KJIM :: Korean Journal of Internal Medicine

Cyclosporine-induced kidney damage was halted by sitagliptin and hesperidin via increasing Nrf2 and suppressing TNF-α, NF-κB, and Bax

Ahmed M. Abd-Eldayem, Sohayla Mahmoud Makram, Basim Anwar Shehata Messiha, Hanan H. Abd-Elhafeez, Mustafa Ahmed Abdel-Reheim

Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease

Javier Donate-Correa, Beatriz Martín-Carro, Jorge B. Cannata-Andía, Carmen Mora-Fernández, Juan F. Navarro-González

Amelioration of Cyclosporine A-Induced Acute Nephrotoxicity by Cordyceps cicadae Mycelia via Mg+2 Reabsorption and the Inhibition of GRP78-IRE1-CHOP Pathway: In Vivo and In Vitro

Zong-Han Wu, Chun-Hung Chiu, Chin-Chu Chen, Charng-Cherng Chyau, Chi-Hung Cheng

International Journal of Molecular Sciences.2023; 24(1): 772. CrossRef

The effect of glycine on oxidative stress, inflammation and renin-angiotensin system in kidneys and aorta of cyclosporine-administered rats

Rivaze Kalaycı, İlknur Bingül, Merva Soluk-Tekkeşin, Vakur Olgaç, Seldağ Bekpınar, Müjdat Uysal

Drug and Chemical Toxicology.2023; : 1. CrossRef

Role of TGF-β1 +869T>C polymorphism in renal dysfunction one year after heart transplantation

Jorge V. López-Ibor, María J. Citores, Jose Portoles, Manuel Gómez-Bueno, Beatriz Sánchez-Sobrino, Alejandro Muñoz, Valentín Cuervas-Mons, Javier Segovia-Cubero

The Journal of Heart and Lung Transplantation.2022; 41(12): 1672. CrossRef

The protective effect of resveratrol against cyclosporine A-induced oxidative stress and hepatotoxicity

Ilknur Bingul, Vakur Olgac, Seldag Bekpinar, Mujdat Uysal

Archives of Physiology and Biochemistry.2021; 127(6): 551. CrossRef

Inhibition of oxidative stress and apoptosis by camel milk mitigates cyclosporine‐induced nephrotoxicity: Targeting Nrf2/HO‐1 and AKT/eNOS/NO pathways

Hany H. Arab, Ahmed H. Eid, Amany M. Gad, Rania Yahia, Ayman M. Mahmoud, Ahmed M. Kabel

Food Science & Nutrition.2021; 9(6): 3177. CrossRef

Avocado Seeds Relieve Oxidative Stress-Dependent Nephrotoxicity but Enhance Immunosuppression Induced by Cyclosporine in Rats

Amira M. Elmoslemany, Mohammed A. El-Magd, Heba I. Ghamry, Mohammad Y. Alshahrani, Nahla S. Zidan, Amina M. G. Zedan

Human kidney organoids model the tacrolimus nephrotoxicity and elucidate the role of autophagy

Jin Won Kim, Sun Ah Nam, Eunjeong Seo, Jong Young Lee, Dohui Kim, Ji Hyeon Ju, Sun Woo Lim, Hong Lim Kim, Hyung Wook Kim, Chul Woo Yang, Jin Kim, Dong Sung Kim, Yong Kyun kim

The Korean Journal of Internal Medicine.2021; 36(6): 1420. CrossRef

Tacrolimus Decreases Cognitive Function by Impairing Hippocampal Synaptic Balance: a Possible Role of Klotho

Yoo Jin Shin, Sun Woo Lim, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Hong Lim Kim, Tae Ryong Riew, Mun Yong Lee, Chul Woo Yang

Molecular Neurobiology.2021; 58(11): 5954. CrossRef

Effect of biochemical and biomechanical factors on vascularization of kidney organoid-on-a-chip

Han Na Lee, Yoon Young Choi, Jin Won Kim, Young Seo Lee, Ji Wook Choi, Taewook Kang, Yong Kyun Kim, Bong Guen Chung

Nontoxic concentration of ochratoxin A decreases the dosage of cyclosporine A to induce chronic nephropathy model via autophagy mediated by toll-like receptor 4

Lili Hou, Guannan Le, Ziman Lin, Gang Qian, Fang Gan, Cong Gu, Shuai Jiang, Jiaxin Mu, Lei Ge, Kehe Huang

Cell Death & Disease.2020;[Epub] CrossRef

The safety, immunological benefits, and efficacy of ginseng in organ transplantation

Sun Woo Lim, Kang Luo, Yi Quan, Sheng Cui, Yoo Jin Shin, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang

Journal of Ginseng Research.2020; 44(3): 399. CrossRef

Apocynin and catalase prevent hypertension and kidney injury in Cyclosporine A-induced nephrotoxicity in rats

Yong Chia Tan, Munavvar Abdul Sattar, Ahmad F. Ahmeda, Nurzalina Abdul Karim Khan, Vikneswaran Murugaiyah, Ashfaq Ahmad, Zurina Hassan, Gurjeet Kaur, Mohammed Hadi Abdulla, Edward James Johns, Partha Mukhopadhyay

Cyclosporine A induces kidney dysfunction by the alteration of molecular mediators involved in slit diaphragm regulation and matrix metalloproteins: the mitigating effect of curcumin

Mona Niazi, Alireza Shirpoor, Ali Taghizadeh Afshari, Roya Naderi, Morteza Bagheri, Masoumeh Pourjabali, Yousef Rasmi

Expert Opinion on Drug Metabolism & Toxicology.2020; 16(12): 1223. CrossRef

Influence of Tacrolimus on Depressive-Like Behavior in Diabetic Rats Through Brain-Derived Neurotrophic Factor Regulation in the Hippocampus

Yoo Jin Shin, Yeon Tae Chun, Sun Woo Lim, Kang Luo, Yi Quan, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Jiyeong Lee, Seongno Hong, Mun Yong Lee, Hee Gyoo Kang, Chul Woo Yang

Neurotoxicity Research.2019; 36(2): 396. CrossRef

Cilastatin protects against tacrolimus-induced nephrotoxicity via anti-oxidative and anti-apoptotic properties

Kang Luo, Sun Woo Lim, Jian Jin, Long Jin, Hyo Wook Gil, Dai Sig Im, Hyeon Seok Hwang, Chul Woo Yang

Ameliorated and antioxidant effects of Fucoidan against cyclosporine A-induced kidney injury in rats

Bushra Y. H. Al-Khatib, Nada M. H. Al-Hamdani, Hussein S. A. Gumaih

The Journal of Basic and Applied Zoology.2019;[Epub] CrossRef

Resveratrol ameliorates the cyclosporine-induced vascular and renal impairments: possible impact of the modulation of renin–angiotensin system

Seldag Bekpinar, Ece Karaca, Selin Yamakoğlu, F. İlkay Alp-Yıldırım, Vakur Olgac, B. Sönmez Uydes-Doğan, Ezgi Cibali, Suleyman Gultepe, Mujdat Uysal

Canadian Journal of Physiology and Pharmacology.2019; 97(12): 1115. CrossRef

Serum 25-hydroxyvitamin D is associated with renal fi brosis (experimental study)

E. O. Bogdanova, G. T. Ivanova, O. V. Galkina, I. M. Zubina, O. N. Beresneva, M. M. Parastaeva, I. G. Kayukov, V. A. Dobronravov

Nephrology (Saint-Petersburg).2019; 23(6): 100. CrossRef

Role of Klotho in Chronic Calcineurin Inhibitor Nephropathy

Kang Luo, Sun Woo Lim, Yi Quan, Sheng Cui, Yoo Jin Shin, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang

Oxidative Medicine and Cellular Longevity.2019; 2019: 1. CrossRef

Coenzyme Q 10 alleviates tacrolimus‐induced mitochondrial dysfunction in kidney

Ji Hyun Yu, Sun Woo Lim, Kang Luo, Sheng Cui, Yi Quan, Yoo Jin Shin, Kyung Eun Lee, Hong Lim Kim, Eun Jeong Ko, Byung Ha Chung, Ju Hwan Kim, Sang J. Chung, Chul Woo Yang

The FASEB Journal.2019; 33(11): 12288. CrossRef

Ginseng increases Klotho expression by FoxO3-mediated manganese superoxide dismutase in a mouse model of tacrolimus-induced renal injury

Sun Woo Lim, Yoo Jin Shin, Kang Luo, Yi Quan, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang

Mechanism of cyclosporine A nephrotoxicity: Oxidative stress, autophagy, and signalings

Qinghua Wu, Xu Wang, Eugenie Nepovimova, Yun Wang, Hualin Yang, Kamil Kuca

Food and Chemical Toxicology.2018; 118: 889. CrossRef

Combining Extracellular miRNA Determination with Microfluidic 3D Cell Cultures for the Assessment of Nephrotoxicity: a Proof of Concept Study

Laura Suter-Dick, L. Mauch, D. Ramp, M. Caj, M. K. Vormann, S. Hutter, H. L. Lanz, J. Vriend, R. Masereeuw, M. J. Wilmer

Klotho mitigates cyclosporine A (CsA)-induced epithelial–mesenchymal transition (EMT) and renal fibrosis in rats

Qi-feng Liu, Jian-ming Ye, Li-xia Yu, Xiao-hong Dong, Jian-hua Feng, Yan Xiong, Xiao-xia Gu, Sha-sha Li

International Urology and Nephrology.2017; 49(2): 345. CrossRef

The Protective Effect of Febuxostat on Chronic Tacrolimus-Induced Nephrotoxicity in Rats

Hyun Seon Kim, Sun Woo Lim, Long Jin, Jian Jin, Byung Ha Chung, Chul Woo Yang

Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress

Sun Woo Lim, Long Jin, Kang Luo, Jian Jin, Yoo Jin Shin, Sung Yi Hong, Chul Woo Yang

Cell Death & Disease.2017; 8(8): e2972. CrossRef

The clinical characteristics of posterior reversible encephalopathy syndrome in patients with chronic renal failure

Hongtao Hu, Shen Xu, Shuang Hu, Weijia Xu, Hua Shui

Experimental and Therapeutic Medicine.2017; 14(1): 881. CrossRef

The protective effect of neutralizing high-mobility group box1 against chronic cyclosporine nephrotoxicity in mice

Hoon Suk Park, Eun Nim Kim, Min Young Kim, Ji Hee Lim, Hyung Wook Kim, Cheol Whee Park, Chul Woo Yang, Dong Chan Jin, Bum Soon Choi

Transplant Immunology.2016; 34: 42. CrossRef

Influence of cyclosporine A on glomerular growth and the effect of mizoribine and losartan on cyclosporine nephrotoxicity in young rats

Ji Hong Kim, Yeon Hee Lee, Beom Jin Lim, Hyeon Joo Jeong, Pyung Kil Kim, Jae Il Shin

Amelioration of cyclosporine induced nephrotoxicity by dipeptidyl peptidase inhibitor vildagliptin

International Immunopharmacology.2015; 28(1): 571. CrossRef

Inhibition of dipeptidyl peptidase IV protects tacrolimus-induced kidney injury

Sun W Lim, Long Jin, Shang G Piao, Byung H Chung, Chul W Yang

Laboratory Investigation.2015; 95(10): 1174. CrossRef

TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy and reduces renal dysfunction in a cyclosporine A-induced nephrotoxicity model

Raj Kumar Yadav, Geum-Hwa Lee, Hwa-Young Lee, Bo Li, Han-Eul Jung, Harun-Or Rashid, Min Kyung Choi, Binod Kumar Yadav, Woo-Ho Kim, Kyung-Woon Kim, Byung-Hyun Park, Won Kim, Yong-Chul Lee, Hyung-Ryong Kim, Han-Jung Chae

Nanoparticles in drug delivery: mechanism of action, formulation and clinical application towards reduction in drug-associated nephrotoxicity

Dustin L Cooper, Christopher M Conder, Sam Harirforoosh

Expert Opinion on Drug Delivery.2014; 11(10): 1661. CrossRef

The Korean Journal of Internal Medicine.2014; 29(4): 416. CrossRef

Ginseng treatment attenuates autophagic cell death in chronic cyclosporine nephropathy

Sun Woo Lim, Kyoung Chan Doh, Long Jin, Jian Jin, Shang Guo Piao, Seong Beom Heo, Byung Ha Chung, Chul Woo Yang

Role of protein kinase A signaling pathway in cyclosporine nephrotoxicity

F. D. França, A. F. Ferreira, R. C. Lara, J. V. Rossoni, D. C. Costa, K. C. M. Moraes, D. A. Gomes, C. A. Tagliati, M. M. Chaves

Toxicology Mechanisms and Methods.2014; 24(6): 369. CrossRef

The renin-angiotensin system and aging in the kidney

The Korean Journal of Internal Medicine.2014; 29(3): 291. CrossRef

Alteration in cellular viability, pro‐inflammatory cytokines and nitric oxide production in nephrotoxicity generation by Amphotericin B: involvement of PKA pathway signaling

F. D. França, A. F. Ferreira, R. C. Lara, J. V. Rossoni, D. C. Costa, K. C. M. Moraes, C. A. Tagliati, M. M. Chaves

Journal of Applied Toxicology.2014; 34(12): 1285. CrossRef

Combined Treatment of Tacrolimus and Everolimus Increases Oxidative Stress by Pharmacological Interactions

Shang Guo Piao, Sun Woo Lim, Kyoung Chan Doh, Long Jin, Seong Beom Heo, Yu Fen Zheng, Su Kyung Bae, Byung Ha Chung, Can Li, Chul Woo Yang

Transplantation.2014; 98(1): 22. CrossRef

Cyclosporine A Induces Apoptotic and Autophagic Cell Death in Rat Pituitary GH3 Cells

Han Sung Kim, Seung-Il Choi, Eui-Bae Jeung, Yeong-Min Yoo, Ilya Ulasov

Endoplasmic reticulum stress triggers autophagy in malignant glioma cells undergoing cyclosporine A-induced cell death

I A Ciechomska, K Gabrusiewicz, A A Szczepankiewicz, B Kaminska

Sildenafil protects against nitric oxide deficiency-related nephrotoxicity in cyclosporine A treated rats

Rania G. Abdel-latif, Mohamed A. Morsy, Mohamed A. El-Moselhy, Mohamed A. Khalifa

European Journal of Pharmacology.2013; 705(1-3): 126. CrossRef

N-acetylcysteine for the prevention of non-contrast media agent-induced kidney injury: from preclinical data to clinical evidence

Hesamoddin Hosseinjani, Azadeh Moghaddas, Hossein Khalili

European Journal of Clinical Pharmacology.2013; 69(7): 1375. CrossRef

The immunomodulating and antioxidant activity of fucoidan on the splenic tissue of rats treated with cyclosporine A

Hossam El-Din M. Omar, Heba M. Saad Eldien, Mohammed Saad Badary, Bushra Y. Al-Khatib, Sary Kh. AbdElgaffar

The Journal of Basic & Applied Zoology.2013; 66(5): 243. CrossRef

Ginseng Treatment Attenuates Chronic Cyclosporine Nephropathy via Reducing Oxidative Stress in an Experimental Mouse Model

Kyoung Chan Doh, Sun Woo Lim, Shang Guo Piao, Long Jin, Seong Beom Heo, Yu Fen Zheng, Soo Kyung Bae, Gyu Hyun Hwang, Kyoung Il Min, Byung Ha Chung, Chul Woo Yang

American Journal of Nephrology.2013; 37(5): 421. CrossRef

Influence of N-Acetylcysteine on Klotho Expression and Its Signaling Pathway in Experimental Model of Chronic Cyclosporine Nephropathy in Mice

Shang Guo Piao, Seok Hui Kang, Sun Woo Lim, Byung Ha Chung, Kyoung Chan Doh, Seong Beom Heo, Long Jin, Can Li, Chul Woo Yang

Transplantation.2013; 96(2): 146. CrossRef

Human Adipose Tissue Derived Mesenchymal Stem Cells Aggravate Chronic Cyclosporin Nephrotoxicity by the Induction of Oxidative Stress

Byung Ha Chung, Sun Woo Lim, Kyoung Chan Doh, Shang Guo Piao, Seong Beom Heo, Chul Woo Yang, Ivan Cruz Moura

Oral Administration of Ginseng Ameliorates Cyclosporine-Induced Pancreatic Injury in an Experimental Mouse Model

Sun Woo Lim, Kyoung Chan Doh, Long Jin, Shang Guo Piao, Seong Beom Heo, Yu Fen Zheng, Soo Kyung Bae, Byung Ha Chung, Chul Woo Yang, Frederick G. Hamel

Chronic Cyclosporine Nephropathy Is Characterized by Excessive Autophagosome Formation and Decreased Autophagic Clearance

Sun Woo Lim, Bok Jin Hyoung, Shang Guo Piao, Kyoung Chan Doh, Byung Ha Chung, Chul Woo Yang

Transplantation.2012; 94(3): 218. CrossRef

Statin Upregulates the Expression of Klotho, an Anti-Aging Gene, in Experimental Cyclosporine Nephropathy

Hye Eun Yoon, Sun Woo Lim, Shang Guo Piao, Ji-Hyun Song, Jin Kim, Chul Woo Yang

Nephron Experimental Nephrology.2012; 120(4): e123. CrossRef

Comparison of Early and Late Conversion of Sirolimus in Experimental Model of Chronic Cyclosporine Nephropathy

Jin Young Kim, Jung Yeon Ghee, Sun Woo Lim, Shang Guo Piao, Byung Ha Chung, Hye Eun Yoon, Hyeon Seok Hwang, Bum Soon Choi, Jin Kim, Chul Woo Yang

Journal of Korean Medical Science.2012; 27(2): 160. CrossRef

Drug Interaction Between Cyclosporine and mTOR Inhibitors in Experimental Model of Chronic Cyclosporine Nephrotoxicity and Pancreatic Islet Dysfunction

Shang Guo Piao, Soo Kyung Bae, Sun Woo Lim, Ji-Hyun Song, Byung Ha Chung, Bum Soon Choi, Chul Woo Yang

Transplantation.2012; 93(4): 383. CrossRef

Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow

Ş. Remzi Erdem, Selda Emre-Aydıngöz, Pergin Atilla, A. Nur Çakar, Turgay Dalkara, Hayrunnisa Bolay, Meral Tuncer

Life Sciences.2011; 88(17-18): 753. CrossRef

Early and delayed effects of AST-120 on chronic cyclosporine nephropathy

S. H. Kim, J. Y. Ghee, S. Piao, D. H. Han, J.-H. Song, H. E. Yoon, B. S. Choi, J. Kim, F. Nishijima, K. Obara, N. Ishikawa, C. W. Yang

Nephrology Dialysis Transplantation.2011; 26(5): 1502. CrossRef

Renoprotective effects of green tea extract on renin-angiotensin-aldosterone system in chronic cyclosporine-treated rats

H. H. Ryu, H. L. Kim, J. H. Chung, B. R. Lee, T. H. Kim, B. C. Shin

Nephrology Dialysis Transplantation.2011; 26(4): 1188. CrossRef

Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy

H. E. Yoon, J. Y. Ghee, S. Piao, J.-H. Song, D. H. Han, S. Kim, N. Ohashi, H. Kobori, M. Kuro-o, C. W. Yang

Nephrology Dialysis Transplantation.2011; 26(3): 800. CrossRef

Effect of Sirolimus on Calcineurin Inhibitor-Induced Nephrotoxicity Using Renal Expression of KLOTHO, an Antiaging Gene

Dong He Han, Shang Guo Piao, Ji-Hyun Song, Jung Yeon Ghee, Hyeon Seok Hwang, Bum Soon Choi, Jin Kim, Chul Woo Yang

Transplantation.2010; 90(2): 135. CrossRef

Melatonin suppresses cyclosporine A‐induced autophagy in rat pituitary GH3 cells

Journal of Pineal Research.2010; 48(3): 204. CrossRef