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Cardiology
Clinical efficacy of angiotensin receptor-neprilysin inhibitor in de novo heart failure with reduced ejection fraction
Su Yeong Park, Min Gyu Kong, Inki Moon, Hyun Woo Park, Hyung-Oh Choi, Hye Sun Seo, Yoon Haeng Cho, Nae-Hee Lee, Kwan Yong Lee, Ho-Jun Jang, Je Sang Kim, Ik Jun Choi, Jon Suh
Korean J Intern Med. 2023;38(5):692-703. Published online August 31, 2023
Background/Aims: We aimed to analyze the efficacy of angiotensin receptor-neprilysin inhibitor (ARNI) by the disease course of heart failure (HF).
Methods: We evaluated 227 patients with HF in a multi-center retrospective cohort that included those with left ventricular ejection fraction (LVEF) ≤..
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Left ventricular response after cardiac resynchronization therapy is related to early left atrial volume reduction
In-Jeong Cho, Jae-Sun Uhm, Jaewon Oh, Jong-Ho Nam, Hee Tae Yu, Taehoon Kim, Boyoung Joung, Seok-Min Kang
Korean J Intern Med. 2020;35(5):1125-1135. Published online February 6, 2020
Background/Aims: The current study aimed to elucidate a time-course change in left atrial volume after cardiac resynchronization therapy (CRT) and to verify factors associated with left atrial volume reduction (LAVR) and its prognostic implications.
Methods: The records of 97 patients were retrospe..
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Allergy
Different anti-remodeling effect of nilotinib and fluticasone in a chronic asthma model
Hye Seon Kang, Chin Kook Rhee, Hea Yon Lee, Hyoung Kyu Yoon, Soon Seok Kwon, Sook Young Lee
Korean J Intern Med. 2016;31(6):1150-1158. Published online October 20, 2016
Background/Aims: Inhaled corticosteroids are the most effective treatment currently available for asthma, but their beneficial effect against airway remodeling is limited. The tyrosine kinase inhibitor nilotinib has inhibitory activity against c-kit and the platelet-derived growth factor receptor. W..
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Pulmonology
Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma
Hwa Young Lee, Chin Kook Rhee, Ji Young Kang, Chan Kwon Park, Sook Young Lee, Soon Suk Kwon, Young Kyoon Kim, Hyoung Kyu Yoon
Korean J Intern Med. 2016;31(1):89-97. Published online December 28, 2015
Background/Aims: Asthma is characterized by airway hyperresponsiveness, inflammation, and remodeling. Peroxisome proliferator-activated receptors have been reported to regulate inflammatory responses in many cells. In this study, we examined the effects of intranasal rosiglitazone on airway remodeli..
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Cardiology
Interatrial septal thickness as a marker of structural and functional remodeling of the left atrium in patients with atrial fibrillation
Hong Euy Lim, Jin Oh Na, Sung Il Im, Cheol Ung Choi, Seong Hwan Kim, Jin Won Kim, Eung Ju Kim, Seong Woo Han, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Chun Hwang
Korean J Intern Med. 2015;30(6):808-820. Published online October 30, 2015
Background/Aims: There have been reports that interatrial septal (IAS) thickness is increased in patients with atrial fibrillation (AF). This study was performed to investigate whether IAS thickness determined by transthoracic echocardiography (TTE) represents the amount of left atrium (LA) structur..
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Rheumatology
Early effects of tumor necrosis factor inhibition on bone homeostasis after soluble tumor necrosis factor receptor use
Mie Jin Lim, Seong Ryul Kwon, Kowoon Joo, Min Jung Son, Shin-Goo Park, Won Park
Korean J Intern Med. 2014;29(6):807-813. Published online October 31, 2014
Background/Aims: Our aim was to assess whether short-term treatment with soluble tumor necrosis factor (TNF) receptor affects circulating markers of bone metabolism in rheumatoid arthritis (RA) patients.
Methods: Thirty-three active RA patients, treated with oral disease-modifying antirheumatic dru..
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Cardiology
Effect of anemia correction on left ventricular structure and filling pressure in anemic patients without overt heart disease
In-Jeong Cho, Yeung Chul Mun, Ki Hwan Kwon, Gil Ja Shin
Korean J Intern Med. 2014;29(4):445-453. Published online June 27, 2014
Background/Aims: There are few data on the effects of low hemoglobin levels on the left ventricle (LV) in patients without heart disease. The objective of this study was to document changes in the echocardiographic variables of LV structure and function after the correction of anemia without signif..
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Effects of D-003 (10 mg/day) on Bone Mineral Density of the Lumbar Spine and Femoral Neck in Postmenopausal Women: A Randomized, Double-Blinded Study
Alfredo Ceballos, Gladys Castaño, Sarahí Mendoza, Juan González, Rosa Mas, Lilia Fernández, José Illnait, Meilis Mesa, Rafael Gámez, Julio César Fernández, Ricardo Telles, Duany Marrero, Mainel Gómez Eng, Dalmer Ruiz, Yunaisi Jardines
Korean J Intern Med. 2011;26(2):168-178. Published online June 1, 2011
Background/AimsIncreased osteoclast activity is a pivotal finding in osteoporosis. This increase is mediated via the mevalonate-to-cholesterol pathway, which is involved in producing the intermediates required for osteoclast activity. D-003, a mixture of high molecular weight ..
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Remodeling of Ion Channel Expression in Patients with Chronic Atrial Fibrillation and Mitral Valvular Heart Disease
Seil Oh, Ki-Bong Kim, Hyuk Ahn, Hyun-Ju Cho, Yun-Shik Choi
Korean J Intern Med. 2010;25(4):377-385. Published online November 27, 2010
Background/AimsUnderlying cardiac pathology and atrial fibrillation (AF) affect the molecular remodeling of ion channels in the atria. Changes in the expression of these molecules have not been demonstrated in Korean patients with mitral valvular heart disease. Thus, the purp..
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