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Geriatrics
Effects of aging on accompanying intermittent hypoxia in a bleomycin-induced pulmonary fibrosis mouse model
Heayon Lee, In Kyoung Kim, Jeonghyeon Im, Bae Suk Jin, Hwan Hee Kim, Sei Won Kim, Chang Dong Yeo, Sang Haak Lee
Korean J Intern Med. 2023;38(6):934-944. Published online October 5, 2023
Background/Aims: Obstructive sleep apnea (OSA) is prevalent in older patients with idiopathic pulmonary fibrosis (IPF); however, it is underrecognized. OSA is characterized by intermittent hypoxia (IH) and sleep fragmentation. In this study, we evaluated the effects of IH in an older mouse model of..
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Hemato-oncology
The prognostic impact of reduced variant burden in elderly patients with acute myeloid leukemia treated with decitabine
Mihee Kim, TaeHyung Kim, Seo-Yeon Ahn, Jun Hyung Lee, Ju Heon Park, Myung-Geun Shin, Sung-Hoon Jung, Ga-Young Song, Deok-Hwan Yang, Je-Jung Lee, Seung Hyun Choi, Mi Yeon Kim, Jae-Sook Ahn, Hyeoung-Joon Kim, Dennis Dong Hwan Kim
Korean J Intern Med. 2023;38(4):534-545. Published online June 9, 2023
Background/Aims: We evaluated the role of next-generation sequencing (NGS)-based disease monitoring for elderly patients diagnosed with acute myeloid leukemia (AML) who received decitabine therapy.
Methods: A total of 123 patients aged > 65 years with AML who received decitabine were eligible. We an..
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Geriatrics
The prognostic value of comprehensive geriatric assessment on the management of older patients with small cell lung cancer
You Jin Chun, Kwang Joon Kim, Ji Yeon Lee, Ji Won Choi, Tae Hee Kim, Hye Ryun Kim, Byoung Chul Cho, Min Hee Hong, Chang Oh Kim
Korean J Intern Med. 2023;38(2):254-263. Published online January 19, 2023
Background/Aims: The prognostic value of a comprehensive geriatric assessment (CGA) for the management of older small cell lung cancer (SCLC) patients remains to be established.
Methods: A retrospective cohort enrolled 21 SCLC patients over 65 years from March 2018 to 2019 at the Yonsei Cancer Cent..
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Hemato-oncology
Risk factors for neutropenic fever in non-Hodgkin’s lymphoma patients with primary granulocyte colony-stimulating factor prophylaxis
Yu Ri Kim, Soo-Jeong Kim, Yong Park, Sung Yong Oh, Hwan-Jung Yun, Yeung-Chul Mun, Jin Seok Kim; the Korean Society of Hematology Lymphoma Working Party
Korean J Intern Med. 2021;36(5):1181-1189. Published online July 16, 2021
Background/Aims: Febrile neutropenia (FN) interferes with the proper chemotherapy dose density or intensity in non-Hodgkin’s lymphoma (NHL) patients. Chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) ± rituximab has an intermediate FN risk. Prophylactic granulocy..
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Clinical characteristics and survival of colorectal cancer patients in Korea stratified by age
Sun Kyung Baek, Ji Sung Lee, In Gyu Hwang, Jong Gwang Kim, Tae Won Kim, Seung Kook Sohn, Mi Yeon Kang, Sang-Cheol Lee
Korean J Intern Med. 2021;36(4):985-991. Published online April 6, 2021
Background/Aims: This nationwide study was undertaken to determine differences in clinicopathologic characteristics and survival of patients with colorectal cancer (CRC) according to age using big data from the Korean National Health Insurance Service (NHIS).
Methods: The NHIS data including qualit..
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Geriatrics
Validation of the Korean Frailty Index in community-dwelling older adults in a nationwide Korean Frailty and Aging Cohort study
Hee-Won Jung, Sunyoung Kim, Chang Won Won
Korean J Intern Med. 2021;36(2):456-466. Published online April 17, 2020
Background/Aims: We aimed to assess validity of the Korean Frailty Index (KFI) and the modified KFI (mKFI) in nationwide Korean population as screening measures for frailty status in older adults.
Methods: Analysis was performed in the records of baseline assessments of 2,886 participants in the Ko..
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Allergy
Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population
Byung-Keun Kim, Woo-Jung Song, Bomi Seo, Ju-Young Kim, Sae-Hoon Kim, Hak C. Jang, Ki-Woong Kim, Yoon-Seok Chang
Korean J Intern Med. 2021;36(2):447-455. Published online October 13, 2020
Background/Aims: Recent evidence suggests an association between allergic sensitization and metabolic markers. However, this association has rarely been examined in the elderly. Retinol-binding protein-4 (RBP-4) is a recently identified adipokine that acts on the muscle and liver affecting insulin s..
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Chronic cough, not asthma, is associated with depression in the elderly: a community-based population analysis in South Korea
Kyoung-Hee Sohn, Woo-Jung Song, Sae-Hoon Kim, Hak-Chul Jang, Ki Woong Kim, Yoon-Seok Chang
Korean J Intern Med. 2019;34(6):1363-1371. Published online October 16, 2019
Background/Aims: Depression and allergic diseases, including asthma, are frequently reported as comorbid conditions. However, their associations have been rarely examined in community-based elderly populations.
Methods: The analyses were performed using the baseline data set of the Korean Longitudi..
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Etc.
The Korean version of the FRAIL scale: clinical feasibility and validity of assessing the frailty status of Korean elderly
Hee-Won Jung, Hyun-Jung Yoo, Si-Young Park, Sun-Wook Kim, Jung-Yeon Choi, Sol-Ji Yoon, Cheol-Ho Kim, Kwang-il Kim
Korean J Intern Med. 2016;31(3):594-600. Published online December 23, 2015
Background/Aims: The fatigue, resistance, ambulation, illnesses, and loss of weight (FRAIL) scale is a screening tool for frailty status using a simple 5-item questionnaire. The aim of this study was to evaluate the clinical feasibility and validity of the Korean version of the FRAIL (K-FRAIL) scale..
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Infectious diseases
A comparison of the clinical characteristics of elderly and non-elderly women with community-onset, non-obstructive acute pyelonephritis
U-Im Chang, Hyung Wook Kim, Yong-sun Noh, Seong-Heon Wie
Korean J Intern Med. 2015;30(3):372-383. Published online April 29, 2015
Background/Aims: Acute pyelonephritis (APN) is the most common cause of community-onset bacteremia in hospitalized elderly patients. The objectives of this study were to investigate the differences in the clinical and microbiological data of hospitalized elderly and non-elderly women with community-..
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