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Pulmonology
Relationship between metformin use and mortality in tuberculosis patients with diabetes: a nationwide cohort study
Eunki Chung, Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Heejin Kim, Heesun Kim, Hongjo Choi, Young Ae Kang
Korean J Intern Med. 2024;39(2):306-317. Published online February 6, 2024
Background/Aims: To determine whether metformin, which is considered a host-directed therapy for tuberculosis (TB), is effective in improving the prognosis of patients with TB and diabetes mellitus (DM), who have higher mortality than those without DM.
Methods: This cohort study included patients w..
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Cardiology
Time to presentation and mortality outcomes among patients with diabetes and acute myocardial infarction
Min-A Shin, Seok Oh, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong
Korean J Intern Med. 2024;39(1):110-122. Published online December 11, 2023
Background/Aims: Due to limited real-world evidence on the association between time to presentation (T2P) and outcomes following acute myocardial infarction and diabetes (AMI-DM), we investigated the characteristics of patients with AMI-DM and their outcomes based on their T2P.
Methods: 4,455 patie..
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Endocrinology-metabolism
Diabetes screening in South Korea: a new estimate of the number needed to screen to detect diabetes
Kyoung Hwa Ha, Kyung Ae Lee, Kyung-Do Han, Min Kyong Moon, Dae Jung Kim
Korean J Intern Med. 2023;38(1):93-100. Published online November 24, 2022
Background/Aims: The Korean Diabetes Association (KDA) guidelines recommend adults aged ≥ 40 years and adults aged ≥ 30 years with diabetes risk factors for diabetes screening. This study aimed to determine the age threshold for diabetes screening in Korean adults.
Methods: This study was based o..
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Comorbidities associated with high-risk obstructive sleep apnea based on the STOP-BANG questionnaire: a nationwide population-based study
Gene Huh, Kyoung do Han, Yong-Moon Park, Chan-Soon Park, Kyu-na Lee, Eun Young Lee, Jung-Hae Cho
Korean J Intern Med. 2023;38(1):80-92. Published online November 10, 2022
Background/Aims: We investigated the prevalence, associated factors, and comorbidities of high-risk obstructive sleep apnea (OSA) as determined by the STOP-BANG questionnaire in a Korean adult population.
Methods: Data were obtained from 7,650 adults (aged ≥ 40 years) who participated in the Korea ..
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Gastroenterology
Long-term effect of the eradication of Helicobacter pylori on the hemoglobin A1c in type 2 diabetes or prediabetes patients
Won Seok Kim, Yonghoon Choi, Nayoung Kim, Seon Hee Lim, Gitark Noh, Ki Wook Kim, Jaehyung Park, Hyeongho Jo, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
Korean J Intern Med. 2022;37(3):579-590. Published online January 7, 2022
Background/Aims: The long-term effect of Helicobacter pylori eradication on the metabolic syndrome or diabetes are unclear. The aim of this study was to evaluate the effect of H. pylori eradication on glycemic control in type 2 diabetes mellitus (T2DM) or prediabetes mellitus (preDM).
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Cardiology
Sex differences in long-term clinical outcomes of acute myocardial infarction according to the presence of diabetes mellitus
Yu Ri Kim, Myung Ho Jeong, Youngkeun Ahn, Ju Han Kim, Young Joon Hong, Min Chul Kim, Kyung Hoon Cho, Xiong Yi Han; other KAMIR-NIH Registry Investigators
Korean J Intern Med. 2021;36(Suppl 1):S99-S113. Published online January 12, 2021
Background/Aims: This study compared long-term clinical outcomes between male and female acute myocardial infarction (AMI) patients with and without diabetes mellitus (DM).
Methods: From November 2011 to December 2015, 13,104 patients with AMI were enrolled in the Korea Acute Myocardial Infarction ..
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Long-term effects of the mean hemoglobin A1c levels after percutaneous coronary intervention in patients with diabetes
Jaekyung Bae, Ji-Hyung Yoon, Jung-Hee Lee, Jong-Ho Nam, Chan-Hee Lee, Jang-Won Son, Ung Kim, Jong-Seon Park, Dong-Gu Shin
Korean J Intern Med. 2021;36(6):1365-1376. Published online October 14, 2021
Background/Aims: The clinical benefit of strict blood glucose-lowering therapy for patients with coronary artery disease (CAD) is still debated. We aimed to evaluate the long-term outcomes of patients with diabetes who underwent percutaneous coronary intervention (PCI), according to the mean hemoglo..
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Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need
Ye Seul Yang, Kyungdo Han, Tae Seo Sohn, Nam Hoon Kim
Korean J Intern Med. 2021;36(5):1049-1058. Published online September 1, 2021
The prevalence of young-onset (diagnosis at age < 40 years) type 2 diabetes mellitus (T2DM) is increasing globally. Young-onset T2DM has a common pathophysiology of glucose dysregulation as in late-onset T2DM. However, it presents a greater association with obesity and a more rapid decline in β-ce..
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Endocrinology-metabolism
Impact of urgently initiated tele-prescription due to COVID-19 on glycemic control in patients with type 2 diabetes
Sung-Don Park, Na-young Kim, Jae-Han Jeon, Jung-Guk Kim, In-Kyu Lee, Keun-Gyu Park, Yeon-Kyung Choi
Korean J Intern Med. 2021;36(4):942-948. Published online June 7, 2021
Background/Aims: Coronavirus disease 2019 (COVID-19) is a global pandemic that had affected more than 13,000 people in South Korea by July 2020. To prevent spread of COVID-19, tele-prescription was permitted temporarily. This study investigated the impact of tele-prescription on glycemic control in ..
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Weight change and microvascular outcomes in patients with new-onset diabetes: a nationwide cohort study
Eun Sil Koh, Kyung Do Han, Mee Kyoung Kim, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
Korean J Intern Med. 2021;36(4):932-941. Published online May 13, 2021
Background/Aims: Because weight control is important in treatment of type 2 diabetes, it is essential to understand the associations between weight change and the risk of microvascular complications among patients with type 2 diabetes. We examined whether weight changes early after new-onset diabete..
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Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study
Yi-Suk Kim, Yong-Moon Park, Kyung-Do Han, Jae-Seung Yun, Yu-Bae Ahn, Seung-Hyun Ko
Korean J Intern Med. 2021;36(3):647-658. Published online July 7, 2020
Background/Aims: Although people with diabetes have been shown to have higher mortality than people without diabetes, there is a lack of data on the association between fasting plasma glucose (FPG) levels and cause-specific mortality rates in the general population.
Methods: A total of 326,547 Kore..
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Gastroenterology
Effect of Helicobacter pylori treatment on the long-term mortality in patients with type 2 diabetes
Young-Il Kim, Young Ae Kim, Hak Jin Kim, Su-Hyun Kim, Yul Hwangbo, Jae Gyu Kim, Jae J. Kim, Il Ju Choi
Korean J Intern Med. 2021;36(3):584-595. Published online November 25, 2020
Background/Aims: Meta-analyses of randomized trials reported a non-significant increase in overall mortality risk after Helicobacter pylori eradication. In this study, we investigated whether H. pylori treatment is associated with increased risk of overall mortality in patients with ty..
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Endocrinology-metabolism
Impaired fasting glucose levels in overweight or obese subjects for screening of type 2 diabetes in Korea
Jin-Hee Lee, Suk Chon, Seon-Ah Cha, Sun-Young Lim, Kook-Rye Kim, Jae-Seung Yun, Sang Youl Rhee, Kun-Ho Yoon, Yu-Bae Ahn, Jeong-Taek Woo, Seung-Hyun Ko; Korean Diabetes Prevention Study Investigators
Korean J Intern Med. 2021;36(2):382-391. Published online March 5, 2020
Background/Aims: We examined the concordance rate among fasting plasma glucose (FPG), 2-hour post-challenge glucose (2hr PG), and hemoglobin A1c (HbA1c) in the diagnosis of diabetes in a population with a high-risk for type 2 diabetes mellitus (T2DM) in Korea.
Methods: Among the participants from th..
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Severe hypoglycemia as a preventable risk factor for cardiovascular disease in patients with type 2 diabetes mellitus
Soo-Yeon Choi, Seung-Hyun Ko
Korean J Intern Med. 2021;36(2):263-270. Published online January 8, 2021
Glucose-lowering medication and lifestyle modification are essential for optimal glycemic control in patients with type 2 diabetes mellitus (T2DM). However, glucose-lowering agents, particularly insulin and insulin secretagogues, may cause hypoglycemia, which has multiple negative effects on the car..
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Acute pancreatitis and diabetes mellitus: a review
Allyson Richardson, Walter G. Park
Korean J Intern Med. 2021;36(1):15-24. Published online December 4, 2020
Diabetes following acute pancreatitis (AP) is becoming increasingly recognized. It is unclear what subtype of diabetes mellitus (DM) occurs; however, type 3c diabetes mellitus (T3cDM) is gaining increasing recognition. T3cDM has differing pathophysiology than other subtypes of DM and therefore diffe..
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Nephrology
The therapeutic efficacy of water-soluble coenzyme Q10 in an experimental model of tacrolimus-induced diabetes mellitus
Yi Quan, Kang Luo, Sheng Cui, Sun Woo Lim, Yoo Jin Shin, Eun Jeong Ko, Ju Hwan Kim, Sang J. Chung, Soo Kyung Bae, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2020;35(6):1443-1456. Published online April 14, 2020
Background/Aims: Coenzyme Q10 (CoQ10) has antioxidant effects and is commercially available and marketed extensively. However, due to its low bioavailability, its effects are still controversial. We developed a water-soluble CoQ10-based micelle formulation (CoQ10-W) ..
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Endocrinology-metabolism
Optimal body mass index for minimizing the risk for osteoporosis and type 2 diabetes
Ji Hyun Lee, Jung Hee Kim, A Ram Hong, Sang Wan Kim, Chan Soo Shin
Korean J Intern Med. 2020;35(6):1432-1442. Published online October 30, 2019
Background/Aims: Body mass index (BMI) is positively associated with bone mineral density and type 2 diabetes. We investigated an optimal BMI range for osteoporosis and type 2 diabetes.
Methods: This cross-sectional study used data from the Korea National Health and Nutrition Examination Survey (KN..
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Clinical spectrum and diagnosis of diabetic neuropathies
Jeeyoung Oh
Korean J Intern Med. 2020;35(5):1059-1069. Published online August 28, 2020
Neuropathy is the most prevalent microvascular complication of diabetes mellitus; it encompasses distal symmetric polyneuropathy, autonomic neuropathy, radiculoplexus neuropathy, mononeuropathy, and treatment-induced neuropathy. The prevalence rate of diabetic neuropathy in Korea was reported to be ..
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Endocrinology-metabolism
Higher glucagon-to-insulin ratio is associated with elevated glycated hemoglobin levels in type 2 diabetes patients
Minyoung Lee, Minkyung Kim, Jong Suk Park, Sangbae Lee, Jihong You, Chul Woo Ahn, Kyung Rae Kim, Shinae Kang
Korean J Intern Med. 2019;34(5):1068-1077. Published online September 8, 2017
Background/Aims: The importance of α-cell dysfunction in the pathogenesis of type 2 diabetes has re-emerged recently. However, data on whether relative glucagon excess is present in clinical settings are scarce. We aimed to investigate associations between glucagon-to-insulin ratio and various meta..
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Nephrology
The effects of addition of coenzyme Q10 to metformin on sirolimus-induced diabetes mellitus
In O Sun, Long Jin, Jian Jin, Sun Woo Lim, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2019;34(2):365-374. Published online December 13, 2017
Background/Aims: This study was performed to determine whether adding coenzyme Q10 (CoQ10) to metformin (MET) has a beneficial effect as a treatment for sirolimus (SRL)-induced diabetes mellitus (DM).
Methods: DM was induced in rats by daily treatment with SRL (0.3 mg/kg, subc..
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