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Hemato-oncology
Identification and overcoming rituximab resistance in diffuse large B-cell lymphoma using next-generation sequencing
Min Ji Jeon, Eun Sang Yu, Chul Won Choi, Dae Sik Kim
Korean J Intern Med. 2023;38(6):893-902. Published online August 21, 2023
Background/Aims: Although rituximab, an antiCD20 monoclonal antibody, has dramatically improved the clinical outcomes of diffuse large B-cell lymphoma, rituximab resistance remains a challenge.
Methods: We developed a rituximab-resistant cell line (RRCL) by sequential exposure to gradually increasi..
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Gastroenterology
Ten-day tegoprazan-based concomitant therapy as a first-line treatment for Helicobacter pylori eradication
Yong Hwan Kwon, Seong Woo Jeon, Su Youn Nam, Dong Wook Lee, Ji Hey Park, Hui Jin Bae
Korean J Intern Med. 2023;38(4):493-503. Published online June 28, 2023
Background/Aims: Tegoprazan, a novel potassium-competitive acid blocker, has shown rapid action and gastric acid inhibition. In this study, we evaluated the efficacy of a tegoprazan-based, nonbismuth-containing quadruple (concomitant) therapy for the primary eradication of Helicobacter pylori..
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Urgent need for novel antibiotics in Republic of Korea to combat multidrug-resistant bacteria
Hyo-Jin Lee, Dong-Gun Lee
Korean J Intern Med. 2022;37(2):271-280. Published online February 28, 2022
Multidrug resistance in bacteria is an important issue and is increasing in frequency worldwide because of the limitations of therapeutic agents. From 2010 to 2019, 14 new systemic antibiotics received regulatory approval in the United States. However, few new antibiotics have been introduced in Rep..
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Geriatrics
Four-year changes in central fatness, risk of diabetes, and metabolic control in older adults: a cohort study with mediation analysis
Xue Cai, Dan Luo, Shuling Liu, Ruxue Li, Yanhui Lu, Mingzi Li, Shanhu Qiu
Korean J Intern Med. 2022;37(1):230-240. Published online December 16, 2021
Background/Aims: Older adults are vulnerable to central obesity, while the association of changes in central fatness with risk of diabetes and metabolic control has not been investigated among this particular population. This study was aimed to address these issues.
Methods: A total of 1,815 adults..
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Endocrinology-metabolism
Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey
Jeonghoon Ha, Jeongmin Lee, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo-Il Kang, Min-Hee Kim
Korean J Intern Med. 2021;36(Suppl 1):S170-S179. Published online June 9, 2020
Background/Aims: Thyroid hormones are involved in wide range of glucose metabolism functions. Overt thyroid dysfunctions are related to altered glucose homeostasis. However, it is not conclusive as to whether subtle changes in thyroid hormones within normal ranges can induce alterations in glucose h..
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Gastroenterology
Impact of previous metronidazole exposure on metronidazole-based second-line quadruple therapy for Helicobacter pylori infection
Gil Ho Lee, Kee Myung Lee, Sung Jae Shin, Joon Koo Kang, Choong-Kyun Noh, Jin Hong Kim, Sun Gyo Lim
Korean J Intern Med. 2020;35(5):1094-1103. Published online July 31, 2020
Background/Aims: The negative effects on the eradication success of Helicobacter pylori infection after previous exposure to macrolides, including clarithromycin on clarithromycin-based first-line therapy have been demonstrated. However, whether this is true for metronidazole-based second-lin..
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Infectious diseases
Cancer patients with neutropenic septic shock: etiology and antimicrobial resistance
Sung Min Jung, Youn Jung Kim, Seung Mok Ryoo, Chang Hwan Sohn, Dong Woo Seo, Kyoung Soo Lim, Won Young Kim
Korean J Intern Med. 2020;35(4):979-987. Published online October 28, 2019
Background/Aims: Among patients with febrile neutropenia that developed after chemotherapy, high-risk patients, such as those having clinical instability or Multinational Association of Supportive Care in Cancer score of < 21, require hospitalization for intravenous empiric antibiotic therapy. Mono..
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Pulmonology
Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma
Hea Yon Lee, Hwa Young Lee, Jung Hur, Hye Seon Kang, Joon Young Choi, Chin Kook Rhee, Ji Young Kang, Young Kyoon Kim, Sook Young Lee
Korean J Intern Med. 2020;35(3):619-629. Published online March 19, 2020
Background/Aims: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that plays a key role in Th2-mediated inflammation, both directly by promoting the proliferation of naïve CD4 Th2 cells, and indirectly by activating dendritic cells (DCs). TSLP-activated DCs induce the exp..
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Infectious diseases
Reevaluation of the impact of methicillin-resistance on outcomes in patients with Staphylococcus aureus bacteremia and endocarditis
Eun-Jeong Joo, Dong Ah Park, Cheol-In Kang, Doo Ryeon Chung, Jae-Hoon Song, Sang Moo Lee, Kyong Ran Peck
Korean J Intern Med. 2019;34(6):1347-1362. Published online January 20, 2018
Background/Aims: Methicillin-resistant Staphylococcus aureus (MRSA) is highly prevalent in hospitals, and has recently emerged in the community. The impact of methicillin-resistance on mortality and medical costs for patients with S. aureus bacteremia (SAB) requires reevaluation.
Meth..
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Nephrology
Effects of aspirin resistance and mean platelet volume on vascular access failure in hemodialysis patients
AJin Cho, Myung Jin Choi, Young-Ki Lee, Han Chae Hoon, Ja-Ryong Koo, Jong-Woo Yoon, Jung-Woo Noh
Korean J Intern Med. 2019;34(6):1304-1312. Published online July 23, 2018
Background/Aims: Maintaining the patency of vascular access (VA) in hemodialysis (HD) patients is important and can be life-saving. We investigated the effects of aspirin resistance and mean platelet volume (MPV) on VA failure in HD patients.
Methods: We enrolled 163 patients on maintenance HD. VA ..
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Pulmonology
Clinical efficacy of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in patients with multidrug-resistant bacteremia: a single-center study in Korea
Jeongha Mok, Eun-Jung Jo, Jung Seop Eom, Mi-Hyun Kim, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee, Kwangha Lee
Korean J Intern Med. 2019;34(5):1058-1067. Published online May 13, 2019
Background/Aims: Matrix-assisted laser desorption/ionization time-of-f light mass spectrometry (MALDI-TOF MS) is a new diagnostic tool for microorganism identification. The clinical usefulness of this approach has not been widely examined in Korea. This retrospective pre–post-intervention quasi-ex..
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Gastroenterology
Clarithromycin resistance and female gender affect Helicobacter pylori eradication failure in chronic gastritis
Young Woon Chang, Weon Jin Ko, Chi Hyuk Oh, Yoo Min Park, Shin Ju Oh, Jung Rock Moon, Jun-Hyung Cho, Jung-Wook Kim, Jae-Young Jang
Korean J Intern Med. 2019;34(5):1022-1029. Published online June 14, 2018
Background/Aims: The eradication rate of the first-line triple therapy (a proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has gradually decreased in Korea. We evaluated whether clinical parameters, clarithromycin resistance, and CYP2C19 genotype can affect t..
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Pulmonology
Trend of multidrug and fluoroquinolone resistance in Mycobacterium tuberculosis isolates from 2010 to 2014 in Korea: a multicenter study
Hyeonseok Kim, Jeong Ha Mok, Bohyoung Kang, Taehoon Lee, Hyun-Kyung Lee, Hang Jea Jang, Yu Ji Cho, Doosoo Jeon
Korean J Intern Med. 2019;34(2):344-352. Published online July 27, 2018
Background/Aims: This study was conducted to evaluate the recent prevalence and trend of anti-tuberculosis (TB) drug resistance with a focus on multidrug-resistance (MDR) and fluoroquinolone resistance in South Korea.
Methods: We retrospectively reviewed the drug susceptibility testing results of c..
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Rheumatology
Insulin resistance is an independent predictor of erectile dysfunction in patients with gout
Ji Hun Kim, Min Kyung Chung, Jin Young Kang, Jung Hee Koh, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Sung-Hwan Park
Korean J Intern Med. 2019;34(1):202-209. Published online October 12, 2017
Background/Aims: Gout is associated with metabolic disorders that are important risk factors for cardiovascular disease and erectile dysfunction (ED). We aimed to identify independent predictors of ED in patients with gout.
Methods: From August 2014 to August 2015, male outpatients who were being t..
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Infectious diseases
Management of carbapenem-resistant Acinetobacter baumannii epidemic in an intensive care unit using multifaceted intervention strategy
Jeongmin Hong, Ok Jeom Jang, Mi Hui Bak, Eun Hwa Baek, Ki-Ho Park, Sun In Hong, Oh-Hyun Cho, In-Gyu Bae
Korean J Intern Med. 2018;33(5):1000-1007. Published online November 27, 2017
Background/Aims: We evaluated the effects of a multifaceted intervention for controlling a carbapenem-resistant Acinetobacter baumannii (CRAB) epidemic in an intensive care unit (ICU) with no restrictions on carbapenem use.
Methods: This study was conducted in a medical ICU between April 201..
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Rheumatology
Metabolic syndrome: prevalence and risk factors in Korean gout patients
Jae Hyun Jung, Gwan Gyu Song, Jong Dae Ji, Young Ho Lee, Jae-Hoon Kim, Young Ho Seo, Sung Jae Choi
Korean J Intern Med. 2018;33(4):815-822. Published online October 12, 2016
Background/Aims: We performed this study to investigate associations between metabolic syndrome, chronic kidney disease (CKD), and gout.
Methods: We reviewed the medical records of 151 patients with gout at the Department of Rheumatology in Korea University Ansan Hospital. The following measures we..
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Infectious diseases
Changing trends in clinical characteristics and antibiotic susceptibility of Klebsiella pneumoniae bacteremia
Miri Hyun, Chang In Noh, Seong Yeol Ryu, Hyun Ah Kim
Korean J Intern Med. 2018;33(3):595-603. Published online November 10, 2017
Background/Aims: Klebsiella pneumoniae is second most common organism of gram-negative bacteremia in Korea and one of the most common cause of urinary tract infection, and intra-abdominal infection.
Methods: We compared clinical and microbiological characteristics about K. pneumoniae ..
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Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea
Young Ah Kim, Yoon Soo Park
Korean J Intern Med. 2018;33(2):247-255. Published online February 27, 2018
Antimicrobial resistance is becoming one of the greatest challenges to public health worldwide. Infections by antimicrobial-resistant organisms could result in the failure of treatment, increased medical costs, prolonged hospital stays, and an increased socioeconomic burden. Antimicrobial usage in K..
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Risk factors and molecular epidemiology of community-onset, multidrug resistance extended-spectrum β-lactamase-producing Escherichia coli infections
So Yeon Park, Cheol-In Kang, Yu Mi Wi, Doo Ryeon Chung, Kyong Ran Peck, Nam-Yong Lee, Jae-Hoon Song
Korean J Intern Med. 2017;32(1):146-157. Published online April 20, 2016
Background/Aims: Although multidrug resistance (MDR) among extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) poses significant therapeutic challenges, little is known regarding the risk factors and epidemiology of community-onset MDR‑ESBL‑EC infections. We performed this study t..
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Hemato-oncology
Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
Dae Sik Kim, Yoo Jin Na, Myoung Hee Kang, Soo-Young Yoon, Chul Won Choi
Korean J Intern Med. 2016;31(2):357-366. Published online February 15, 2016
Background/Aims: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed, and a substantial number of patients need alternative treatment ..
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