Background/Aims: This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts.
Methods: Primary human dermal fibroblasts were separated from normal human skin samples. Under heat stress, the levels of miR-16 and heat shock protein 7..
Background/Aims: Little is known about tenofovir disoproxil fumarate (TDF)-induced nephrotoxicity in human immunodeficiency virus (HIV)-infected patients in Korea. The objective of this study was to evaluate the incidence and risk factors of TDF-associated nephrotoxicity among HIV-infected patients ..
Background/Aims: Methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) is a major bloodstream infection with a high mortality rate. Identification of factors associated with early mortality in MRSAB patients would be useful for predicting prognosis and developing new therapeutic opti..
Background/Aims: Adverse drug reaction (ADR) is an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product. The present study was conducted in order to monitor the frequency and severity of ADR during antimicrobial therapy of septicemia.
Background/Aims: We evaluated the effects of a multifaceted intervention for controlling a carbapenem-resistant Acinetobacter baumannii (CRAB) epidemic in an intensive care unit (ICU) with no restrictions on carbapenem use.
Methods: This study was conducted in a medical ICU between April 201..
Background/Aims: Infections following liver transplant (LT) remain a major cause of mortality. This study was conducted to evaluate risk factors for infection and to review clinical characteristics.
Methods: Medical records of patients who underwent LT from 2010 to 2014 were retrospectively analyze..
Background/Aims: Klebsiella pneumoniae is second most common organism of gram-negative bacteremia in Korea and one of the most common cause of urinary tract infection, and intra-abdominal infection.
Methods: We compared clinical and microbiological characteristics about K. pneumoniae ..
Background/Aims: Due to advances in diagnostic techniques, clinicians are more frequently performing influenza diagnostic tests and referring to their test results ahead of the administration of neuraminidase inhibitors (NAIs). To investigate the clinical significance of the time from symptom onset ..
Background/Aims: Procalcitonin (PCT) may prove to be a useful marker to exclude or predict bloodstream infection (BSI). However, the ability of PCT levels to differentiate BSI from non-BSI episodes has not been evaluated in nosocomial BSI.
Methods: We retrospectively reviewed the medical records of..
Background/Aims: Brucellosis patients present various non-specific clinical symptoms, such as fever, fatigue, sweating, joint pain, arthritis, myalgia, and headache. Based on the nonspecifity of its clinical signs and symtoms, we decided to evaluate whether mean platelet volume (MPV) , neutrophil to..
Sung-Han Kim, Ho-Su Lee, Hyun-Jung Lee, Sun-Mi Kim, Sung Shin, Sang-Hyoung Park, Kyung-Jo Kim, Young-Hoon Kim, Heungsup Sung, Sang-Oh Lee, Sang-Ho Choi, Suk-Kyun Yang, Yang Soo Kim, Jun Hee Woo, Duck-Jong Han
Korean J Intern Med. 2017;32(5):900-909. Published online August 23, 2017
Background/Aims: We evaluated the proposed clinical application of the combined interpretation of host factors and viral factors in two different cytomegalovirus (CMV) co-infection models.
Methods: We prospectively enrolled all human immunodeficiency virus non-infected patients with confirmed P..
Invasive aspergillosis (IA) is one of the most common life-threatening complications in immunocompromised patients. Voriconazole is currently the drug of choice for IA treatment. However, some patients with IA suffer clinical deterioration despite voriconazole therapy. Management of voriconazole-ref..
Background/Aims: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus. As yet, there is no effective antiviral therapy for SFTS. Ribavirin is a broad-spectrum antiviral agent, whic..
Background/Aims: Cat-scratch disease (CSD), caused by Bartonella henselae is one of the most common zoonosis. However, only several cases of B. henselae infection have been reported in Korea. This study investigated the seroprevalence of B. henselae in healthy adults and related..
Background/Aims: The pathogen Acinetobacter baumannii is increasingly causing healthcare-associated infections worldwide, particularly in intensive care units. Biofilm formation, a factor contributing to the virulence of A. baumannii, is associated with long-term persistence in hospita..
Background/Aims: Although multidrug resistance (MDR) among extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) poses significant therapeutic challenges, little is known regarding the risk factors and epidemiology of community-onset MDR‑ESBL‑EC infections. We performed this study t..
Background/Aims: Healthcare-associated infections (HAIs) in critically ill patients with prolonged length of hospital stay and increased medical costs. The aim of this study is to assess whether daily chlorhexidine gluconate (CHG) bathing will significantly reduce the rates of HAIs in adult intensiv..
Tark Kim, Yu-Mi Lee, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Heungsup Sung, Joo Hee Jung, Sung Shin, Young Hoon Kim, Young-Ah Kang, Young-Shin Lee, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Lee, Su-Kil Park, Duck Jong Han, Sung-Han Kim
Korean J Intern Med. 2016;31(5):961-970. Published online April 8, 2016
Background/Aims: Cytomegalovirus (CMV) surveillance and preemptive therapy is a widely-used strategy for preventing CMV disease in transplant recipients. However, there are limited data on the incidence and patterns of CMV disease during the preemptive period. Thus, we investigated the incidence and..
Youn Jeong Kim, Jun Hee Woo, Min Ja Kim, Dae Won Park, Joon-Young Song, Shin Woo Kim, Jun Yong Choi, June Myung Kim, Sang Hoon Han, Jin-Soo Lee, Bo Youl Choi, Joo Shil Lee, Sung-Soon Kim, Mee-Kyung Kee, Moon Won Kang, Sang Il Kim
Korean J Intern Med. 2016;31(5):953-960. Published online April 27, 2016
Background/Aims: The frequencies of opportunistic diseases (ODs) vary across countries based on genetic, environmental, and social differences. The Korean HIV/AIDS cohort study was initiated in 2006 to promote research on human immunodeficiency virus (HIV) infection in Korea, and to provide a logist..
Background/Aims: Increasing incidences of hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-infected men who have sex were reported in the United States and Europe. However, few studies regarding the epidemiology of HCV infection in HIV-infected patients in Asian countries have..