Korean J Intern Med > Volume 34(3); 2019 > Article |
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Variable | Sarcopenia (n = 47, 33.1%) | No sarcopenia (n = 95, 66.9%) | p value |
---|---|---|---|
Age, yr | 62.4 ± 14.0 | 59.2 ± 13.0 | 0.178 |
Male sex | 24 (51.1) | 57 (60.0) | 0.311 |
Body mass index, kg/m2 | 21. 9 ± 2.8 | 22.7 ± 3.5 | 0.146 |
Triceps muscle thickness, mm | 1.0 ± 0.5 | 1.1 ± 0.3 | 0.485 |
Cause of end-stage renal disease | 0.541 | ||
Diabetic | 29 (61.7) | 48 (50.5) | |
Hypertensive | 12 (25.5) | 25 (26.3) | |
Glomerulonephritis | 3 (6.4) | 14 (14.7) | |
Others | 3 (6.4) | 8 (8.5) | |
Coronary artery disease | 14 (29.8) | 21 (22.1) | 0.502 |
Cerebrovascular disease | 14 (29.8) | 19 (20.0) | 0.326 |
Duration of dialysis, mon | 50.7 ± 41.9 | 50.0 ± 50.6 | 0.934 |
Mean arterial pressure, mmHg | 98.1 ± 22.2 | 105.0 ± 11.4 | 0.053 |
Hemoglobin, g/dL | 10.3 ± 1.0 | 10.0 ± 0.8 | 0.099 |
Glucose, mg/dL | 130.0 ± 90 | 112.7 ± 49.2 | 0.198 |
Albumin, g/dL | 3.7 ± 0.3 | 3.8 ± 0.4 | 0.580 |
Prealbumin, mg/dL | 23.5 ± 10.9 | 27.3 ± 8.0 | 0.103 |
HDL-C, mg/dL | 44.5 ± 13.1 | 44.8 ± 11.6 | 0.900 |
LDL-C, mg/dL | 74.8 ± 30.5 | 79.5 ± 24.8 | 0.390 |
Triglyceride, mg/dL | 92.1 ± 55.6 | 85.0 ± 43.0 | 0.465 |
Uric acid, mg/dL | 10.3 ± 16.5 | 7.7 ± 1.5 | 0.355 |
Serum ferritin, μg/L | 214.4 ± 167.3 | 199.8 ± 110.4 | 0.590 |
Intact parathyroid hormone, pg/mL | 175.9 ± 270.9 | 171.7 ± 197.9 | 0.929 |
β2-Microglobulin, mg/L | 29.2 ± 9.2 | 24.7 ± 7.1 | 0.013 |
25-Hydroxyvitamin D, ng/mL | 7.4 ± 4.0 | 10.4 ± 5.0 | 0.002 |
hs-CRPa | 0.8 ± 1.3 | –0.2 ± 1.2 | 0.001 |
HbA1c, % | 7.5 ± 1.4 | 6.8 ± 1.1 | 0.038 |
spKt/V | 1.5 ± 0.4 | 1.5 ± 0.2 | 0.668 |
nPCR, g/kg/day | 1.1 ± 0.3 | 1.1 ± 0.3 | 0.919 |
SGA, score | 5.3 ± 1.4 | 6.1 ± 0.7 | 0.008 |
Overhydration, L | 0.8 ± 2.4 | 0.2 ± 2.6 | 0.725 |
Lean tissue index, kg/m2 | 11.0 ± 2.2 | 13.9 ± 2.9 | < 0.001 |
Fat tissue index, kg/m2 | 10.6 ± 3.7 | 8.4 ± 4.3 | 0.004 |
Handgrip strength, kg | 18.2 ± 6.5 | 27.2 ± 8 | < 0.001 |
Values are presented as mean ± SD or number (%).
HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; hs-CRP, high-sensitivity C-reactive protein; HbA1c, glycated hemoglobin; spKt/V, single pool Kt/V; nPCR, normalized protein catabolism rate; SGA, Subjective Global Assessment.
Variable | LTI | FTI | HGS | BMI | Triceps | SGA | Albumin | Prealbumin | hs-CRP |
---|---|---|---|---|---|---|---|---|---|
LTI | –0.481a | 0.544a | 0.158 | –0.106 | 0.243a | 0.041 | 0.014 | –0.146 | |
FTI | –0.481a | –0.411a | 0.645a | 0.421a | –0.080 | 0.009 | 0.035 | 0.137 | |
HGS | 0.544a | –0.411a | 0.022 | –0.101 | 0.347a | 0.036 | 0.172 | –0.241a | |
BMI | 0.158 | 0.645a | 0.022 | 0.489a | 0.158 | 0.184 | 0.113 | 0.103 | |
Triceps | –0.106 | 0.489a | –0.101 | 0.489a | 0.281a | 0.155 | 0.384a | 0.060 | |
SGA | 0.243a | 0.158 | 0.347a | 0.158 | 0.281a | 0.106 | 0.396a | –0.201 | |
Albumin | 0.041 | 0.184 | 0.036 | 0.041 | 0.155 | 0.106 | 0.314a | –0.157 | |
Prealbumin | 0.014 | 0.113 | 0.172 | 0.014 | 0.384a | 0.396a | 0.314a | –0.093 | |
hs-CRPb | –0.146 | 0.103 | –0.241a | 0.103 | 0.060 | –0.201 | –0.157 | –0.093 |
Variable |
All-cause mortality |
Cardiovascular events |
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---|---|---|---|---|---|---|
Hazard ratio | 95% CI | p value | Hazard ratio | 95% CI | p value | |
Age | 1.06 | 1.00–1.02 | 0.003 | 1.10 | 1.04–1.15 | < 0.001 |
Sex | 0.46 | 0.17–2.22 | 0.457 | 0.25 | 0.05–1.21 | 0.084 |
Diabetes | 1.95 | 0.63–10.5 | 0.437 | 1.08 | 0.15–7.90 | 0.943 |
Coronary artery disease | 3.57 | 1.40–9.11 | 0.008 | 7.07 | 2.11–23.74 | 0.002 |
Cerebrovascular disease | 0.72 | 0.67–1.96 | 0.518 | 1.44 | 0.51–4.12 | 0.493 |
BMI, kg/m2 | 1.01 | 0.85–1.21 | 0.907 | 1.20 | 1.00–1.44 | 0.053 |
hs-CRPa | 2.53 | 1.73–3.68 | 0.001 | 1.41 | 0.98–2.03 | 0.640 |
SGA (B vs. A) | 6.71 | 2.13–21.08 | 0.001 | 0.87 | 0.34–3.18 | 0.827 |
Albumin | 0.39 | 0.10–1.57 | 0.185 | 0.59 | 0.12–2.89 | 0.512 |
Low lean tissue index | 2.77 | 1.10–6.97 | 0.030 | 3.01 | 1.09–8.29 | 0.033 |
Low handgrip strength | 5.65 | 1.99–16.04 | 0.001 | 4.09 | 1.26–13.29 | 0.019 |
Sarcopenia | 6.99 | 1.84–26.58 | 0.004 | 4.33 | 1.51–12.43 | 0.006 |
Multivariate Cox regression analysis was performed after adjusting for age, gender, BMI, Kt/V, albumin, diabetes, dialysis vintage, hs-CRP and previous history of coronary artery disease and cerebrovascular disease.
CI, confidence interval; BMI, body mass index; hs-CRP, high-sensitivity C-reactive protein; SGA, Subjective Global Assessment.