| Reviews |
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Klotho and the Aging Process
Makoto Kuro-o
Korean J Intern Med. 2011;26(2):113-122. Published online June 1, 2011
The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the th..
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Current Status of Dialysis Therapy in Korea
Dong Chan Jin
Korean J Intern Med. 2011;26(2):123-131. Published online June 1, 2011
The number of patients with end-stage renal disease (ESRD) is rising very rapidly as the number of elderly and patients with diabetes increases in Korea. ESRD Registry Committee of the Korean Society of Nephrology (KSN) collected dialysis therapy data in Korea through an online registry program o..
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| Editorials |
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Tool for Guidance: Evidence-Based Recommendations for Managing Febrile Neutropenia
Andrew J. Ullmann
Korean J Intern Med. 2011;26(2):135-136. Published online June 1, 2011
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| Original Articles |
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Endoscopic Cryotherapy of Lung and Bronchial Tumors: A Systematic Review
Seon-Heui Lee, Won-Jung Choi, Sook-Whan Sung, Young-Kyoon Kim, Chi-Hong Kim, Jae-Il Zo, Kwang-Joo Park
Korean J Intern Med. 2011;26(2):137-144. Published online June 1, 2011
Background/AimsWe made a systematic review and evaluation of endoscopic cryotherapy of endobronchial tumors, investigating safety and efficacy. MethodsQualified studies regarding endoscopic cryotherapy of lung tumors were systemically evaluated ..
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Detection of Clopidogrel Hyporesponsiveness Using a Point-of-Care Assay and the Impact of Additional Cilostazol Administration after Coronary Stent Implantation in Diabetic Patients
Tae-Hyun Yang, Doo-Il Kim, Dong-Kie Kim, Jae-Sik Jang, Ung Kim, Sang-Hoon Seol, Dae-Kyeong Kim, Geu-Ru Hong, Jong-Seon Park, Dong-Gu Shin, Young-Jo Kim, Yun-Kyeong Cho, Chang-Wook Nam, Seung-Ho Hur, Kwon-Bae Kim, Dong-Soo Kim
Korean J Intern Med. 2011;26(2):145-152. Published online June 1, 2011
Background/AimsImpaired responsiveness to clopidogrel is common in patients with type 2 diabetes mellitus (DM). The aim of this study was to evaluate the clinical application of a point-of-care assay to detect impaired responsiveness to clopidogrel after coronary stent implant..
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Retrospective Comparison of Levofloxacin and Moxifloxacin on Multidrug-Resistant Tuberculosis Treatment Outcomes
Jinwoo Lee, Chang-Hoon Lee, Deog Kyeom Kim, Ho Il Yoon, Jae Yeol Kim, Sang-Min Lee, Seok-Chul Yang, Jae Ho Lee, Chul-Gyu Yoo, Choon-Taek Lee, Hee Soon Chung, Young Whan Kim, Sung Koo Han, Jae-Joon Yim
Korean J Intern Med. 2011;26(2):153-159. Published online June 1, 2011
Background/AimsTo compare the effect of levofloxacin and moxifloxacin on treatment outcomes among patients with multidrug-resistant tuberculosis (MDR-TB). MethodsA retrospective analysis of 171 patients with MDR-TB receiving either levofloxacin ..
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Outcome of Pandemic H1N1 Pneumonia: Clinical and Radiological Findings for Severity Assessment
Woo Hyun Cho, Yun Seong Kim, Doo Soo Jeon, Ji Eun Kim, Kun Il Kim, Hee Yun Seol, Ki Uk Kim, Hye Kyung Park, Min Ki Lee, Soon Kew Park, Yeon Joo Jeong
Korean J Intern Med. 2011;26(2):160-167. Published online June 1, 2011
Background/AimsPandemic influenza A (H1N1) virus infection presents with variable severity. However, little is known about clinical predictors of disease severity. We studied the clinical predictors of severe pandemic H1N1 pneumonia and their correlation with radiological find..
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Effects of D-003 (10 mg/day) on Bone Mineral Density of the Lumbar Spine and Femoral Neck in Postmenopausal Women: A Randomized, Double-Blinded Study
Alfredo Ceballos, Gladys Castaño, Sarahí Mendoza, Juan González, Rosa Mas, Lilia Fernández, José Illnait, Meilis Mesa, Rafael Gámez, Julio César Fernández, Ricardo Telles, Duany Marrero, Mainel Gómez Eng, Dalmer Ruiz, Yunaisi Jardines
Korean J Intern Med. 2011;26(2):168-178. Published online June 1, 2011
Background/AimsIncreased osteoclast activity is a pivotal finding in osteoporosis. This increase is mediated via the mevalonate-to-cholesterol pathway, which is involved in producing the intermediates required for osteoclast activity. D-003, a mixture of high molecular weight ..
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Diagnostic Value of a Chimeric TSH Receptor (Mc4)-Based Bioassay for Graves' Disease
Ji In Lee, Hye Won Jang, Soo Kyoung Kim, Joon Young Choi, Ji Young Kim, Kyu Yeon Hur, Jae Hyeon Kim, Yong-Ki Min, Jae Hoon Chung, Sun Wook Kim
Korean J Intern Med. 2011;26(2):179-186. Published online June 1, 2011
Background/AimsGraves' disease (GD) is caused by thyroid-stimulating hormone receptor (TSHR) and thyroid-stimulating immunoglobulin (TSI). We used a recently introduced, technically enhanced TSI bioassay to assess its diagnostic value and determine the cut-off in patients in h..
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Role of IL-1α in Cisplatin-Induced Acute Renal Failure in Mice
Jay-Wook Lee, Woo-Jin Nam, Min-Jee Han, Jung-Ho Shin, Jin-Gun Kim, Su-Hyun Kim, Hye-Ryoun Kim, Dong-Jin Oh
Korean J Intern Med. 2011;26(2):187-194. Published online June 1, 2011
Background/AimsFor unknown reasons, caspase-1 -/- mice, protected against cisplatin-induced acute renal failure (ARF), are deficient in interleukin (IL)-1α. We thus asked whether IL-1α deficiency underlies the mechanism of protection against cisplatin-induced ARF in these mic..
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Usefulness of C-Reactive Protein for Evaluating Clinical Outcomes in Cirrhotic Patients with Bacteremia
Young Eun Ha, Cheol-In Kang, Eun-Jeong Joo, Mi-Kyong Joung, Doo Ryeon Chung, Kyong Ran Peck, Nam Yong Lee, Jae-Hoon Song
Korean J Intern Med. 2011;26(2):195-200. Published online June 1, 2011
Background/AimsThe purpose of this study was to evaluate the value of initial C-reactive protein (CRP) as a predictor of clinical outcome and to investigate whether follow-up CRP measurement is useful for the prediction of the clinical outcome of bloodstream infections in pati..
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| Case Reports |
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Application of Helical Tomotherapy for Two Cases of Advanced Hepatocellular Carcinoma
Joon Sung Kim, Chan Ran You, Jeong Won Jang, Si-Hyun Bae, Jong Yong Choi, Seung Kew Yoon, Chul Seung Kay
Korean J Intern Med. 2011;26(2):201-206. Published online June 1, 2011
The role of radiotherapy in the treatment of hepatocellular carcinoma (HCC) has been limited to date, because the liver has a low tolerance to radiation. However, reconstructing tumors and surrounding organs via a three-dimensional conformal planning system can avoid excess radiotherapy exposure ..
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Primary Small Cell Carcinoma of the Lung Presenting with Breast and Skin Metastases
Fatih Altintoprak, Halil Fırat Baytekin, Canatan Tasdemir
Korean J Intern Med. 2011;26(2):207-209. Published online June 1, 2011
Cutaneous metastases originating from an internal cancer are relatively uncommon in clinical practice, and metastatic lesions to the breast are rarer than those to the skin. Skin metastases of lung cancer, which may be the first sign of the disease, usually indicate progressive disease and a poor..
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False-Positive Hypermetabolic Lesions on Post-Treatment PET-CT after Influenza Vaccination
Jeong-Eun Kim, Eun Kyoung Kim, Dae Ho Lee, Sang-We Kim, Cheolwon Suh, Jung-Shin Lee
Korean J Intern Med. 2011;26(2):210-212. Published online June 1, 2011
We report a case of a 59-year-old man with testicular germ cell tumor who showed new hypermetabolic lesions at the left axillary lymph nodes on a post-treatment positron emission tomography-computed tomography (PET-CT) scan. The hypermetabolic lesions were found to be caused by an influenza vacci..
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Complete Atrioventricular Block in Adult Sjögren's Syndrome with Anti-Ro Autoantibody
Myung Jun Sung, Sung-Hoon Park, Seong-Kyu Kim, Young-Soo Lee, Chul-Yeon Park, Jung-Yoon Choe
Korean J Intern Med. 2011;26(2):213-215. Published online June 1, 2011
Anti-Ro autoantibody is associated with Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), and neonatal lupus syndrome (i.e., congenital complete heart block in newborns). Generally, the adult atrioventricular (AV) node is believed to be relatively resistant to the scarring effects of..
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| Images of interest |
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A Case of Coarctation of the Aorta Diagnosed by Tardus-Parvus Renal Doppler Flow Patterns
Yun-Hwa Jung, Kwan-Wook Kim, Dae-Yoon Kim, Chul-Seung Lee
Korean J Intern Med. 2011;26(2):216-217. Published online June 1, 2011
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Ectopic Thyroid Nodule in Thyroglossal Duct
Ah-Young Shin, Seung-Hwan Lee, Won Sang Jung, Seung-Hyun Ko, Yu-Bae Ahn
Korean J Intern Med. 2011;26(2):218-219. Published online June 1, 2011
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| Guideline |
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Evidence-Based Guidelines for Empirical Therapy of Neutropenic Fever in Korea
Dong-Gun Lee, Sung-Han Kim, Soo Young Kim, Chung-Jong Kim, Wan Beom Park, Young Goo Song, Jung-Hyun Choi
Korean J Intern Med. 2011;26(2):220-252. Published online June 1, 2011
Neutrophils play an important role in immunological function. Neutropenic patients are vulnerable to infection, and except fever is present, inflammatory reactions are scarce in many cases. Additionally, because infections can worsen rapidly, early evaluation and treatments are especially importa..
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| Erratum |
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Errata
Korean J Intern Med. 2011;26(2):253-253. Published online June 1, 2011
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