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Endocrinology-metabolism
Clinical features and signaling effects of RET D631Y variant multiple endocrine neoplasia type 2 (MEN2)
Ji-young Lee, Su Yeon Kim, Kwan Hoon Jo, Eun Yeong Mo, Eun Sook Kim, Hye Soo Kim, Je Ho Han, Sung-dae Moon
Korean J Intern Med. 2022;37(2):398-410. Published online December 15, 2021
Background/Aims: Germline mutations of the rearranged during transfection (RET) gene cause multiple endocrine neoplasia type 2 (MEN2). About 85% of RET mutations in MEN2 occur in codon Cys634. The RET D631Y mutation has recently been discovered, and we have studied its molecular expres..
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Clinical implications of anti-thyroglobulin antibody measurement before surgery in thyroid cancer
Kwanhoon Jo, Dong-Jun Lim
Korean J Intern Med. 2018;33(6):1050-1057. Published online October 30, 2018
Thyroglobulin antibody (TgAb) is a class G immunoglobulin and a conventional marker for thyroid autoimmunity. From a clinical perspective, TgAb is less useful than thyroid peroxidase antibodies for predicting thyroid dysfunction. However, TgAb is found more frequently in differentiated thyroid cance..
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Synchronous parathyroid carcinoma and papillary thyroid carcinoma in a patient with long-standing schizophrenia
Cho-Ok Baek, Ki Hoi Kim, Sun Kyung Song
Korean J Intern Med. 2017;32(6):1104-1107. Published online October 17, 2017
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Endocrinology-metabolism
Oncogenes, mitochondrial metabolism, and quality control in differentiated thyroid cancer
Hyon-Seung Yi, Joon Young Chang, Koon Soon Kim, Minho Shong
Korean J Intern Med. 2017;32(5):780-789. Published online August 22, 2017
Thyroid cancer is one of the most common malignancies of endocrine organs, and its incidence rate has increased steadily over the past several decades. Most differentiated thyroid tumors derived from thyroid epithelial cells exhibit slow-growing cancers, and patients with these tumors can achieve a ..
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Serum vitamin D3 levels are not associated with thyroid cancer prevalence in euthyroid subjects without autoimmune thyroid disease
Yun Mi Choi, Won Gu Kim, Tae Yong Kim, Sung Jin Bae, Hong-Kyu Kim, Eun Kyung Jang, Min Ji Jeon, Ji Min Han, Young Kee Shong, Won Bae Kim
Korean J Intern Med. 2017;32(1):102-108. Published online September 1, 2016
Background/Aims: Previous studies have suggested that elevated serum vitamin D levels might protect against thyroid cancer. Elevated serum thyroid stimulating hormone levels and autoimmune thyroid disease (AITD) are suggested to be thyroid cancer promoting factors but have not been well controlled i..
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The effect of 5-aminoimidazole-4-carboxamideribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells
Won Gu Kim, Hyun-Jeung Choi, Tae Yong Kim, Young Kee Shong, Won Bae Kim
Korean J Intern Med. 2014;29(4):474-481. Published online June 27, 2014
Background/Aims: 5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a cellular energy sensor that monitors intracellular AMP/adenosine triphosphate (ATP) ratios and is a key regulator of the proliferation and survival of diverse malignant cell types. In the present study, we inves..
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Distant subcutaneous recurrence of a parathyroid carcinoma: abnormal uptakes in the 99mTc-sestamibi scan and 18F-FDG PET/CT imaging
Sang Soo Kim, Yun Kyung Jeon, Soo Hyung Lee, Bo Hyun Kim, Seong Jang Kim, Yong Ki Kim, In Ju Kim
Korean J Intern Med. 2014;29(3):383-387. Published online April 29, 2014
We report a rare case of distant subcutaneous parathyroid carcinoma recurrence. A 50‑year-old woman was referred to our hospital because of sustained hypercalcemia despite surgical removal of a parathyroid carcinoma. A focal uptake in the upper mediastinal area was detected in a 99mTc-s..
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DNA Methylation of RUNX3 in Papillary Thyroid Cancer
Hee Ja Ko, Bo Yeon Kim, Chan Hee Jung, Sung Wan Chun, Ji Oh Mok, Yeo Joo Kim, Hyeong Kyu Park, Chul Hee Kim, Sang Jin Kim, Dong Won Byun, Kyo Il Suh, Myung Hi Yoo, Sung Gu Kang
Korean J Intern Med. 2012;27(4):407-410. Published online November 27, 2012
Background/AimsThe relationship between Runt-related transcription factor 3 (RUNX3) gene inactivation and various solid tumors has been reported; however, little information is available about RUNX3 in thyroid cancers. Met.. </div>
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<a class="artiletitle" href="/journal/view.php?number=162595" onmouseover="showAbstract('162595' );" onmouseout="hideAbstract('162595' );"><b><font>Parathyroid Carcinoma Presenting as a Hyperparathyroid Crisis</font></b></a>
<div style="padding-top:2px;padding-left:0px" class="article_authors">Alice Hyun-Kyung Tan, Hee Kyung Kim, Mi Yeon Kim, Young Lyun Oh, Jee Soo Kim, Jae Hoon Chung, Sun Wook Kim</div>
<div style="padding-top:2px;padding-left:0px" class="article_issue">
<em>Korean J Intern Med.</em> 2012;27(2):229-231. Published online May 31, 2012 </div>
<div class="doi">DOI: <a href="https://doi.org/10.3904/kjim.2012.27.2.229"><font class="doi">https://doi.org/10.3904/kjim.2012.27.2.229</font></a>
<a href="/journal/CitedByRenew.php?number=162595" onclick="window.open(this.href, 'CrossRef Citedby', 'width=800,height=800,scrollbars=yes');return false;" style="color:#DD434F;font-size:10pt;"> Crossref 5</a>
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<a href='/journal/view.php?number=162595' style='text-decoration:underline;color:#2046f8'><img src='/image/button/fulltext.gif' alt='Full Text' /></a> <a href='/journal/view.php?viewtype=pubreader&number=162595' style='text-decoration:underline;color:#2046f8'><img src='/image/button/pubreader.gif' alt='PubReader' /></a> <a style='cursor: pointer;' onclick='journal_download("epub", "162595", "path=L2hvbWUvdmlydHVhbC9rYWltL2pvdXJuYWwvdXBsb2FkL2VwdWIva2ppbS0yNy0yMjkuZXB1Yg==&filename=a2ppbS0yNy0yMjkuZXB1Yg==")'><img src='/image/button/epub.gif' alt='ePub' /></a> <a style='cursor: pointer;' onclick='journal_download("pdf", "162595", "kjim-27-229.pdf")'><img src='/image/button/pdf.gif' alt='PDF' /></a> </div>
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<a class="artiletitle" href="/journal/view.php?number=162459" onmouseover="showAbstract('162459' );" onmouseout="hideAbstract('162459' );"><b><font>Anaplastic Thyroid Carcinoma Initially Presented with Abdominal Cutaneous Mass and Hyperthyroidism</font></b></a>
<div style="padding-top:2px;padding-left:0px" class="article_authors">Kyu-Hyoung Lim, Keun-Wook Lee, Jee Hyun Kim, So Yeon Park, Sung-Hee Choi, Jong Seok Lee</div>
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<em>Korean J Intern Med.</em> 2010;25(4):450-453. Published online November 27, 2010 </div>
<div class="doi">DOI: <a href="https://doi.org/10.3904/kjim.2010.25.4.450"><font class="doi">https://doi.org/10.3904/kjim.2010.25.4.450</font></a>
<a href="/journal/CitedByRenew.php?number=162459" onclick="window.open(this.href, 'CrossRef Citedby', 'width=800,height=800,scrollbars=yes');return false;" style="color:#DD434F;font-size:10pt;"> Crossref 6</a>
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<a href='/journal/view.php?number=162459' style='text-decoration:underline;color:#2046f8'><img src='/image/button/fulltext.gif' alt='Full Text' /></a> <a href='/journal/view.php?viewtype=pubreader&number=162459' style='text-decoration:underline;color:#2046f8'><img src='/image/button/pubreader.gif' alt='PubReader' /></a> <a style='cursor: pointer;' onclick='journal_download("epub", "162459", "path=L2hvbWUvdmlydHVhbC9rYWltL2pvdXJuYWwvdXBsb2FkL2VwdWIva2ppbS0yNS00NTAuZXB1Yg==&filename=a2ppbS0yNS00NTAuZXB1Yg==")'><img src='/image/button/epub.gif' alt='ePub' /></a> <a style='cursor: pointer;' onclick='journal_download("pdf", "162459", "kjim-25-450.pdf")'><img src='/image/button/pdf.gif' alt='PDF' /></a> </div>
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<p>A 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter, which she had for 1 month. About 1 week earlier, the patient had also perceived a mass in the neck area. Computed tomography revealed huge thyroid and periumbilical masses. The thyroid hor.. </div>
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<a class="artiletitle" href="/journal/view.php?number=162453" onmouseover="showAbstract('162453' );" onmouseout="hideAbstract('162453' );"><b><font>Clinical Significance of Observation without Repeated Radioiodine Therapy in Differentiated Thyroid Carcinoma Patients with Positive Surveillance Whole-Body Scans and Negative Thyroglobulin</font></b></a>
<div style="padding-top:2px;padding-left:0px" class="article_authors">Dong-Jun Lim, Joo Hyun O, Min-Hee Kim, Ji-Hyun Kim, Hyuk-Sang Kwon, Sung-Hoon Kim, Moo-Il Kang, Bong-Yun Cha, Kwang-Woo Lee, Ho-Young Son</div>
<div style="padding-top:2px;padding-left:0px" class="article_issue">
<em>Korean J Intern Med.</em> 2010;25(4):408-414. Published online November 27, 2010 </div>
<div class="doi">DOI: <a href="https://doi.org/10.3904/kjim.2010.25.4.408"><font class="doi">https://doi.org/10.3904/kjim.2010.25.4.408</font></a>
<a href="/journal/CitedByRenew.php?number=162453" onclick="window.open(this.href, 'CrossRef Citedby', 'width=800,height=800,scrollbars=yes');return false;" style="color:#DD434F;font-size:10pt;"> Crossref 15</a>
</div>
<div class="etc" style="padding-top:5px;text-align: right;">
<a href='/journal/view.php?number=162453' style='text-decoration:underline;color:#2046f8'><img src='/image/button/fulltext.gif' alt='Full Text' /></a> <a href='/journal/view.php?viewtype=pubreader&number=162453' style='text-decoration:underline;color:#2046f8'><img src='/image/button/pubreader.gif' alt='PubReader' /></a> <a style='cursor: pointer;' onclick='journal_download("epub", "162453", "path=L2hvbWUvdmlydHVhbC9rYWltL2pvdXJuYWwvdXBsb2FkL2VwdWIva2ppbS0yNS00MDguZXB1Yg==&filename=a2ppbS0yNS00MDguZXB1Yg==")'><img src='/image/button/epub.gif' alt='ePub' /></a> <a style='cursor: pointer;' onclick='journal_download("pdf", "162453", "kjim-25-408.pdf")'><img src='/image/button/pdf.gif' alt='PDF' /></a> </div>
<div id="162453" style="display:none;padding-top:10px;padding-left:0px; color:#7b7b7b">
<sec><title>Background/AimsCurrently, there is no consensus on the necessity of repeated radioiodine therapy (RAI) in patients who show iodine uptake in the thyroid bed on a diagnostic whole-body scan (DxWBS) despite undetectable thyroglobulin (Tg) levels after remnant ablation. The prese..
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Ultrasonographic Features of Papillary Thyroid Carcinoma in Patients with Graves' Disease
Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Korean J Intern Med. 2010;25(1):71-76. Published online February 26, 2010
Background/AimsTo characterize ultrasonographic findings in papillary thyroid carcinoma (PTC) combined with Graves' disease. MethodsMedical records and ultrasonographic findings of 1,013 patients with Graves' disease and 3,380 patients without G..
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