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Geriatrics
Four-year changes in central fatness, risk of diabetes, and metabolic control in older adults: a cohort study with mediation analysis
Xue Cai, Dan Luo, Shuling Liu, Ruxue Li, Yanhui Lu, Mingzi Li, Shanhu Qiu
Korean J Intern Med. 2022;37(1):230-240. Published online December 16, 2021
Background/Aims: Older adults are vulnerable to central obesity, while the association of changes in central fatness with risk of diabetes and metabolic control has not been investigated among this particular population. This study was aimed to address these issues.
Methods: A total of 1,815 adults..
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Endocrinology-metabolism
Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey
Jeonghoon Ha, Jeongmin Lee, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo-Il Kang, Min-Hee Kim
Korean J Intern Med. 2021;36(Suppl 1):S170-S179. Published online June 9, 2020
Background/Aims: Thyroid hormones are involved in wide range of glucose metabolism functions. Overt thyroid dysfunctions are related to altered glucose homeostasis. However, it is not conclusive as to whether subtle changes in thyroid hormones within normal ranges can induce alterations in glucose h..
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Nephrology
Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 as biomarkers of patients with established acute kidney injury
Won Yong Cho, Sung Yoon Lim, Ji Hyun Yang, Se Won Oh, Myung-Gyu Kim, Sang-Kyung Jo
Korean J Intern Med. 2020;35(3):662-671. Published online December 23, 2019
Background/Aims: Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been recently discovered and validated as sensitive biomarkers that can predict stage 2 or 3 acute kidney injury (AKI) development in high-risk patients. We aimed ..
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Endocrinology-metabolism
Higher glucagon-to-insulin ratio is associated with elevated glycated hemoglobin levels in type 2 diabetes patients
Minyoung Lee, Minkyung Kim, Jong Suk Park, Sangbae Lee, Jihong You, Chul Woo Ahn, Kyung Rae Kim, Shinae Kang
Korean J Intern Med. 2019;34(5):1068-1077. Published online September 8, 2017
Background/Aims: The importance of α-cell dysfunction in the pathogenesis of type 2 diabetes has re-emerged recently. However, data on whether relative glucagon excess is present in clinical settings are scarce. We aimed to investigate associations between glucagon-to-insulin ratio and various meta..
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Rheumatology
Insulin resistance is an independent predictor of erectile dysfunction in patients with gout
Ji Hun Kim, Min Kyung Chung, Jin Young Kang, Jung Hee Koh, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Sung-Hwan Park
Korean J Intern Med. 2019;34(1):202-209. Published online October 12, 2017
Background/Aims: Gout is associated with metabolic disorders that are important risk factors for cardiovascular disease and erectile dysfunction (ED). We aimed to identify independent predictors of ED in patients with gout.
Methods: From August 2014 to August 2015, male outpatients who were being t..
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Metabolic syndrome: prevalence and risk factors in Korean gout patients
Jae Hyun Jung, Gwan Gyu Song, Jong Dae Ji, Young Ho Lee, Jae-Hoon Kim, Young Ho Seo, Sung Jae Choi
Korean J Intern Med. 2018;33(4):815-822. Published online October 12, 2016
Background/Aims: We performed this study to investigate associations between metabolic syndrome, chronic kidney disease (CKD), and gout.
Methods: We reviewed the medical records of 151 patients with gout at the Department of Rheumatology in Korea University Ansan Hospital. The following measures we..
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Endocrinology-metabolism
Insulin therapy for adult patients with type 2 diabetes mellitus: a position statement of the Korean Diabetes Association, 2017
Byung-Wan Lee, Jin Hwa Kim, Seung-Hyun Ko, Kyu Yeon Hur, Nan-Hee Kim, Sang Youl Rhee, Hyun Jin Kim, Min Kyong Moon, Seok-O Park, Kyung Mook Choi; on behalf of the Committee of Clinical Practice Guideline of Korean Diabetes Association
Korean J Intern Med. 2017;32(6):967-973. Published online October 23, 2017
The Korean Diabetes Association (KDA) has regularly updated its Clinical Practice Guidelines. In 2017, the KDA published a position statement on the use of antihyperglycemic agents for patients with type 2 diabetes mellitus (T2DM). Growing evidence from new multinational clinical trials using novel ..
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Antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus 2017: a position statement of the Korean Diabetes Association
Seung-Hyun Ko, Kyu Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim; Committee of Clinical Practice Guideline of Korean Diabetes Association
Korean J Intern Med. 2017;32(6):947-958. Published online October 23, 2017
In 2017, the Korean Diabetes Association (KDA) published a position statement on the use of antihyperglycemic agents for patients with type 2 diabetes mellitus (T2DM). The KDA regularly updates its Clinical Practice Guidelines, but since the last update in 2015, many results from clinical trials hav..
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The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes
Ohk-Hyun Ryu, Wankyo Chung, Sungwha Lee, Kyung-Soon Hong, Moon-Gi Choi, Hyung Joon Yoo
Korean J Intern Med. 2014;29(5):620-629. Published online August 28, 2014
Background/Aims: Recent epidemiological studies revealed a striking inverse relationship between vitamin D levels, glucose intolerance/insulin resistance (IR), and cardiovascular disease. However, few interventional studies have evaluated the effect of vitamin D supplementation on cardiovascular ris..
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Measurement of antioxidant capacity using the biological antioxidant potential test and its role as a predictive marker of metabolic syndrome
Jung Hee Kim, Hyun Wook Baik, Yeong Sook Yoon, Hyo Jee Joung, Ju Sang Park, Sang Jong Park, Eun Jeong Jang, Sang Woon Park, Sang Jung Kim, Mi Jeoung Kim, Dong Ok Jeon, Hyo Jin Cho, Sang Jin Lee, Sung Gyu Im, Sun Kyung Jang
Korean J Intern Med. 2014;29(1):31-39. Published online January 2, 2014
Background/Aims: Oxidative stress increases the risk of cardiovascular complications
of metabolic syndrome (MetS). This study was conducted to examine the
difference in antioxidant capacity according to the presence of MetS, and to characterize
the association between antioxidant capacity and Me..
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Adipokines, insulin-like growth factor binding protein-3 levels, and insulin sensitivity in women with polycystic ovary syndrome
Hyejin Lee, Jee-Young Oh, Yeon-Ah Sung
Korean J Intern Med. 2013;28(4):456-463. Published online July 1, 2013
Background/AimsMany women with polycystic ovary syndrome (PCOS) exhibit insulin resistance. Adipose tissue plays an important role in insulin resistance, and adipokines including tumor necrosis factor (TNF)-α and adiponectin are altered in PCOS. Insulin-like growth factor bin..
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Gastroenterology
Effects of D-002, a mixture of high molecular weight beeswax alcohols, on patients with nonalcoholic fatty liver disease
José Illnait, Iván Rodríguez, Sarahí Mendoza, Yolanda Fernández, Rosa Mas, Mirtha Miranda, Jesús Piñera, Julio César Fernández, Meilis Mesa, Lilia Fernández, Daisy Carbajal, Rafael Gámez
Korean J Intern Med. 2013;28(4):439-448. Published online July 1, 2013
Background/AimsNonalcoholic fatty liver disease (NAFLD) is intimately related to insulin resistance and ranges from a benign course to liver fibrosis and cirrhosis. NAFLD management mainly involves dietary modification and weight loss. Although no fully successful pharmacologi..
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Endocrinology-metabolism
Low glibenclamide concentrations affect endoplasmic reticulum stress in INS-1 cells under glucotoxic or glucolipotoxic conditions
Min Jeong Kwon, Hye Suk Chung, Chang Shin Yoon, Eun Ju Lee, Tae Kyun Kim, Soon Hee Lee, Kyung Soo Ko, Byoung Doo Rhee, Mi Kyung Kim, Jeong Hyun Park
Korean J Intern Med. 2013;28(3):339-346. Published online May 1, 2013
Background/Aimsβ-Cell apoptosis caused by increased endoplasmic reticulum (ER) stress is an important pathogenic component of type 2 diabetes mellitus. In theory, sulfonylureas, used for the treatment of diabetes, can contribute to ER stress. We assessed changes in ER stress ..
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Insulin secretion and insulin resistance in Korean women with gestational diabetes mellitus and impaired glucose tolerance
Sae Jeong Yang, Tae Nyun Kim, Sei Hyun Baik, Tae Sun Kim, Kwan Woo Lee, Moonsuk Nam, Yong Soo Park, Jeong-Teak Woo, Young Seol Kim, Sung-Hoon Kim
Korean J Intern Med. 2013;28(3):306-313. Published online May 1, 2013
Background/AimsThe aim was to compare the insulin sensitivity and secretion index of pregnant Korean women with normal glucose tolerance (NGT), gestational impaired glucose tolerance (GIGT; only one abnormal value according to the Carpenter and Coustan criteria), and gestation..
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Rheumatology
Is the frequency of metabolic syndrome higher in South Korean women with rheumatoid arthritis than in healthy subjects?
Seung-Geun Lee, Ji-Min Kim, Sun-Hee Lee, Kye-Hyung Kim, Ji-Hye Kim, Ji-Won Yi, Woo-Jin Jung, Young-Eun Park, Seong-Hu Park, Joung-Wook Lee, Seung-Hoon Baek, Jun-Hee Lee, Geun-Tae Kim
Korean J Intern Med. 2013;28(2):206-215. Published online February 27, 2013
Background/AimsTo compare the frequency of metabolic syndrome (MetS) and magnitude of insulin resistance, measured by the homeostatic model assessment of insulin resistance (HOMA-IR), between South Korean women with rheumatoid arthritis (RA) and healthy subjects, and to evalua..
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Associations among Body Mass Index, Insulin Resistance, and Pancreatic β-Cell Function in Korean Patients with New-Onset Type 2 Diabetes
Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Korean J Intern Med. 2012;27(1):66-71. Published online February 28, 2012
Background/AimsWe investigated the associations among body mass index (BMI), insulin resistance, and β-cell function in Korean patients newly presenting with type 2 diabetes. MethodsIn total, 132 patients with new-onset type 2 diabetes mellitu..
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Insulin Resistance as a Risk Factor for Gallbladder Stone Formation in Korean Postmenopausal Women
Sang Soo Kim, Jeong Gyu Lee, Dong Wok Kim, Bo Hyun Kim, Yun Kyung Jeon, Mi Ra Kim, Jeong Eun Huh, Ji Young Mok, Seong-Jang Kim, Yong Ki Kim, In Joo Kim
Korean J Intern Med. 2011;26(3):285-293. Published online September 13, 2011
Background/AimsThe objective of this study was to determine whether insulin resistance is associated with gallbladder stone formation in Korean women based on menopausal status. MethodsThe study included 4,125 consecutive Korean subjects (30-79 ..
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The Effect of Early Insulin Therapy on Pancreatic β-Cell Function and Long-Term Glycemic Control in Newly Diagnosed Type 2 Diabetic Patients
Suk Chon, Seungjoon Oh, Sung Woon Kim, Jin-Woo Kim, Young Seol Kim, Jeong-taek Woo
Korean J Intern Med. 2010;25(3):273-281. Published online August 31, 2010
Background/AimsBased on the results of well designed clinical studies, intensive insulin therapy has been established to improve glycemic control in newly diagnosed diabetes. However, discrepancies exist between the findings of clinical trials and experiences in general pract..
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Molecular Mechanism of Insulin Resistance in Obesity and Type 2 Diabetes
Kangduk Choi, Young-Bum Kim
Korean J Intern Med. 2010;25(2):119-129. Published online June 1, 2010
Insulin resistance is a major risk factor for developing type 2 diabetes caused by the inability of insulin-target tissues to respond properly to insulin, and contributes to the morbidity of obesity. Insulin action involves a series of signaling cascades initiated by insulin binding to its recept..
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Clinical Value of Serum Uric Acid in Patients with Suspected Coronary Artery Disease
Hong Euy Lim, Seong Hwan Kim, Eung Ju Kim, Jin Won Kim, Seung Woon Rha, Hong Seog Seo, Chang Gyu Park
Korean J Intern Med. 2010;25(1):21-26. Published online February 26, 2010
Background/AimsAlthough increased serum uric acid (SUA) concentrations are commonly encountered in patients with risk factors for coronary artery disease (CAD), the clinical value of SUA has not been established. MethodsThe study group comprised..
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