| Reviews |
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Recent insights regarding the molecular basis of myeloproliferative neoplasms
Mi-Ae Jang, Chul Won Choi
Korean J Intern Med. 2020;35(1):1-11. Published online November 29, 2019
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal disorders characterized by the overproduction of mature blood cells that have an increased risk of thrombosis and progression to acute myeloid leukemia. Next-generation sequencing studies have provided key insights regarding the..
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Roles of mast cells in rheumatoid arthritis
Hong Ki Min, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Korean J Intern Med. 2020;35(1):12-24. Published online November 15, 2019
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory arthritis, and the complex interaction and activation of innate and adaptive immune cells are involved in RA pathogenesis. Mast cells (MCs) are one of the tissue-resident innate immune cells, and they contribute to RA pathogenesis. In th..
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Consensus regarding diagnosis and management of atypical hemolytic uremic syndrome
Hajeong Lee, Eunjeong Kang, Hee Gyung Kang, Young Hoon Kim, Jin Seok Kim, Hee-Jin Kim, Kyung Chul Moon, Tae Hyun Ban, Se Won Oh, Sang Kyung Jo, Heeyeon Cho, Bum Soon Choi, Junshik Hong, Hae Il Cheong, Doyeun Oh
Korean J Intern Med. 2020;35(1):25-40. Published online January 2, 2020
Thrombotic microangiopathy (TMA) is defined by specific clinical characteristics, including microangiopathic hemolytic anemia, thrombocytopenia, and pathologic evidence of endothelial cell damage, as well as the resulting ischemic end-organ injuries. A variety of clinical scenarios have features of ..
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| Guideline |
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The use of biological disease-modifying antirheumatic drugs for inflammatory arthritis in Korea: results of a Korean Expert Consensus
Eun-Jung Park, Hyungjin Kim, Seung Min Jung, Yoon-Kyoung Sung, Han Joo Baek, Jisoo Lee
Korean J Intern Med. 2020;35(1):41-59. Published online January 2, 2020
Biological disease-modifying antirheumatic drugs (bDMARDs) are highly effective agents for the treatment of inf lammatory arthritis; however, they also possess a potential risk for serious infection. Recently, with the rapid expansion of the bDMARDs market in Korea, reports of serious adverse events ..
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| Editorials |
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| Original Articles |
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Gastroenterology
Potential etiology, prevalence of cirrhosis, and mode of detection among patients with non-B non-C hepatocellular carcinoma in Korea
Jihye Kim, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
Korean J Intern Med. 2020;35(1):65-78. Published online June 17, 2019
Background/Aims: We systematically evaluated the clinical characteristics, prevalence of cirrhosis, and mode of detection in virus-unrelated (non-B non-C, NBNC) hepatocellular carcinoma (HCC) patients in Korea.
Methods: A total of 447 consecutive treatment-naïve NBNC-HCC adult patients who were r..
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Association between clinical risk factors and severity of dysphagia after extubation based on a videofluoroscopic swallowing study
Won-Jong Yang, Eunhee Park, Yu-Sun Min, Jae-Won Huh, Ae Ryoung Kim, Hyun-Min Oh, Tae-Woo Nam, Tae-Du Jung
Korean J Intern Med. 2020;35(1):79-87. Published online January 2, 2020
Background/Aims: This study aimed to evaluate the correlation between clinical risk factors of post-extubation dysphagia (PED) and the severity of impaired pharyngeal swallowing function assessed via videofluoroscopic swallowing studies (VFSSs).
Methods: This study was a retrospective review of med..
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Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
Jae Gon Lee, Joo Hyun Sohn, Jae Yoon Jeong, Tae Yeob Kim, Sun Min Kim, Young Seo Cho, Yongsoo Kim
Korean J Intern Med. 2020;35(1):88-98. Published online February 25, 2019
Background/Aims: Both hepatic venous pressure gradient (HVPG) and liver stiffness (LS) are useful tools for predicting mortality in patients with cirrhosis. We investigated the combined effect of HVPG and LS on long-term mortality in patients with cirrhosis.
Methods: We retrospectively collected da..
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Cardiology
A prospective survey of the persistence of warfarin or NOAC in nonvalvular atrial fibrillation: a COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF)
Hyeongsoo Kim, Young Soo Lee, Tae-Hoon Kim, Myung-Jin Cha, Jung Myung Lee, Junbeom Park, Jin-Kyu Park, Ki-Woon Kang, Jaemin Shim, Jae-Sun Uhm, Hyung Wook Park, Eue-Keun Choi, Jin-Bae Kim, Changsoo Kim, Jun Kim, Boyoung Joung
Korean J Intern Med. 2020;35(1):99-108. Published online April 25, 2019
Background/Aims: Efforts to reduce stroke in patients with atrial fibrillation (AF) have focused on increasing physician adherence to oral anticoagulant (OAC) guidelines; however, the high early discontinuation rate of vitamin K antagonists (VKAs) is a limitation. Although non-VKA OACs (NOACs) are m..
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Attitudes toward advance directives and prognosis in patients with heart failure: a pilot study
JinShil Kim, Minjeong An, Seongkum Heo, Mi-Seung Shin
Korean J Intern Med. 2020;35(1):109-118. Published online February 15, 2019
Background/Aims: Advance directives (ADs) in Korean patients with heart failure (HF) and the associations of attitude towards ADs and HF prognosis with ADs were initially assessed using the model of the Korean-Advance Directive (K-AD).
Methods: Twenty-four patients with HF (age, 67.1 years; men, 58..
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Pre-hospital delay and emergency medical services in acute myocardial infarction
Seung Hun Lee, Hyun Kuk Kim, Myung Ho Jeong, Joo Myung Lee, Hyeon-Cheol Gwon, Shung Chull Chae, In-Whan Seong, Jong-Seon Park, Jei Keon Chae, Seung-Ho Hur, Kwang Soo Cha, Hyo-Soo Kim, Ki-Bae Seung, Seung-Woon Rha, Tae Hoon Ahn, Chong-Jin Kim, Jin-Yong Hwang, Dong-Ju Choi, Junghan Yoon, Seung-Jae Joo, Kyung-Kuk Hwang, Doo-Il Kim, Seok Kyu Oh; for the KAMIR Investigators
Korean J Intern Med. 2020;35(1):119-132. Published online November 28, 2019
Background/Aims: Minimising total ischemic time (TIT) is important for improving clinical outcomes in patients with ST-segment elevation myocardial infarction who have undergone percutaneous coronary intervention (PCI). TIT has not shown a significant improvement due to persistent pre-hospital delay..
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Pulmonology
HL301 in the treatment of acute bronchitis: a phase 2b, randomized, double-blind, placebocontrolled, multicenter study
Sang Won Yoon, Myung Jae Park, Chin Kook Rhee, Joo Hun Park, Sang Yeub Lee, Do Jin Kim, Dong Gyu Kim, Jae Yeol Kim
Korean J Intern Med. 2020;35(1):133-141. Published online April 9, 2019
Background/Aims: There is insufficient quality data to recommend the use of herbs for the treatment of acute bronchitis. Small number of randomized trials of plant extracts for this purpose were determined to be low quality and there are concerns for the safety. HL301 is a combined product of seven ..
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Analysis of high predicted pulmonary function: possibility of overestimation in small elderly examinees
Youjin Chang, Ho Cheol Kim, Kyung-Wook Jo, Jae Seung Lee, Yeon-Mok Oh, Sang Do Lee, Sei Won Lee
Korean J Intern Med. 2020;35(1):142-149. Published online October 17, 2019
Background/Aims: Few studies have attempted to interpret unusually high predicted pulmonary function test results. This study aimed to investigate the demographic features of patients with an unusually high predicted pulmonary function.
Methods: The demographic data of subjects who underwent pulmon..
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Endocrinology-metabolism
Validation of the Friedewald formula for estimating low density lipoprotein cholesterol: the Korea National Health and Nutrition Examination Survey, 2009 to 2011
Jongseok Lee, Sungok Jang, Haemin Jeong, Ohk-Hyun Ryu
Korean J Intern Med. 2020;35(1):150-159. Published online March 21, 2018
Background/Aims: The aim of this study is to compare Friedewald-estimated and directly measured low density lipoprotein cholesterol (LDL-C) values and assess the concordance in guideline risk classification between the two methods.
Methods: The data were derived from the 2009 to 2011 Korea National..
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Nephrology
Low parathyroid hormone level predicts infection-related mortality in incident dialysis patients: a prospective cohort study
Yu Ah Hong, Jeong Ho Kim, Yong Kyun Kim, Yoon Kyung Chang, Cheol Whee Park, Suk Young Kim, Yon Su Kim, Shin-Wook Kang, Nam-Ho Kim, Yong-Lim Kim, Chul Woo Yang
Korean J Intern Med. 2020;35(1):160-170. Published online October 28, 2019
Background/Aims: Parathyroid hormone (PTH) is an important factor influencing immunologic dysfunction, but the effect of PTH level on infection-related outcomes remains unclear in incident dialysis.
Methods: We evaluated a multicenter prospective cohort study of 1,771 incident dialysis patients (1,..
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Hemato-oncology
Inflammatory markers as prognostic indicators in pancreatic cancer patients who underwent gemcitabine-based palliative chemotherapy
Hong Jun Kim, Suk-young Lee, Dae Sik Kim, Eun Joo Kang, Jung Sun Kim, Yoon Ji Choi, Sang Cheul Oh, Jae Hong Seo, Jun Suk Kim
Korean J Intern Med. 2020;35(1):171-184. Published online October 26, 2018
Background/Aims: Patients with pancreatic cancer (PC) generally have poor clinical outcomes. Early determination of their prognosis is crucial for developing a therapeutic strategy. Recently, various inflammatory markers have been validated as prognostic indicators for many cancers, including PC. Ho..
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Comparison of three risk stratification models for non-clear cell renal cell carcinoma patients treated with temsirolimus as first-line therapy
In Hee Lee, Byung Woog Kang, Jong Gwang Kim, Woo Kyun Bae, Myung Seo Ki, Inkeun Park, Jae-Cheol Jo, Jin Young Kim, Sung Ae Koh, Kyung Hee Lee, Yoon Young Cho, Hun Mo Ryoo, Sang Gyu Kwak, Jung Lim Lee, Sun Ah Lee
Korean J Intern Med. 2020;35(1):185-193. Published online October 12, 2018
Background/Aims: For metastatic renal cell carcinoma (RCC), various prognostic scoring systems have been developed. However, owing to the low prevalence of nonclear cell RCC, the three most commonly used tools were mainly developed based on patients with clear cell histology. Accordingly, this study..
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Real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenance
Hee Kyung Kim, Wonseok Kang, Dong Hyun Sinn, Joon Hyeok Lee, Won Seog Kim, Seok Jin Kim
Korean J Intern Med. 2020;35(1):194-204. Published online April 4, 2019
Background/Aims: Real-world data about the treatment outcomes of patients receiving rituximab-containing immunochemotherapy followed by rituximab maintenance are required to understand better the treatment for follicular lymphoma (FL).
Methods: A cross-sectional study analyzed FL patients who were ..
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Practice patterns of multidisciplinary team meetings in Korean cancer care and patient satisfaction with this approach
Chi Hoon Maeng, Hee Kyung Ahn, Sung Yong Oh, Seungtaek Lim, Bong-Seog Kim, Do Yeun Kim
Korean J Intern Med. 2020;35(1):205-214. Published online December 6, 2019
Background/Aims: The multidisciplinary team (MDT) approach is a cornerstone of clinical oncology. This study investigated the current state of MDT care, including patient satisfaction, in Korea.
Methods: We obtained the annual number of cancer patients who have received MDT care since 2014 from the..
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Infectious diseases
Clinical impact of healthcare-associated acquisition in cirrhotic patients with community-onset spontaneous bacterial peritonitis
Jungok Kim, Cheol-In Kang, Geum-Youn Gwak, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song
Korean J Intern Med. 2020;35(1):215-221. Published online March 5, 2018
Background/Aims: Healthcare-associated (HCA) infection is a recently suggested new category of community-onset infections. The implications of HCA infections in terms of diagnosis, treatment, and outcomes of spontaneous bacterial peritonitis (SBP) are not well understood. We sought to delineate the ..
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Allergy
Stability of extracts from pollens of allergenic importance in Korea
Kyoung Yong Jeong, Ji Eun Yuk, Jongsun Lee, Seok Woo Jang, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park
Korean J Intern Med. 2020;35(1):222-230. Published online September 20, 2019
Background/Aims: Accurate diagnosis and the effects of allergen-specific immunotherapy for pollinosis are greatly dependent on the potency and stability of the extract. This study aimed to examine factors, such as temperature and storage buffer composition, that affect the stability of allergen extr..
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Rheumatology
Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
Kichul Shin, Sung Soo Kim, Sang-Heon Lee, Seung-Jae Hong, Sung Jae Choi, Jung-Yoon Choe, Seung-Geun Lee, Hoon-Suk Cha, Eun Young Lee, Sung-Hwan Park, Jin-Wuk Hur, Sung Soo Na, Chang-Hee Suh, Min Wook So, Seung Won Choi, Dong-Hyuk Sheen, Won Park, Shin-Seok Lee, Wan Hee Ryu, Jin Seok Kim, Jung Soo Song, Hye Soon Lee, Seong Ho Kim, Dae-Hyun Yoo
Korean J Intern Med. 2020;35(1):231-239. Published online January 28, 2019
Background/Aims: The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. Methods: This was ..
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Clinical features and recurrent attack in gout patients according to serum urate levels during an acute attack
Jung Sun Lee, Oh Chan Kwon, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong
Korean J Intern Med. 2020;35(1):240-248. Published online January 28, 2019
Background/Aims: A substantial portion of gout patients have normal serum urate levels during an acute attack but data on the clinical characteristics and risk of recurrence compared with hyperuricemic patients are limited. Methods: In this retrospective cohort study, clinical features of normourice..
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| Images of interest |
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Jejunal diverticulosis
Tetsuya Ohira, Atsushi Iraha, Tetsu Kinjo, Akira Hokama, Jiro Fujita
Korean J Intern Med. 2020;35(1):249-249. Published online August 13, 2018
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Acute mitral valve dysfunction and cardiogenic shock due to escape of prosthetic mechanical leaflet
Mirae Lee, Su A Jo, Ik Hyun Park
Korean J Intern Med. 2020;35(1):250-251. Published online January 2, 2020
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Multidermatomal Herpes Zoster in immunocompromised patient
Keon Woo Park, Do Hyoung Lim, Soon Il Lee
Korean J Intern Med. 2020;35(1):252-253. Published online August 19, 2019
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Palmoplantar pustulosis secondary to anti-tumor necrosis factor therapy in a patient with ankylosing spondylitis
Jung Min Bae, Sung Hye Eun, Ki-Jo Kim
Korean J Intern Med. 2020;35(1):254-255. Published online October 18, 2019
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