun, Huang Jian‐Qiong, Zheng Yue‐Jie, Sun Xin

Bacillus Calmette-Guerin alleviates airway inflammation and remodeling by preventing TGF-β1induced epithelial–mesenchymal transition

Xinrui Tian, Xinli Tian, Rujie Huo, Qin Chang, Guoping Zheng, Yan Du, Yan Chen, Bo Niu

Human Vaccines & Immunotherapeutics.2017; 13(8): 1758. CrossRef

The Toxicological Mechanisms of Environmental Soot (Black Carbon) and Carbon Black: Focus on Oxidative Stress and Inflammatory Pathways

MicroRNA-145 down-regulates mucin 5AC to alleviate airway remodeling and targets EGFR to inhibit cytokine expression

Zhe Cheng, Ling-Ling Dai, Xi Wang, Liu-Qun Jia, Xiao-Gang Jing, Peng-Fei Li, Meng Liu, Huan Wang, Lin An

Epigallocatechin-3-gallate inhibits inflammation and epithelial‑mesenchymal transition through the PI3K/AKT pathway via upregulation of PTEN in asthma

International Journal of Molecular Medicine.2017;[Epub] CrossRef

Diosmetin prevents TGF-β1-induced epithelial-mesenchymal transition via ROS/MAPK signaling pathways

Ai Ge, Yuan Ma, Ya-Nan Liu, Ye-Shan Li, Hao Gu, Jia-Xiang Zhang, Qin-Xue Wang, Xiao-Ning Zeng, Mao Huang

Dietary flavanones and citrus fruits influence cytokines and thyroid transcription factor-1 in an HDM-induced chronic asthma murine model

Ensiyeh Seyedrezazadeh, Amin Sabri, Abolfazl Barzegari, Saeed Kolahian, Amir-Ali Shahbazfar, Khalil Ansarin, Mohammadreza Vafa, Ebrahim Sakhinia

Journal of Functional Foods.2016; 26: 709. CrossRef

Inundation of asthma target research: Untangling asthma riddles

Pulmonary Pharmacology & Therapeutics.2016; 41: 60. CrossRef

Functions of thymic stromal lymphopoietin in non-allergic diseases

Guoqing Ying, Yanlu Zhang, Guoqiang Tang, Shuqing Chen

Fibroblast-myofibroblast transition is differentially regulated by bronchial epithelial cells from asthmatic children

Stephen R Reeves, Tessa Kolstad, Tin-Yu Lien, Sarah Herrington-Shaner, Jason S Debley

Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology

Madalina V. Nastase, Renato V. Iozzo, Liliana Schaefer

Biochimica et Biophysica Acta (BBA) - General Subjects.2014; 1840(8): 2460. CrossRef

Biomolecular markers in assessment and treatment of asthma

Farnaz Fatemi, Esmaeil Sadroddiny, Azam Gheibi, Taiebeh Mohammadi Farsani, Gholam Ali Kardar

Montelukast suppresses epithelial to mesenchymal transition of bronchial epithelial cells induced by eosinophils

Koa Hosoki, Keigo Kainuma, Masaaki Toda, Etsuko Harada, Ayshwarya-Lakshmi Chelakkot-Govindalayathila, Ziaurahman Roeen, Mizuho Nagao, Corina N. D’Alessandro-Gabazza, Takao Fujisawa, Esteban C. Gabazza

Biochemical and Biophysical Research Communications.2014; 449(3): 351. CrossRef

Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma

Seil Sagar, Mary E Morgan, Si Chen, Arjan P Vos, Johan Garssen, Jeroen van Bergenhenegouwen, Louis Boon, Niki A Georgiou, Aletta D Kraneveld, Gert Folkerts

FIZZ1 promotes airway remodeling through the PI3K/Akt signaling pathway in asthma

JUNFEI WANG, FEI LI, MENGMENG YANG, JINXIANG WU, JIPING ZHAO, WENBIN GONG, WEN LIU, WENXIANG BI, LIANG DONG

Experimental and Therapeutic Medicine.2014; 7(5): 1265. CrossRef

Comparison of TNF antagonism by etanercept and dexamethasone on airway epithelium and remodeling in an experimental model of asthma

Ozge Yilmaz, Meral Karaman, H. Alper Bagriyanik, Fatih Firinci, Muge Kiray, Ahmet Turkeli, Ozkan Karaman, Hasan Yuksel

International Immunopharmacology.2013; 17(3): 768. CrossRef

AVE 0991, a non‐peptide mimic of angiotensin‐(1–7) effects, attenuates pulmonary remodelling in a model of chronic asthma

M G Rodrigues‐Machado, G S Magalhães, J A Cardoso, L M Kangussu, A Murari, M V Caliari, M L Oliveira, D C Cara, M L M Noviello, F D Marques, J M Pereira, R Q Lautner, R A S Santos, M J Campagnole‐Santos

British Journal of Pharmacology.2013; 170(4): 835. CrossRef

Immune response to Streptococcus pneumoniae in asthma patients: comparison between stable situation and exacerbation

C Otero, R D Paz, N Galassi, L Bezrodnik, M R Finiasz, S Fink

Clinical and Experimental Immunology.2013; 173(1): 92. CrossRef

Predicting adverse drug reaction profiles by integrating protein interaction networks with drug structures

Eosinophils Promote Epithelial to Mesenchymal Transition of Bronchial Epithelial Cells

Atsushi Yasukawa, Koa Hosoki, Masaaki Toda, Yasushi Miyake, Yuki Matsushima, Takahiro Matsumoto, Daniel Boveda-Ruiz, Paloma Gil-Bernabe, Mizuho Nagao, Mayumi Sugimoto, Yukiko Hiraguchi, Reiko Tokuda, Masahiro Naito, Takehiro Takagi, Corina N. D'Alessandro

trans-Caryophyllene, a Natural Sesquiterpene, Causes Tracheal Smooth Muscle Relaxation through Blockade of Voltage-Dependent Ca2+ Channels

Leidiane Pinho-da-Silva, Paula Virgínia Mendes-Maia, Taylena Maria do Nascimento Garcia Teófilo, Roseli Barbosa, Vania Marilande Ceccatto, Andrelina Noronha Coelho-de-Souza, Jader Santos Cruz, José Henrique Leal-Cardoso