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Hemato-oncology
Leukemic stem cell phenotype is associated with mutational profile in acute myeloid leukemia
Heejoo Han, Ja Min Byun, Dong-Yeop Shin, Sung-Soo Yoon, Youngil Koh, Junshik Hong, Inho Kim, Chansup Lee, Hyeonjoo Yoo, Hongseok Yun, Man Jin Kim, Sung Im Cho, Moon-Woo Seong, Sung Sup Park
Korean J Intern Med. 2021;36(2):401-412. Published online August 20, 2020
Background/Aims: Understanding leukemic stem cell (LSC) is important for acute myeloid leukemia (AML) treatment. However, association of LSC with patient prognosis and genetic information in AML patients is unclear.
Methods: Here we investigated the associations between genetic information and the ..
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Strong association between herpes simplex virus-1 and chemotherapy-induced oral mucositis in patients with hematologic malignancies
Junshik Hong, Hee-Kyung Park, Suhyun Park, Ahreum Lee, Yeon-Hee Lee, Dong-Yeop Shin, Youngil Koh, Ji-Yeob Choi, Sung-Soo Yoon, Youngnim Choi, Inho Kim
Korean J Intern Med. 2020;35(5):1188-1198. Published online September 9, 2019
Background/Aims: A link between oral cavity infections and chemotherapy-induced oral mucositis (CIOM) in patients with hematological malignancies (HMs) undergoing intensive chemotherapy (IC) or hematopoietic stem cell transplantation (HSCT) has been suggested. However, conclusive data are lacking, a..
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Rheumatology
Mutation of ten-eleven translocation-2 is associated with increased risk of autoimmune disease in patients with myelodysplastic syndrome
Yoon-Jeong Oh, Dong-Yeop Shin, Sang Mee Hwang, Sung-Min Kim, Kyongok Im, Hee Sue Park, Jung-Ah Kim, Yeong Wook Song, Ana Márquez, Javier Martín, Dong-Soon Lee, Jin Kyun Park
Korean J Intern Med. 2020;35(2):457-464. Published online October 25, 2019
Background/Aims: Myelodysplastic syndrome (MDS) is caused by genetic and epigenetic alteration of hematopoietic precursors and immune dysregulation. Approximately 20% of patients with MDS develop an autoimmune disease (AID). Here, we investigated whether particular genetic mutations are associated w..
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Hemato-oncology
Small RNA sequencing profiles of mir-181 and mir-221, the most relevant microRNAs in acute myeloid leukemia
Yun-Gyoo Lee, Inho Kim, Somi Oh, Dong-Yeop Shin, Youngil Koh, Keun-Wook Lee
Korean J Intern Med. 2019;34(1):178-183. Published online November 27, 2017
Background/Aims: To evaluate and select microRNAs relevant to acute myeloid leukemia (AML) pathogenesis, we analyzed differential microRNA expression by quantitative small RNA next-generation sequencing using duplicate marrow samples from individual AML patients.
Methods: For this study, we obtaine..
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Acute Lymphoblastic Leukemia in Elderly Patients: A Single Institution's Experience
Dong-Yeop Shin, Inho Kim, Ki-Hwan Kim, Younak Choi, Seung Hoon Beom, Yaewon Yang, Yoojoo Lim, Eunyoung Lee, June Koo Lee, Ji Yeon Kim, Hyun Kyung Kim, Sung-Soo Yoon, Dong Soon Lee, Seonyang Park, Byoung-Kook Kim
Korean J Intern Med. 2011;26(3):328-339. Published online September 13, 2011
Background/AimsWe investigated the clinical characteristics and prognosis of elderly patients with acute lymphoblastic leukemia (ALL). MethodsWe reviewed the clinical data, laboratory findings, bone marrow findings, and cytogenetic analysis of el..
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Efficacy and Safety of Hepatic Arterial Infusion of Fluorouracil with Leucovorin as Salvage Treatment for Refractory Liver Metastases from Colorectal Cancer
Hyun Jung Lee, Yoon Soo Lee, Keun-Wook Lee, So Yeon Kim, Chang Jin Yoon, Dong-Yeop Shin, Yun Gyoo Lee, Se Yeon Choi, Sung-Gwon Kang, Sung-Bum Kang, Jee Hyun Kim
Korean J Intern Med. 2011;26(1):82-88. Published online March 2, 2011
Background/AimsLimited options remain for patients with metastatic colorectal cancer (CRC) after failure of standard systemic chemotherapy. Readministration of chemotherapeutic agents by hepatic arterial infusion (HAI) has the rationale of providing higher concentrations of ch..
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