Klotho and the Aging Process
Makoto Kuro-o
Korean J Intern Med. 2011;26(2):113-122.   Published online 2011 Jun 1     DOI: https://doi.org/10.3904/kjim.2011.26.2.113
Citations to this article as recorded by Crossref logo
Klotho-derived peptide KP1 ameliorates SARS-CoV-2-associated acute kidney injury
Jie Xu, Enqing Lin, Xue Hong, Li Li, Jun Gu, Jinghong Zhao, Youhua Liu
Frontiers in Pharmacology.2024;[Epub]     CrossRef
Serum klotho levels and mortality patterns in frail individuals: unraveling the u-shaped association
Huanhuan Luo, Zitian Zheng, Huixiu Hu, Chao Sun
Aging Clinical and Experimental Research.2024;[Epub]     CrossRef
Hypermethylation of Klotho and Peroxisome Proliferator-Activated Receptor γ Concomitant with Overexpression of DNA Methyltransferase 1 in Adenomyosis
Jiao Fan, Xishi Liu, Sun-Wei Guo
Reproductive Sciences.2024;[Epub]     CrossRef
Apolipoproteine and KLOTHO Gene Variants Do Not Affect the Penetrance of Fragile X-Associated Tremor/Ataxia Syndrome
Tri Indah Winarni, Ye Hyun Hwang, Susan M. Rivera, David Hessl, Blythe P. Durbin-Johnson, Agustini Utari, Randi Hagerman, Flora Tassone
International Journal of Molecular Sciences.2024; 25(15): 8103.     CrossRef
Gender-specific association between circulating serum Klotho and metabolic components in adults
Zhenzhen Wang, Hang Zhang, Guixia Zheng, Zheng Wang, Lei Shi
BMC Endocrine Disorders.2024;[Epub]     CrossRef
Effect of cigarette smoking on serum methylarginine and α-klotho levels
Mustafa Onmaz, Nur Demirbas, Duygu Eryavuz Onmaz, Ruhusen Kutlu, Ali Unlu
Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(3): 602.     CrossRef
Impaired NRF2 Inhibits Recovery from Ischemic Reperfusion Injury in the Aging Kidney
Min Jee Jo, Ji Eun Kim, So Yon Bae, Eunjung Cho, Shin Young Ahn, Young Joo Kwon, Gang-Jee Ko
Antioxidants.2023; 12(7): 1440.     CrossRef
Klotho inhibits IGF1R/PI3K/AKT signalling pathway and protects the heart from oxidative stress during ischemia/reperfusion injury
Agnieszka Olejnik, Anna Radajewska, Anna Krzywonos-Zawadzka, Iwona Bil-Lula
Scientific Reports.2023;[Epub]     CrossRef
The Role of the FGF19 Family in the Pathogenesis of Gestational Diabetes: A Narrative Review
Agata Sadowska, Elżbieta Poniedziałek-Czajkowska, Radzisław Mierzyński
International Journal of Molecular Sciences.2023; 24(24): 17298.     CrossRef
Low muscle mass and early hospital readmission post-kidney transplantation
Limy Wong, Annette B. Kent, Darren Lee, Matthew A. Roberts, Lawrence P. McMahon
International Urology and Nephrology.2022; 54(8): 1977.     CrossRef
The association between serum soluble klotho levels and abdominal aorta calcification in older adults
Carlos Heriberto Orces
Aging Clinical and Experimental Research.2022; 34(6): 1447.     CrossRef
Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer’s Disease: A Review
Tsz Fung, Ashok Iyaswamy, Sravan Sreenivasmurthy, Senthilkumar Krishnamoorthi, Xin-Jie Guan, Zhou Zhu, Cheng-Fu Su, Jia Liu, Yuxuan Kan, Yuan Zhang, Hoi Wong, Min Li
Biomedicines.2022; 10(3): 705.     CrossRef
A comprehensive review of cycloastragenol: Biological activity, mechanism of action and structural modifications
Mengting He, Ke Wang, Haojie Che, Huifang Wang, Kan Yang, Guiming Zhang, Jingchun Yao, Jinxin Wang
European Journal of Medicinal Chemistry Reports.2022; 5: 100060.     CrossRef
The association between metabolic syndrome and the anti-aging humoral factor klotho in middle-aged and older adults
Carlos H. Orces
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2022; 16(6): 102522.     CrossRef
Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models
Nurcan Inci, Dilanur Kamali, Erdogan Oguzhan Akyildiz, Eda Tahir Turanli, Perinur Bozaykut
Frontiers in Aging.2022;[Epub]     CrossRef
Retinoic acid induces hyaluronic acid production through the klotho-mediated EGFR signaling pathway in human epidermal keratinocytes
Hyangtae Choi, Yonghee Lee, Won-seok Park, Beom Kim, Chang Lee
Archives of Biological Sciences.2022; 74(1): 91.     CrossRef
Association between testosterone and serum soluble α-klotho in U.S. males: a cross-sectional study
Zilong Zhang, Shi Qiu, Xinyi Huang, Kun Jin, Xianghong Zhou, Tianhai Lin, Xiaoli Zou, Qiuxiang Yang, Lu Yang, Qiang Wei
BMC Geriatrics.2022;[Epub]     CrossRef
The Association of Obesity and the Antiaging Humoral Factor Klotho in Middle-Aged and Older Adults
Carlos H. Orces, Benito Soto-Blanco
The Scientific World Journal.2022; 2022: 1.     CrossRef
Obesity, Diabetes Mellitus, and Vascular Impediment as Consequences of Excess Processed Food Consumption
Susmita Sinha, Mainul Haque
Cureus.2022;[Epub]     CrossRef
Cancer Cachexia and Dysregulated Phosphate Metabolism: Insights from Mutant p53 and Mutant Klotho Mouse Models
Ronald B. Brown
Metabolites.2022; 12(12): 1284.     CrossRef
Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice
Dingwen Jiang, Chang Liu, Ye Chen, Xuejiao Xing, Danmeng Zheng, Zhanpeng Guo, Sen Lin
International Journal of Sports Medicine.2021; 42(05): 464.     CrossRef
Soluble αKlotho downregulates Orai1-mediated store-operated Ca2+ entry via PI3K-dependent signaling
Ji-Hee Kim, Eun Young Park, Kyu-Hee Hwang, Kyu-Sang Park, Seong Jin Choi, Seung-Kuy Cha
Pflügers Archiv - European Journal of Physiology.2021; 473(4): 647.     CrossRef
Constitutive Expression of TERT Enhances β-Klotho Expression and Improves Age-Related Deterioration in Early Bovine Embryos
Lianguang Xu, Muhammad Idrees, Myeong-Don Joo, Tabinda Sidrat, Yiran Wei, Seok-Hwan Song, Kyeong-Lim Lee, Il-Keun Kong
International Journal of Molecular Sciences.2021; 22(10): 5327.     CrossRef
Effect of NAD+ boosting on kidney ischemia-reperfusion injury
Marya Morevati, Søren Egstrand, Anders Nordholm, Maria L. Mace, Claus B. Andersen, Rouzbeh Salmani, Klaus Olgaard, Ewa Lewin, Niels Olsen Saraiva Câmara
PLOS ONE.2021; 16(6): e0252554.     CrossRef
Klotho inhibits neuronal senescence in human brain organoids
Mohammed R. Shaker, Julio Aguado, Harman Kaur Chaggar, Ernst J. Wolvetang
npj Aging and Mechanisms of Disease.2021;[Epub]     CrossRef
Tacrolimus Decreases Cognitive Function by Impairing Hippocampal Synaptic Balance: a Possible Role of Klotho
Yoo Jin Shin, Sun Woo Lim, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Hong Lim Kim, Tae Ryong Riew, Mun Yong Lee, Chul Woo Yang
Molecular Neurobiology.2021; 58(11): 5954.     CrossRef
The Ability of Nutrition to Mitigate Epigenetic Drift: A Novel Look at Regulating Gene Expression
Raymond D. PALMER, Veronica PAPA, Mauro VACCAREZZA
Journal of Nutritional Science and Vitaminology.2021; 67(6): 359.     CrossRef
Efficacy of Gene Therapy to Restore Cognition in Alzheimer’s Disease: A Systematic Review
Desyrre V. Tedeschi, Anderson F da Cunha, Márcia R. Cominetti, Renata Valle Pedroso
Current Gene Therapy.2021; 21(3): 246.     CrossRef
Mechanistic target of rapamycin signaling in mouse models of accelerated aging
Jin Young Lee, Brian K Kennedy, Chen-Yu Liao, Dudley Lamming
The Journals of Gerontology: Series A.2020; 75(1): 64.     CrossRef
The Klotho Variant rs36217263 Is Associated With Poor Response to Cardioselective Beta‐Blocker Therapy Among Filipinos
Rody G. Sy, Jose B. Nevado, Elmer Jasper B. Llanes, Jose Donato A. Magno, Deborah Ignacia D. Ona, Felix Eduardo R. Punzalan, Paul Ferdinand M. Reganit, Lourdes Ella G. Santos, Richard Henry P. Tiongco, Jaime Alfonso M. Aherrera, Lauro L. Abrahan, Charlene
Clinical Pharmacology & Therapeutics.2020; 107(1): 221.     CrossRef
Z‐ligustilide: A review of its pharmacokinetics and pharmacology
Qingxuan Xie, Linlin Zhang, Long Xie, Yu Zheng, Kai Liu, Hailong Tang, Yanmei Liao, Xiaofang Li
Phytotherapy Research.2020; 34(8): 1966.     CrossRef
Klotho-HIV and Oxidative Stress: The Role of Klotho in Cardiovascular Disease Under HIV Infection—A Review
Alberto Alejandro Miranda Pérez, María Elena Gutiérrez Pérez, Arguiñe Ivonne Urraza Robledo, Dealmy Delgadillo Guzmán, Pablo Ruíz Flores, Francisco Carlos López Márquez
DNA and Cell Biology.2020; 39(9): 1478.     CrossRef
Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: a case-control study
Ernesto Martín-Núñez, Javier Donate-Correa, Carla Ferri, Ángel López-Castillo, Alejandro Delgado-Molinos, Carolina Hernández-Carballo, Nayra Pérez-Delgado, Sergio Rodríguez-Ramos, Purificación Cerro-López, Víctor G. Tagua, Carmen Mora-Fernández, Juan F. N
Aging.2020; 12(2): 1952.     CrossRef
Enhanced Klotho availability protects against cardiac dysfunction induced by uraemic cardiomyopathy by regulating Ca2+ handling
José Alberto Navarro‐García, Angélica Rueda, Tatiana Romero‐García, Jennifer Aceves‐Ripoll, Elena Rodríguez‐Sánchez, Laura González‐Lafuente, Carlos Zaragoza, María Fernández‐Velasco, Makoto Kuro‐o, Luis M. Ruilope, Gema Ruiz‐Hurtado
British Journal of Pharmacology.2020; 177(20): 4701.     CrossRef
Expression of Phosphatonin-Related Genes in Sheep, Dog and Horse Kidneys Using Quantitative Reverse Transcriptase PCR
Keren E. Dittmer, Rosemary W. Heathcott, Jonathan C. Marshall, Sara Azarpeykan
Animals.2020; 10(10): 1806.     CrossRef
Vitamin D Metabolism and Its Role in Mineral and Bone Disorders in Chronic Kidney Disease in Humans, Dogs and Cats
Fernanda C. Chacar, Márcia M. Kogika, Rafael V. A. Zafalon, Marcio A. Brunetto
Metabolites.2020; 10(12): 499.     CrossRef
Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies
Jie Xu, Lili Zhou, Youhua Liu
Frontiers in Pharmacology.2020;[Epub]     CrossRef
Calcitonin gene-related peptide inhibits the cardiac fibroblasts senescence in cardiac fibrosis via up-regulating klotho expression
Wen-Qun Li, Sheng-Lan Tan, Xiao-Hui Li, Tao-Li Sun, Dai Li, Jie Du, Shan-Shan Wei, Yuan-Jian Li, Bi-Kui Zhang
European Journal of Pharmacology.2019; 843: 96.     CrossRef
Rapid decline of kidney function in diabetic kidney disease is associated with high soluble Klotho levels
Flaviu Bob, Adalbert Schiller, Romulus Timar, Daniel Lighezan, Oana Schiller, Bogdan Timar, Cristiana Georgeta Bujor, Mircea Munteanu, Florica Gadalean, Adelina Mihaescu, Iulia Grosu, Andreea Hategan, Lazar Chisavu, Agneta-Maria Pusztai, Adrian Covic
Nefrología.2019; 39(3): 250.     CrossRef
Klotho Deficiency Accelerates Stem Cells Aging by Impairing Telomerase Activity
Mujib Ullah, Zhongjie Sun, Joshua M Hare
The Journals of Gerontology: Series A.2019; 74(9): 1396.     CrossRef
α-Klotho protein in neurodegenerative and mental diseases
T. A. Prokhorova, I. S. Boksha, O. K. Savushkina, E. B. Tereshkina, G. Sh. Burbaeva
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2019; 119(1): 80.     CrossRef
Adherence to the Mediterranean diet, dietary factors, and S-Klotho plasma levels in sedentary middle-aged adults
Lucas Jurado-Fasoli, Francisco J. Amaro-Gahete, Alejandro De-la-O, Borja Martinez-Tellez, Jonatan R. Ruiz, Ángel Gutiérrez, Manuel J. Castillo
Experimental Gerontology.2019; 119: 25.     CrossRef
Blood and urine biomarkers in chronic kidney disease: An update
Mohammad Zulkarnain Bidin, Anim Md Shah, J. Stanslas, Christopher Lim Thiam Seong
Clinica Chimica Acta.2019; 495: 239.     CrossRef
The interplay of Klotho with signaling pathway and microRNAs in cancers
Maryam Abolghasemi, Tooba Yousefi, Mahmood Maniati, Durdi Qujeq
Journal of Cellular Biochemistry.2019; 120(9): 14306.     CrossRef
Rapid decline of kidney function in diabetic kidney disease is associated with high soluble Klotho levels
Flaviu Bob, Adalbert Schiller, Romulus Timar, Daniel Lighezan, Oana Schiller, Bogdan Timar, Cristiana Georgeta Bujor, Mircea Munteanu, Florica Gadalean, Adelina Mihaescu, Iulia Grosu, Andreea Hategan, Lazar Chisavu, Agneta-Maria Pusztai, Adrian Covic
Nefrología (English Edition).2019; 39(3): 250.     CrossRef
Re: “Decreased Levels of Anti-Aging Klotho in Obstructive Sleep Apnea” by Pákó et al. (Rejuvenation Res 2019 [Epub ahead of print]; DOI: 10.1089/rej.2019.2183)
Priscila Farias Tempaku, Vania D'Almeida, Sergio Tufik
Rejuvenation Research.2019; 22(4): 364.     CrossRef
Role of Klotho in Chronic Calcineurin Inhibitor Nephropathy
Kang Luo, Sun Woo Lim, Yi Quan, Sheng Cui, Yoo Jin Shin, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang
Oxidative Medicine and Cellular Longevity.2019; 2019: 1.     CrossRef
Effect of Exercise Training and Aging on Klotho Signaling in the Heart
Behrouz Baghaiee, Maliheh Barzegari, Mohammad Hossein Sadeghi Zali, Mehdi Hakimi
Journal of Clinical Research in Paramedical Sciences.2019;[Epub]     CrossRef
Association of basal metabolic rate and fuel oxidation in basal conditions and during exercise, with plasma S-klotho: the FIT-AGEING study
Francisco J. Amaro-Gahete, Alejandro De-la-O, Lucas Jurado-Fasoli, Jonatan R. Ruiz, Manuel J. Castillo
Aging.2019; 11(15): 5319.     CrossRef
The relationship between serum FGF-23 concentration and insulin resistance, prediabetes and dyslipidemia in obese children and adolescents
Yesim Kutluturk, Aysehan Akinci, Ibrahim Halil Ozerol, Saim Yologlu
Journal of Pediatric Endocrinology and Metabolism.2019; 32(7): 707.     CrossRef
Klotho protects human monocytes from LPS-induced immune impairment associated with immunosenescent-like phenotype
Jennifer Mytych, Maria Romerowicz-Misielak, Marek Koziorowski
Molecular and Cellular Endocrinology.2018; 470: 1.     CrossRef
Circulating CD34+ and CD34+VEGFR2+ progenitor cells are associated with KLOTHO KL-VS polymorphism
Maria Skrzypkowska, Bartosz Słomiński, Monika Ryba-Stanisławowska, Piotr Gutknecht, Janusz Siebert
Microvascular Research.2018; 119: 1.     CrossRef
The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk
Eva-Maria Pastor-Arroyo, Nicole Gehring, Christiane Krudewig, Sarah Costantino, Carla Bettoni, Thomas Knöpfel, Sibylle Sabrautzki, Bettina Lorenz-Depiereux, Johanne Pastor, Tim M. Strom, Martin Hrabě de Angelis, Giovanni G. Camici, Francesco Paneni, Carst
Kidney International.2018; 94(1): 49.     CrossRef
Maintenance of Kidney Metabolic Homeostasis by PPAR Gamma
Patricia Corrales, Adriana Izquierdo-Lahuerta, Gema Medina-Gómez
International Journal of Molecular Sciences.2018; 19(7): 2063.     CrossRef
Association of circular Klotho and insulin-like growth factor 1 with cardiac hypertrophy indexes in athlete and non-athlete women following acute and chronic exercise
Sepideh Rahimi, Kamal Khademvatani, Mohammad Reza Zolfaghari
Biochemical and Biophysical Research Communications.2018; 505(2): 448.     CrossRef
Macrophages express βKlotho in skin lesions of psoriatic patients and the skin of imiquimod‐treated mice
Kozo Nakai, Reiji Haba, Yoshio Kushida, Yasuo Kubota
The Journal of Dermatology.2018; 45(12): 1475.     CrossRef
The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases
Agnieszka Olejnik, Aleksandra Franczak, Anna Krzywonos-Zawadzka, Marta Kałużna-Oleksy, Iwona Bil-Lula
BioMed Research International.2018; 2018: 1.     CrossRef
FGF23 Neutralizing Antibody Ameliorates Hypophosphatemia and Impaired FGF Receptor Signaling in Kidneys of HMWFGF2 Transgenic Mice
E. Du, L. Xiao, M.M. Hurley
Journal of Cellular Physiology.2017; 232(3): 610.     CrossRef
The SAMP8 mouse for investigating memory and the role of insulin in the brain
Elizabeth M. Rhea, William A. Banks
Experimental Gerontology.2017; 94: 64.     CrossRef
Association of Serum Phosphate Levels and Anemia in Critically Ill Surgical Patients
Tiffany M. N. Otero, Cecilia Canales, D. Dante Yeh, Emily A. Johnson, Tara M. Harrison, Donna Belcher, Sadeq A. Quraishi
Journal of Parenteral and Enteral Nutrition.2017; 41(6): 986.     CrossRef
Klotho ameliorates oxidized low density lipoprotein (ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K/Akt/eNOS pathways
Yansheng Yao, Yanbing Wang, Yibo Zhang, Chang Liu
Lipids in Health and Disease.2017;[Epub]     CrossRef
Targeted inhibition of Klotho binding to fibroblast growth factor 23 prevents hypophosphetemia
Muhammad Fakhar, Sajid Rashid
Journal of Molecular Graphics and Modelling.2017; 75: 9.     CrossRef
Vitamin D deficiency is associated with increased risk of bacterial infections after kidney transplantation
Young-Jae Park, Sang-Un Kim, Kyung-Hee Lee, Jong-Hak Lee, Eugene Kwon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Hyung-Kee Kim, Seung Huh, Chan-Duck Kim
The Korean Journal of Internal Medicine.2017; 32(3): 505.     CrossRef
Serum Klotho, vitamin D, and homocysteine in combination predict the outcomes of Chinese patients with multiple system atrophy
Yue Guo, Xiao‐Dong Zhuang, Wen‐Biao Xian, Ling‐Ling Wu, Ze‐Na Huang, Xun Hu, Xiang‐Song Zhang, Ling Chen, Xin‐Xue Liao
CNS Neuroscience & Therapeutics.2017; 23(8): 657.     CrossRef
Epigenetic suppression of the anti-aging geneKLOTHOin human prostate cancer cell lines
Minkyu Seo, Min Su Kim, Ara Jang, Hyun Joo Chung, Yoohun Noh, Do-Hee Kim, Jaehyouk Lee, Kisung Ko, Soon Chul Myung
Animal Cells and Systems.2017; 21(4): 223.     CrossRef
Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease
Xi Kuang, Hong-Jing Zhou, Amy H. Thorne, Xi-Nan Chen, Lin-Jiao Li, Jun-Rong Du
Frontiers in Aging Neuroscience.2017;[Epub]     CrossRef
WNT signaling – lung cancer is no exception
Judit Rapp, Luca Jaromi, Krisztian Kvell, Gyorgy Miskei, Judit E. Pongracz
Respiratory Research.2017;[Epub]     CrossRef
Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice
Haipeng Hui, Yufeng Zhai, Lihua Ao, Joseph C. Cleveland, Hongbin Liu, David A. Fullerton, Xianzhong Meng
Oncotarget.2017; 8(9): 15663.     CrossRef
Induction of anti-aging gene klotho with a small chemical compound that demethylates CpG islands
Dongju Jung, Yuechi Xu, Zhongjie Sun
Oncotarget.2017; 8(29): 46745.     CrossRef
Expression of klotho and β-catenin in esophageal squamous cell carcinoma, and their clinicopathological and prognostic significance
X. Tang, Z. Fan, Y. Wang, G. Ji, M. Wang, J. Lin, S. Huang
Diseases of the Esophagus.2016; 29(3): 207.     CrossRef
Klotho: a tumor suppressor and modulator of the Wnt/β-catenin pathway in human hepatocellular carcinoma
Xiaowei Tang, Yun Wang, Zhining Fan, Guozhong Ji, Min Wang, Jie Lin, Shu Huang, Stephen J Meltzer
Laboratory Investigation.2016; 96(2): 197.     CrossRef
Cognitive Changes in Chronic Kidney Disease and After Transplantation
Marit S. Van Sandwijk, Ineke J. M. Ten Berge, Charles B.L.M. Majoie, Matthan W.A. Caan, Leo M. J. De Sonneville, Willem A. Van Gool, Frederike J. Bemelman
Transplantation.2016; 100(4): 734.     CrossRef
Deficiency in the anti‐aging gene Klotho promotes aortic valve fibrosis through AMPK α‐mediated activation of RUNX 2
Jianglei Chen, Yi Lin, Zhongjie Sun
Aging Cell.2016; 15(5): 853.     CrossRef
Klotho Prevents NFκB Translocation and Protects Endothelial Cell From Senescence Induced by Uremia
Paula Buendía, Julia Carracedo, Sagrario Soriano, Juan Antonio Madueño, Alberto Ortiz, Alejandro Martín-Malo, Pedro Aljama, Rafael Ramírez
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences.2015; 70(10): 1198.     CrossRef
βKlotho expression is reduced in human non‐melanoma skin cancer
Kozo Nakai, Kozo Yoneda, Reiji Haba, Yoshio Kushida, Naomi Katsuki, Junko Moriue, Tetsuya Moriue, Ayako Koura, Ikumi Yokoi, Emiko Ishikawa, Shigeaki Inoue, Yasuo Kubota
International Journal of Dermatology.2015;[Epub]     CrossRef
FGF23 in Acute and Chronic Illness
Christian Schnedl, Astrid Fahrleitner-Pammer, Peter Pietschmann, Karin Amrein
Disease Markers.2015; 2015: 1.     CrossRef
Vitamin D and chronic kidney disease
Chang Seong Kim, Soo Wan Kim
The Korean Journal of Internal Medicine.2014; 29(4): 416.     CrossRef
The renin-angiotensin system and aging in the kidney
Hye Eun Yoon, Bum Soon Choi
The Korean Journal of Internal Medicine.2014; 29(3): 291.     CrossRef
Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model
Xi Kuang, Ya-Shu Chen, Liang-Fen Wang, Yong-Jie Li, Ke Liu, Meng-Xue Zhang, Ling-Jiao Li, Chu Chen, Qian He, Yu Wang, Jun-Rong Du
Neurobiology of Aging.2014; 35(1): 169.     CrossRef
Reduced Klotho is associated with the presence and severity of coronary artery disease
Juan F Navarro-González, Javier Donate-Correa, Mercedes Muros de Fuentes, Horacio Pérez-Hernández, Rafael Martínez-Sanz, Carmen Mora-Fernández
Heart.2014; 100(1): 34.     CrossRef
Two cases of nevus sebaceous accompanying secondary tumors with βKlotho expression
Kozo Nakai, Kozo Yoneda, Reiji Haba, Yoshio Kushida, Naomi Katsuki, Junko Moriue, Tetsuya Moriue, Emiko Ishikawa, Shigeaki Inoue, Yasuo Kubota
The Journal of Dermatology.2014; 41(2): 171.     CrossRef
Deranged epidermal differentiation in kl/kl mouse and the effects of βKlotho siRNA on the differentiation of HaCaT cells
Kozo Nakai, Kozo Yoneda, Reiji Haba, Yoshio Kushida, Naomi Katsuki, Tetsuya Moriue, Hiroaki Kosaka, Yasuo Kubota, Shigeaki Inoue
Experimental Dermatology.2013; 22(11): 772.     CrossRef
The mouse as a model organism in aging research: Usefulness, pitfalls and possibilities
Valerie Vanhooren, Claude Libert
Ageing Research Reviews.2013; 12(1): 8.     CrossRef
Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice
Jakob Voelkl, Ioana Alesutan, Christina B. Leibrock, Leticia Quintanilla-Martinez, Volker Kuhn, Martina Feger, Sobuj Mia, Mohamed S.E. Ahmed, Kevin P. Rosenblatt, Makoto Kuro-o, Florian Lang
Journal of Clinical Investigation.2013;[Epub]     CrossRef
Biochemical Markers of Aging for Longitudinal Studies in Humans
P. M. Engelfriet, E. H. J. M. Jansen, H. S. J. Picavet, M. E. T. Dolle
Epidemiologic Reviews.2013; 35(1): 132.     CrossRef
Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms
Rüdiger Hardeland
Journal of Pineal Research.2013; 55(4): 325.     CrossRef
Sepsis-Induced Hypercytokinemia and Lymphocyte Apoptosis in Aging-Accelerated Klotho Knockout Mice
Shigeaki Inoue, Takehito Sato, Kyoko Suzuki-Utsunomiya, Yukako Komori, Katsuto Hozumi, Tomoki Chiba, Takashi Yahata, Kozo Nakai, Sadaki Inokuchi
Shock.2013; 39(3): 311.     CrossRef
Vitamin D: Health panacea or false prophet?
Michael J. Glade
Nutrition.2013; 29(1): 37.     CrossRef
Altered regulation of cytosolic Ca2+ concentration in dendritic cells from klotho hypomorphic mice
Ekaterina Shumilina, Meerim K. Nurbaeva, Wenting Yang, Evi Schmid, Kalina Szteyn, Antonella Russo, Nicole Heise, Christina Leibrock, Nguyen Thi Xuan, Caterina Faggio, Makoto Kuro-o, Florian Lang
American Journal of Physiology-Cell Physiology.2013; 305(1): C70.     CrossRef
Aging and Chronic Kidney Disease
Kosaku Nitta, Kazuyoshi Okada, Mitsuru Yanai, Susumu Takahashi
Kidney and Blood Pressure Research.2013; 38(1): 109.     CrossRef
Cardiovascular Risk and Mineral Bone Disorder in Patients with Chronic Kidney Disease
Hagen Staude, Susann Jeske, Karin Schmitz, Gert Warncke, Dagmar-Christiane Fischer
Kidney and Blood Pressure Research.2013; 37(1): 68.     CrossRef
Small-Molecule Klotho Enhancers As Novel Treatment Of Neurodegeneration
Carmela R Abraham, CiDi Chen, Gregory D Cuny, Marcie A Glicksman, Ella Zeldich
Future Medicinal Chemistry.2012; 4(13): 1671.     CrossRef
Pathophysiology of the aging kidney and therapeutic interventions
Keizo Kanasaki, Munehiro Kitada, Daisuke Koya
Hypertension Research.2012; 35(12): 1121.     CrossRef
Identification of blood biomarkers of aging by transcript profiling of whole blood
Seiji Nakamura, Kozo Kawai, Yumie Takeshita, Masao Honda, Toshinari Takamura, Shuichi Kaneko, Ryo Matoba, Kenichi Matsubara
Biochemical and Biophysical Research Communications.2012; 418(2): 313.     CrossRef
‘Time and Time Again’: Oscillatory and Longitudinal Time Patterns in Dialysis Patients
Jeroen P. Kooman, Len Usvyat, Frank M. van der Sande, Stephan Thyssen, Nathan Levin, Karel M. Leunissen, Peter Kotanko
Kidney and Blood Pressure Research.2012; 35(6): 534.     CrossRef
Impact of serum calcium and phosphate on coronary atherosclerosis detected by cardiac computed tomography
Sanghoon Shin, Kwang-Joon Kim, Hyuk-Jae Chang, Iksung Cho, Young Jin Kim, Byoung-Wook Choi, Yumie Rhee, Sung-Kil Lim, Woo-In Yang, Chi-Young Shim, Jong-Won Ha, Yangsoo Jang, Namsik Chung
European Heart Journal.2012; 33(22): 2873.     CrossRef
Age-Associated Molecular Changes in the Kidney in Aged Mice
Ji Hee Lim, Eun Nim Kim, Min Young Kim, Sungjin Chung, Seok Joon Shin, Hyung Wook Kim, Chul Woo Yang, Yong-Soo Kim, Yoon Sik Chang, Cheol Whee Park, Bum Soon Choi
Oxidative Medicine and Cellular Longevity.2012; 2012: 1.     CrossRef
Aging biology: a new frontier for drug discovery
Ester Verdaguer, Felix Junyent, Jaume Folch, Carlos Beas-Zarate, Carme Auladell, Mercè Pallàs, Antoni Camins
Expert Opinion on Drug Discovery.2012; 7(3): 217.     CrossRef
The effects of oxygen tension and antiaging factor Klothoon Wnt signaling in nucleus pulposus cells
Akihiko Hiyama, Fumiyuki Arai, Daisuke Sakai, Katsuya Yokoyama, Joji Mochida
Arthritis Research & Therapy.2012;[Epub]     CrossRef
Dehydration: a new modulator of klotho expression
Miriam Zacchia, Giovambattista Capasso
American Journal of Physiology-Renal Physiology.2011; 301(4): F743.     CrossRef